Areas of Interest
Dr. Keep's primary interests focus on the blood-brain and blood-CSF barriers (the tissue interfaces between the brain and blood) and on stroke. In particular, he has interest in how pathological conditions affect the blood-brain barriers, how the barriers can be protected by techniques such as preconditioning, the normal physiological functions of the barrier tissues and drug transport between blood and brain. These processes are examined in vivo (using rodent models of disease) and using in vitro models of the blood-brain and blood-CSF barriers. In relation to stroke, the Keep Lab investigates the mechanisms of brain injury that follows hemorrhagic and ischemic stroke. Using rodent models of intracerebral hemorrhage, they focus on the roles of thrombin, iron, complement and inflammation in inducing brain injury. In ischemic stroke, they focus on the roles of thrombin, endothelial injury and inflammation in brain injury. Lastly, they examine the effects of novel preconditioning stimuli on both hemorrhagic and ischemic brain injury.
- 2013-2016 - CD47 and hematoma clearance in intracerebral hemorrhage; Sponsor: NIH
- 2013-2018 - Development of Mixed Function Opiod Peptides and Peptidomimetics; Sponsor: NIH
- 2013-2016 - Novel Probes for Studying Treatment of CNS-based Lysosomal Storage Diseases; Sponsor: NIH
- 2012-2014 - Blood-Brain Barrier in Neuroinflammation; Sponsor: NIH
- 2012-2017 - Mechanisms of early brain injury after subarachnoid hemorrhage; Sponsor: NIH
- 2012-2017 - Mechanisms of Brain Injury after Intravantricular Hemorrhage; Sponsor: NIH
- 2011-2013 - The Notch signaling pathway in glioblastoma; Sponsor: NIH
- 2011-2013 - The mechanism of blood brain barrier impairment in cerebral cavernous malformation 3; Sponsor: NIH
- 2010-2015 - Novel Therapeutics for Neotropic Alphaviruses; Sponsor: NIH
- 2009-2014 - Endogenous and Exogenous Protection of the BBB in Stroke; Sponsor: NIH
- 2008-2014 - Estrogen Effects on Complement-Mediated Brain Injury in Intracerebral Hemorrhage; Sponsor: NIH
- 2008-2013 - Mechanism of Thrombin-Induced Tolerance to Brain Injury; Sponsor: NIH
- 2001-2013 - Thrombin in Brain Recovery after Intracerebral Hemorrhage; Sponsor: American Heart Association, Inc.