Patrice E. Fort, PhD, MS
Inflammation is increasingly recognized as a major player in the pathophysiological mechanisms of diabetic retinopathy. Through our discovery approaches performed on ocular tissues from human donors with and without diabetes and/or retinopathy, several inflammatory regulators have been identified and are currently under investigation.
Additionally, alpha-crystallins have been associated with inflammation in multiple sclerosis and other neuro-inflammatory associated diseases, but the potential interaction in diabetic retinopathy has not been explored. We are exploring the role of alpha-crystallins in the regulation of the retinal inflammatory response using cell culture methods as well as animal models of neuro-infllammatory diseases.