Aanda Alexandra Calinescu

Alexandra Calinescu, M.D., Ph.D.

Research Assistant Professor, Neurosurgery

Honors & Awards

  • Kellogg Eye Center Research Award for innovative research toward the discovery of new treatments for blinding diseases, 2004.


Medical School

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 1994

Graduate School

Ph.D. - Neuroscience, University of Michigan, 2008


  • R21 - Engineering stem cells as diagnostic and therapeutic agents for glioblastoma – (R21 NIH/NINDS 2018-2020).
  • Fellowship Grant - Tissue Engineering at Michigan, for research to advance the field of regenerative biology, 2004-2006.

Published Articles or Reviews

  1. Calinescu AA, Yadav VN, Carballo E, Kadiyala P, Tran D, Zamler DB, Doherty R, Srikanth M, Lowenstein PR, Castro MG. Survival and Proliferation of Neural Progenitor-Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism. Clin Cancer Res. 2017 Mar 1;23(5):1250-1262. doi: 10.1158/1078-0432.CCR-15-2888. Epub 2016 Aug 19.PMID:01727542769
  2. Castro MG, Candolfi M, Wilson TJ, Calinescu A, Paran C, Kamran N, Koschmann C, Moreno-Ayala MA, Assi H, Lowenstein PR. Adenoviral vector-mediated gene therapy for gliomas: Coming of age. Expert Opin Biol Ther. 2014 Apr 29.
  3. Luo J, Uribe RA, Hayton S, Calinescu AA, Gross JM, Hitchcock PF. Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina. Neural Dev. 2012 Oct 30; 7(1): 33.
  4. Calinescu AA, Liu T, Wang M, Borjigin J. Transsynaptic activity-dependent regulation of axon branching and neurotropin expression in vivo. J Neuroscience. 2011, 31(36): 12708-15.
  5. Borjigin J, Zhang LS, Calinescu AA. Circadian regulation of pineal gland rhythmicity. Mol Cell Endocrinol. 2012 Feb 5; 349(1): 13-9.
  6. Cui TX, Lin G, Lapensee CR, Calinescu AA, Rathore M, Streeter C, Piwien-Pilipuk G, Lanning N, Jin H, Carter-Su C, Qin ZS, Schwartz J. C/EBPb mediates growth hormone-regulated expression of multiple target genes. Mol Endocrinol. 2011 Apr; 25(4): 681-93.
  7. Calinescu AA, Raymond PA, Hitchcock PF. Midkine expression is regulated by circadian clock in the retina of zebrafish. Vis Neurosco. 2009 Nov; 26(5-6): 495-501.
  8. Calinescu AA, Vihtelic TS, Hyde DR, Hitchcock PF. Cellular expression of midkine-a and midkine-b during retinal development and photoreceptor regeneration in zebrafish. J Comp Neurol. 2009 May 1; 514(1): 1-10.
  9. Craig SE, Calinescu AA, Hitchcock PF. Identification of the molecular signatures integral to regenerating photoreceptors in the retina of zebrafish. J Ocul Biol Dis Infor. 2008 Dec; 1(2-4): 73-84.
  10. Ceseña TI, Cui TX, Piwien-Pilipuk G, Kaplani J, Calinescu AA, Huo JS, Iñiguez-Liuhí JA, Kwok R, Schwartz J. Multiple machanisms of growth hormone-regulated gene expression. Mol Genet Metab. 2007 Feb; 90(2): 126-33.
  11. Hitchcock P, Ochocinska M, Sieh A, Otteson D. Persistent and injury-induced neurogenesis in the vertebrate retina. Prog Retin Eye Res. 2004 Mar; 23(2): 183-94.