Thomas Wubben, MD, PhD

Thomas Wubben, MD, PhD

Assistant Professor, Ophthalmology and Visual Sciences
Academic Office: 734-936-9547

Areas of Interest

Research Summary

Dr. Wubben’s research focuses on the intersection of retinal metabolism and vitreoretinal disease. Understanding the metabolic pathways that support retinal cell function and survival and how these pathways are rewired in certain disease states is expected to provide a framework for developing novel therapeutic paradigms to prevent vision loss in those afflicted with retinal disease.

The laboratory utilizes advanced techniques in molecular biology and mass spectrometry-based metabolomics to unravel the metabolic pathways crucial to the function and survival of photoreceptors and the retinal pigment epithelium (RPE) in multiple experimental systems. These systems include mouse models of retinal dystrophies and retinal detachment, rabbit models of proliferative vitreoretinopathy (PVR), and RPE cell culture models of macular degeneration and PVR. The insight obtained from such studies will be employed to design metabolism-based therapies. Dr. Wubben collaborates with world-renowned vision scientists as well as experts in other disciplines to expand research efforts and our comprehensive understanding of cellular metabolism.

Dr. Wubben’s work has been funded by a variety of internal and external grants and has resulted in numerous impactful publications. For more information, please contact Dr. Wubben.

Clinical Interests

Subspecialty: Retina

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Honors & Awards

2018

  • Award, Ronald G. Michels Fellowship Foundation
  • Award, Reprogramming Photoreceptor Metabolism by Altering PKM2 Function as a Novel Neuroprotective Strategy, VitreoRetinal Surgery Foundation
  • Invited Speaker, RPB/AUPO Resident and Fellow Research Forum, Association of University Professors in Ophthalmology (AUPO)
    Lecture: "Photoreceptor Metabolic Reprogramming Inhibits Apoptosis in Acute Stress While Causing Chronic Degeneration"

2017

  • Heed Fellowship, Heed Ophthalmic Foundation 

Credentials

  • MD - University of Illinois at Chicago
  • PhD - University of Illinois at Chicago
  • Residency - Kellogg Eye Center, University of Michigan
  • Fellowship, Surgical Retina, Uveitis, and Ocular Oncology, Kellogg Eye Center, University of Michigan

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