Functional seizures, otherwise known as psychogenic nonepileptic seizures (PNES), can appear behaviorally similar to epileptic seizures, but their treatment is fundamentally different. However, the average delay to diagnosis of functional seizures was 8.4 years (median 3 years), during which patients are treated ineffectively for epilepsy. I'll review the computer-aided diagnostic tools that we've developed for the early identification of patients with functional seizures using clinical history, EEG, and MRI. I'll also discuss how these tools may interact with clinical wisdom to shorten delays to diagnosis because we think earlier diagnosis also leads to more effective treatment. I'll also make a brief note about how we're working to validate Time-to-Event designed clinical trials for seizures, which aim to improve trial safety, recruitment, and cost by identifying non-responders earlier.
Neurology/Neuroscience Research Seminar
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