Dr. Toshiro Hara received his B.S. from Osaka University, Japan, and his Ph.D. in Life Sciences from the University of Tokyo for studies on the metabolic regulation of macrophages with Dr. Motoharu Seiki at the Institute of Medical Science, the University of Tokyo. He then joined the laboratory of Dr. Inder Verma, later of Dr. Tony Hunter, at the Salk Institute for Biological Studies, La Jolla.
He initiated his postdoctoral work on intratumoral heterogeneity in glioblastoma by combining a mouse model of glioma with lineage tracing approaches, including lentiviral barcoding for single-cell RNA-seq in collaboration with Dr. Aviv Regev at the Broad Institute of MIT and Harvard. In 2019, he then, as a research fellow, joined Dr. Mario Suva’s laboratory in the Department of Pathology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), and the Broad Institute. His postdoctoral studies delineated cellular states and plasticity in human glioblastoma and uncovered their molecular and cellular determinants.
The research in his laboratory is directed toward understanding the intratumoral heterogeneity and the mechanisms of cellular communication within this intratumoral microenvironment as it relates to brain tumors.