Aditya S. Pandey, M.D. achieved his Bachelors of Science in Biological and Engineering Sciences from the Washington University in St. Louis and Doctorate of Medicine from Case Western Reserve University School of Medicine. He then gained training in neurological surgery with sub-specialty training in microsurgical and endovascular treatment of cerebrovascular disorders under the guidance of Dr. Robert Rosenwasser at Thomas Jefferson University Hospital. Dr. Pandey specializes in treating individuals who have blood vessel related diseases of the brain and spinal cord (e.g., aneurysms, AVM, stroke, fistulas, cavernomas, bleeding within the brain, etc.) as well as practicing general neurosurgery (spinal disorders, brain tumors, and traumatic brain injury). Dr. Pandey is able to perform the latest techniques to treat stroke utilizing suction-stent thrombectomy techniques as well as treating the most complex of aneurysms utilizing flow diversion technology. He is one of two neurosurgeons in the Ann Arbor region who are trained to perform both open surgeries and endovascular procedures when treating patients with brain blood vessel related diseases.
His research interests include: development of ultrasound technology for incisionless treatment of neurosurgical patient populations, understanding the role of CSF toxins in the development of post hemorrhagic hydrocephalus, and understanding opportunities of improvement of clinical outcomes of stroke patients through collaboration and large database analysis. His collaborative research and innovation have culminated in numerous IP opportunities, more than 150 peer reviewed publications, and grant support from the NIH, American Heart Association, American Hydrocephalus Association, Joint Institute, the Joe Niekro Aneurysm Foundation, and the Focused Ultrasound Foundation.
- Dr. Pandey Co-leads efforts with Dr. Xu, from Biomedical Engineering, in developing ultrasound based histotripsy technology for incisionless treatment of patients with hemorrhagic stroke and brain tumors. This therapeutic intervention allows for the treatment of lesions in the brain without having to remove the skull or even make an incision. His efforts of advancing the histotripsy technology to the bedside is funded by the NIH.
- Dr. Pandey collaborates with Dr. Shih in the development of a smart drill which automatically stops once penetrating the inner cortex as well as the design of a microcatheter which can measure bioimpedance of intravascular clot and identify RBC rich vs. RBC poor clots. His collaboration with Dr. Pipe has led to the development of a hypothermia tool which is being designed to precisely and selectively cool the brain while maintaining normal core body temperatures. All of these devices have led to filing of provisional patent applications.
- Dr. Pandey in coordination with Drs. Xi and Keep are evaluating the role of peroxiredoxin-2 and carbonic anhydrase in the development of post hemorrhagic hydrocephalus towards a goal of medical management of hydrocephalus. Brain bleeding leads to fluid accumulation within the brain which then requires treatment with surgical intervention. To date, a medical therapy to treat or prevent hydrocephalus does not exist. Utilizing cerebrospinal fluid from brain bleed patients, he aims to identify the role of different toxins in hydrocephalus formation as well as the role of specific antidotes to those toxins in preventing hydrocephalus. Dr. Pandey has received the Innovator award through the American Hydrocephalus Association for the study of hydrocephalus.
- Dr. Pandey has worked with a multidisciplinary group at Michigan Medicine in evaluating large databases and reporting that volume outcome relationships exist in the management of ruptured aneurysms and that changes in stroke care are leading to lower mortality and improved clinical outcomes. He is currently working with colleagues to understand whether the development of stroke centers is leading to dilution of hemorrhagic stroke volume and associated changes in clinical outcome. He has also organized a volunteer group of cerebrovascular specialists across the state with the aim of data sharing and identification of opportunities of improving cerebrovascular care. These efforts are currently under consideration for a statewide clinical quality initiative.
- Dr. Pandey has participated in numerous clinical trials including being the lead PI for the SPAR trial (evaluating the role of seizure medication in aneurysm treatment) and the currently initiated DISH trial (evaluating the role of deferoxamine in the management of ruptured aneurysm patients). DISH trial will be the first trial to evaluate the role of iron chelation in management of SAH patients. This trial is funded through the Joint Institute and will also involve patients from Peking University.
- Dr. Pandey has led efforts to develop philanthropic support of hemorrhagic stroke research through the Brain Bleed Initiative (BBI). Funds available through the BBI will allow for completion of clinical translation projects with the aim of improving clinical care of all brain bleed patients.
Aneurysms, AVM's, extracranial and intracranial stenosis, neurovascular disorders, cervical spinal pathology, brain tumors, and stroke.
Case Western Reserve University School of Medicine, 2001
Neurological Surgery, Thomas Jefferson University Hospital, 2007
Vascular/Endovascular Surgery & Interventional Radiology, Thomas Jefferson University Hospital, 2008
- Johns Hopkins University
MISTIE III Health and Human Services
Goal: To evaluate the role of intra-clot delivery of tPA via image guided placement of a ventriculostomy catheter in improving ICH evacuation and related improvement in cerebral edema and clinical outcome.
- Vanderbilt University Medical Center
Framing Eighteen Coils in Cerebral Aneurysms Trial (FEAT)
Goal: To compare angiographic outcomes in patients receiving 0.014-0.0155” platinum framing and filling coils followed by further aneurysm filling and finishing with less than 0.014” bare platinum coils (as deemed appropriate by the treating physician), versus those treated solely with coils less than 0.014”. We hypothesize that angiographic occlusion at follow-up imaging will be more frequent in patients receiving 0.014-0.0155” platinum coils during embolization compared to those receiving smaller-diameter coils.
Role: Subcontract PI
- University of Louisville Research Foundation
Aneurysmal Subarachnoid Hemorrhage Trial Randomizing Heparin (ASTROH)
Goal: The role of intravenous heparin administration in preventing delayed cerebral ischemia and improving clinical outcome.
Role: Subcontract PI
- NIH R21-NS099684 (Chaudhary, PI)
Brain Iron Quantification Based on MRI in Intracerebral Hemorrhage
Goal: Quantify cerebral iron deposition in patients harboring ICH.
- University of Texas Health Science Center at Houston
The Intra-Arterial Vasospasm Trial-A Multi-Center Study
Goal: To treat and determine the best treatment regimen to treat cerebral vasospasm (blood vessel constriction) refractory to medical management following subarachnoid hemorrhage (bleeding in the area between the brain and the thin tissues that cover the brain) due to brain aneurysm rupture.
Role: Subcontract PI
- Cleveland Clinic Lerner College of Medicine (Vince, PI)
Vortex Catheter Technology for Mechanical Thrombectomy
Goal: Develop a new low-profile device for mechanical thrombectomy in stroke.
- NIH R01 NS108042 01A1 (Pandey, PI)
Novel Ultrasonic Technique for the Treatment of Hemorrhagic Stroke
Goal: The aim of this project is to examine if ultrasonic technique can enhance hematoma removal.
- NIH 1R21NS104663 (Chaudhary, Pandey, Co-PIs)
Phenomenon of Ultra-Early Intracranial Hemorrhage in Humans on MRI
Goal: In the ultra-early erythrolysis to evaluate the phenomenon of ultraearly erythrolysis, demonstrated in the animal model, in human subjects with ICH.