Research Investigator
Orthopaedic Surgery
Orthopaedic Surgery
109 Zina Pitcher
Ann Arbor, MI 48109
[email protected]
109 Zina Pitcher
Ann Arbor, MI 48109
Available to mentor
Adam C Abraham
Research Investigator
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Postdoctoral Research ScientistColumbia University Medical Center, Orthopaedic Surgery, 2019
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Postdoctoral FellowWashington University in St. Louis School of Medicine, Orthopaedic Surgery, 2015
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PhDColorado State University, Fort Collins, 2013
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MSMichigan Technological University, Houghton, 2008
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BSMichigan Technological University, Houghton, 2006
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberBiosciences Initiative
My multi-disciplinary background spans the fields of mechanical and biomedical engineering with additional training in metabolic diseases and immunology. My research expertise includes multi-scale biomechanics, inflammation, and musculoskeletal disease modeling. My research is focused on:
1. Musculoskeletal tissue pathophysiology and mechanics
2. Exercise and overuse mechanobiology of connective soft tissues (e.g. tendons, ligaments, etc.)
3. Engineering immune-stromal crosstalk during the inflammatory response
Department Profile
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Song L, Golman M, Abraham AC, Zelzer E, Thomopoulos S. FASEB J, 2024 Mar 31; 38 (6): e23568Journal ArticleA role for TGFβ signaling in Gli1+ tendon and enthesis cells.
DOI:10.1096/fj.202301452R PMID: 38522021 -
Kent RN, Jewett ME, Buck TP, Said M, Hold LA, Crawford EA, Killian ML, Abraham AC, Huang AH, Baker BM. Adv Healthc Mater, 2024 Mar 5; e2400529Journal ArticleEngineered Microenvironmental Cues from Fiber-Reinforced Hydrogel Composites Drive Tenogenesis and Aligned Collagen Deposition.
DOI:10.1002/adhm.202400529 PMID: 38441411 -
Steltzer SS, Abraham AC, Killian ML. Curr Osteoporos Rep, 2024 Feb 15;Journal ArticleInterfacial Tissue Regeneration with Bone.
DOI:10.1007/s11914-024-00859-1 PMID: 38358401 -
Burt KG, Kim MKM, Viola DC, Abraham AC, Chahine NO. 2023 Aug 8;PreprintNuclear Factor Kappa B Over-Activation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration.
DOI:10.1101/2023.08.07.552274 PMID: 37609194 -
Ganji E, Lamia SN, Stepanovich M, Whyte N, Goulet RW, Abraham AC, Killian ML. Sci Adv, 2023 Jun 23; 9 (25): eadf4683Journal ArticleOptogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice.
DOI:10.1126/sciadv.adf4683 PMID: 37352350 -
Ahmady A, Rosenthal L, Abraham AC, Parker B, Brooks JT, Cahill PJ, Smith JT, Sponseller PD, Sturm PF, Li Y, Pediatric Spine Study Group . J Pediatr Orthop, 2023 May; 43 (5): e319 - e325.Journal ArticleComparison of Distal Spine Anchors and Distal Pelvic Anchors in Children With Hypotonic Neuromuscular Scoliosis Treated With Growth-friendly Instrumentation.
DOI:10.1097/BPO.0000000000002376 PMID: 36827606 -
Kent RN, Said M, Busch ME, Poupard ER, Tsai A, Xia J, Matera DL, Wang WY, DePalma SJ, Hiraki HL, Killian ML, Abraham AC, Shin JW, Huang AH, Shikanov A, Baker BM. Advanced Functional Materials, 2022 Nov 24; 32 (48):Journal ArticlePhysical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels
DOI:10.1002/adfm.202207556 -
Vervaecke AJ, Carbone AD, Abraham A, Bernstein Z, Laudier D, Verborgt O, Galatz LM, Huang AH. J Shoulder Elbow Surg, 2022 Nov; 31 (11): 2366 - 2380.Journal ArticleTendon progenitor cells as biological augmentation improve functional gait and reduce scar formation after rotator cuff repair.
DOI:10.1016/j.jse.2022.05.004 PMID: 35671924