Dr. Victor Elner

Victor M. Elner, MD, PhD

Ravitz Foundation Professor of Ophthalmology and Visual Sciences
Professor, Department of Pathology
Academic Office: 734-764-4182

Areas of Interest

Research Summary

Mechanisms of retinal, orbital, and corneal inflammation and immunity; orbital diseases and tumors; lid and orbital anatomy

Inflammation plays an important role in many eye diseases that are leading causes of blindness in the United States. Ocular infections, injury, uveitis, corneal graft rejection, proliferative vitreoretinopathy, retinal detachment, macular degeneration, and diabetic retinopathy all have in common the mobilization of white blood cells into diseased eye tissues and the production of inflammatory mediators. To investigate how inflammation is mediated in the eye, Drs. Susan and Victor Elner have been studying pro-inflammatory mediators (cytokines) and white blood cell adhesion molecules that are expressed by various types of ocular cells. They have shown that retinal cells may produce interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1), cytokines that attract and activate white blood cells during inflammation. One of these cytokines, IL-8, also has the ability to induce abnormal new blood vessel growth and cause retinal cells to produce peroxides and superoxides, which may further damage diseased tissue. The Elners have identified another cytokine, IP-10, in ocular cells and disease. In contrast to IL-8, IP-10 can prevent new blood vessel growth, particularly blood vessel growth induced by IL-8. They are currently studying the role of IL-8 and IP-10 in diseases such as diabetes in which new blood growth may lead to vision loss. In addition, cell-cell adhesion between white blood cells and retinal cells may produce very high levels of IL-8 and MCP-1, exacerbating this inflammatory process.

In recent experiments the Elners have shown that another cytokine, interleukin-10, is able to inhibit the increase of IL-8 and MCP-1 levels, and lessen their destructive effects in corneas infected with Herpes Simplex Virus 1. Their investigation of these cellular mechanisms will help direct the development of therapeutic interventions aimed at the inflammatory cell component of many common and serious eye diseases.

Clinical Interests

Evaluation and treatment of eyelid and orbital tumors, thyroid (Graves') eye disease, eyelid and brow ptosis, eyelid malpositions, lacrimal system abnormalities; comprehensive ophthalmic pathology

Subspecialties: Oculoplastics; Ophthalmic Pathology

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Honors & Awards

2018

  • Inaugural Dortzbach Lecture, North American Society of Academic Orbital Surgeons (NASAOS)

2017

  • Castle Connolly Top Doctor

Credentials

  • Medical School - University of Chicago, 1979
  • Residencies
    • Ophthalmology, University of Chicago, 1982
    • Pathology, University of Chicago, 1985
  • Fellowships
    • Ophthalmic Pathology, Armed Forces Institute of Pathology, 1985
    • Ophthalmic Plastic and Reconstructive Surgery, University of Wisconsin, 1987

Published Articles or Reviews

Web Sites