Dr. Kozloff is the Steven A. Goldstein, PhD, Collegiate Professor in Orthopaedic Surgery at the University of Michigan. Dr. Kozloff performed his undergraduate studies in Materials Science and Engineering at the University of Michigan, followed by doctoral training in Biomedical Engineering. After receiving his PhD from the University of Michigan, Dr. Kozloff completed a post-doctoral fellowship at the Center for Molecular Imaging Research at Massachusetts General Hospital and Harvard Medical School in Boston, followed by additional post-doctoral training in the Bone Cell Biology Laboratory of the Department of Orthopaedic Surgery at Boston Children’s Hospital.
In 2007, Dr. Kozloff returned to Ann Arbor and joined the faculty of the Department of Orthopaedic Surgery as part of the Orthopaedic Research Laboratories. Dr. Kozloff’s research focuses on the regulation and measurement of bone mass and quality as it relates to diseases of genetic, hormonal, or mechanical origin. Dr. Kozloff’s laboratory utilizes molecular imaging strategies and biomechanical tools to visualize and quantify bone mass, bone cell activity and skeletal drug delivery in models of low bone mass and tissue regeneration, with an emphasis on the rare bone disease, osteogenesis imperfecta. Pediatric diseases such as osteogenesis imperfecta pose unique challenges given the complex interplay between skeletal growth and bone fragility, and Dr. Kozloff’s laboratory has advanced the field in understanding how new pharmacologic modulators of bone metabolism may benefit diseases such as OI.
In 2020, Dr. Kozloff was appointed Associate Director of the University of Michigan Exercise and Sport Science Initiative, where he works to foster innovative and cross-disciplinary sport and exercise science research on campus. Parallel to this effort, Dr. Kozloff has applied his knowledge of bone physiology and skeletal metabolism to translational questions surrounding bone injury and adaptation in sport and is interested in using information from wearable devices to add predictive knowledge for maximizing positive performance metrics while minimizing negative outcomes such as injury.
Dr. Kozloff has been recognized with Young Investigator awards from the Society for Molecular Imaging, the Orthopaedic Research Society, and the American Society for Bone and Mineral Research. He is a past member of the Board of Directors of the Orthopaedic Research Society. His trainees have also received honors from the Sun Valley Workshop on Skeletal Tissue Biology, the International Society of Biomechanics, the American Society for Bone and Mineral Research, the Orthopaedic Research Society, the Endocrine Fellows Foundation, the European Connective Tissue Society, the Osteogenesis Imperfecta Foundation, and the Fulbright U.S. student outreach program. Dr. Kozloff holds an additional appointment in the Department of Biomedical Engineering and lectures to students and residents on topics related to biomechanics and skeletal physiology.
Areas of Interest
Osteogenesis imperfecta, bone fragility, and therapeutic development and application.
Osteoporosis, bone quality, and novel imaging techniques.
Bone fracture susceptibility and skeletal repair.
Human performance, training, and positive and negative adaptations to training load.
Education and Credentialing
Degree Ph.D., 2005, University of Michigan
Fellowships Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School. 2005-2007 Department of Orthopaedic Surgery, Children’s Hospital Boston, Harvard Medical School. 2007