J. Chad Brenner, Ph.D.

J. Chad Brenner, Ph.D.

Assistant Professor, Department of Otolaryngology-Head and Neck Surgery
Director, Michigan Otolaryngology and Translational Oncology Laboratory

9301B MSRB3
1150 E. Medical Center Dr.
Ann Arbor, MI 48109

734-763-2761

Biography

Dr. Brenner is an assistant professor in the Department of Otolaryngology-Head and Neck Surgery. He is also a member of the U-M Comprehensive Cancer Center. His lab, the Michigan Otolaryngology and Translational Oncology lab (MiOTO), aims to identify new diagnostic tests and precision medicine therapies for cancer patients.

In addition to receiving his undergraduate degree in biomedical engineering from the University of Michigan, Dr. Brenner also received a master's in engineering in bioelectrical engineering and  a doctorate in cellular and molecular biology for his seminal contributions to molecular mechanisms of prostate cancer progression and therapeutic inhibition of the disease.

Areas of Interest

Dr. Brenner's research is focused on functional genomic, proteomic and bioinformatics approaches to study cancer for the purposes of understanding cancer biology as well as to discover novel therapeutic approaches (precision medicine).  His group has discovered driving lesions in prostate cancer and sinonasal undifferentiated carcinomas of the head and neck. Current studies are focus on sequencing the exomes and transcriptomes of head and neck cancer patients with the goal of identifying open clinical trials that may benefit the individual patient. Additional research is focused on identifying drug sensitivities for specific genomic aberrations that are common in cancer. Dr. Brenner's previous work led to the identification PARP inhibitor sensitivities of tumor cells harboring ETS gene fusions (including prostate cancers and Ewing's sarcoms). This finding potentially redefines the clinical therapeutic course of prostate cancer and Ewing's sarcoma and clinical trials are currently underway to test the hypothesis. Currently efforts are underway to extend this molecular medicine approach to head and neck cancers.

Honors & Awards

Dr. Brenner has received a number of awards including the Lindau-Nobel Graduate Student Award, the American Association for Cancer Research Scientist in Training in Award, and the Prostate Cancer Foundation Young Investigator Award.

Published Articles via Michigan Experts or PubMed

Web Sites