Comprehensive Epilepsy Program

The epilepsy faculty participate in diverse research efforts ranging from individual clinical projects to nationally-funded multicenter clinical trials and basic science studies.  Multiple clinical and basic science research laboratories are run by our faculty, who receive funding from NIH (currently 4 R01, 1 U54 and multiple K awards), private foundations and industry. We were part of a prior NIH Epilepsy Centers Without Walls (CWOW) U grant to study SUDEP (Sudden Unexpected Death in Epilepsy), and we currently lead a second NIH Epilepsy CWOW on Functional Genetics in Epilepsy. Active research collaborations with other departments or programs include interdisciplinary studies with Biological Chemistry, Bioengineering, Human Genetics, the Michigan Neuroscience Institute, Molecular and Integrative Physiology, Neuroradiology (including functional and structural MRI, PET and SPECT studies), Neurosurgery, Pharmacology, Physics, Psychiatry and Psychology. Ongoing research investigations include:

  • Experimental anti-seizure drug trials
  • Basic science studies of experimental temporal lobe epilepsy
  • Mouse, zebrafish and human pluripotent stem cell studies of genetic epilepsies
  • Rodent in vivo genome editing models of focal cortical dysplasia
  • The effects of sleep apnea treatment on epilepsy
  • Vagal nerve stimulation in children and adults
  • Bioengineering applications to epilepsy research, including studies of seizure prediction and biomarkers of epileptogenesis, such as automated analysis of high-frequency oscillations
  • Coping strategies and treatment of psychogenic nonepileptic seizures
  • Epilepsy health services and outcomes research
  • Optimization of EEG in critical care
  • Psychosocial and disability determinants in epilepsy
  • SUDEP mechanisms and biomarkers