Friday, December 8, 2023

Neurology/Neuroscience Research Seminar

12:00 PM to 1:00 PM

Room 5515 in BSRB 

CME credit is available, click here

Attendance must be registered within 6 months of attendance to be awarded credit.

Recorded archives of live activities are considered enduring materials.

Viewing of a recorded session is for reference only, no CME credit can be claimed.

Join us

Several subtypes of inherited peripheral neuropathy (Charcot-Marie-Tooth disease) are caused by dominant mutations in tRNA synthetase genes, encoding the housekeeping enzymes that charge amino acids onto their cognate tRNAs.  Recent work exploring the disease mechanism identified the activation of the integrated stress response (ISR) through the sensor kinase GCN2 as a key contributor to the pathophysiology of at least two tRNA synthetase-associated forms of CMT modeled in mice.  These studies have not only improved our understanding of the disease process and progression, they also provide potential therapeutic strategies that we are testing in preclinincal studies.

“Disease Mechanisms and Therapeutic Strategies for tRNA Synthetase-Associated Peripheral Neuropathies”

Robert Burgess, Ph.D.

Professor, Jackson Laboratory