Currently Recruiting Studies

Are you interested in participating in research? Explore the studies below for more information

University of Michigan Genomics Initiative (MGI)

All pre-operative patients 18 years of age or older are eligible for participation in the University Biorepository. The biorepository, is a genetic library for researchers at University of Michigan and at other research institutions, including the National Institute of Health to use for several types of studies. Participation includes a small blood sample on the day of surgery and filling out a short questionnaire regarding pre-operative pain and basic lifestyle questions. Patients may be contacted in the future for any study that is conducted through the biorepository. Blood samples are sequenced for the genome/genetic material and stored securely at the University of Michigan.

All Pre-operative patients 18 years of age or older are eligible for participation.

Contact information for participant inquiries:  734-232-0320


Analgesic outcomes Study (AOS)

Any patient who is receiving a first time total knee or hip arthroplasty is eligible for this study. Patients encountering a hysterectomy, some breast surgeries and some thoracic surgeries are also eligible. Patients must be 18 years of age or older. This study entails filling out 10-15 minutes worth of questionnaires pre-operatively about pre-operative pain and overall health and well-being.  Participation also includes a follow-up phone call at the two week and three month post-operative dates, as well as a packet in the mail and a phone call on the six month post-operative date. Phone call follow-ups are typically less than 10 minutes. The packet that is sent in the mail is very similar to the packets filled out on the day of surgery. 

Contact information for participant inquiries: 734-232-0320


Advancing The Treatment of Chronic Pain through Individualized Opioid Cessation

Opioid use in the context of pain management is a complex issue. Recent guidelines recommend against using long-term opioid therapy for most patients with chronic pain and strongly encourage the use of non-opioid interventions.  Opioid cessation programs need to be informed by and tailored to chronic pain patients’ unique needs, however there is a lack of research exploring opioid use and cessation from the patient’s perspective. We hypothesize that understanding patients’ thoughts and emotions regarding opioid use and identifying potential barriers to opioid cessation will be instrumental in helping us develop a patient-centered intervention. This study will enroll 300 patients at the Back and Pain Center and the Fibromyalgia Patient Education Workshop.  Current and former opioid users may be eligible to participate.  This study involves completing questionnaires and structured interviews as well as focus groups and in-depth interviews scheduled at a future date for some participants.  Participation will last about a half hour for the questionnaires and structured interviews, and an additional half hour to two hours for the follow up in-depth interviews and focus groups. The aim of the study is to use patients’ own experiences to develop effective interventions to help patients stop using opioids.

Contact information for participant inquiries:  734-763-5226



Cannabis Study 

In America, many states have legalized cannabis for medical use. Chronic pain is one area in which cannabis is used medically, but there is limited literature assessing on how it used for treatment in chronic pain, and patient beliefs/norms regarding its use. We will obtain a better understanding about cannabis and its role in a chronic pain patient population.

The main goal of this study is to assess patient behavior, beliefs and attitudes regarding medical cannabis use via an online survey. This is to help better understand mood, pain management, cannabis use, and associated outcomes. Survey responses will not be linked with personal identifying information.

Aim 1: To help better understand the role of cannabis in chronic pain

Aim 2: Further cannabis research and health outcomes using the drug

Aim 3: Introduce research findings to day-to-day clinical care

Contact information for participant inquiries:  734-763-5226


Michigan Body Map (MBM)

Body maps have been used for many decades to assess the locations of pain complaints. However, the format of most body maps does not easily allow providers to easily quantify a patient’s painful areas. Given the increasing understanding of the pathophysiology of centralized pain conditions, in which widespread body pain is a common symptom, accurately assessing and quantifying body pain has important implications for research and clinical care. We created the Michigan Body Map as a means of assessing widespread body pain alone and together with the Symptom Severity Index for the 2011 Fibromyalgia Survey Criteria. The Michigan Body Map (MBM) has been validated in the paper format, and now is being validated in the electronic format via Qualtrics. Additionally, patients are being asked to indicate their pain severity in each body zone in which they report having pain.   The MBM is a valid, useful and reliable measure of widespread body pain. We hypothesize the electronic version of the MBM will be just as reliable as the paper version of the MBM, and that using body zones to define pain severity will add a reliable, useful dimension for patients to report their pain to the current measure. After a brief screening and consent process, patients are given the paper MBM and the electronic MBM. Patients are randomized to the order that they receive the body maps. A brief cognitive interview is conducted after the completion of both questionnaires to assess the subject’s understanding and perceptions of the two forms.  After this, patients will be asked to rate their pain severity in the body zones they select on the body map, and complete a second cognitive interview to assess their understanding and perception of the pain severity scale and the body zones.

Contact information for participant inquiries: 734-763-5226


Positive Piggy Bank

All patients meeting study criteria are contacted by research staff to be invited to participate in this study. Patients are recruited from University of Michigan’s Back and Pain Center as well as the Physical Medicine and Rehabilitation Clinic. Before their scheduled procedure, they learn more about the study and provide informed consent if they choose to participate. Participants complete the study questionnaires and are randomized 1:1 to the Positive Piggy Bank or the Wait List control group. This study involves noting at least one positive event each day, writing it down on a slip of paper and then depositing this piece of paper in a piggy bank. At the end of the “deposit period,” in the case of this study after 30 days, the participant “closes the account” and makes a full withdrawal by taking all of the slips out of the piggy bank and reading each one.  This intervention builds on eliciting other well-studied concepts such as positive daily reflection, gratitude and savoring. We hypothesize that patients with back pain who undergo an epidural steroid injection and complete the Positive Piggy Bank intervention will demonstrate a greater improvement in functional status compared to those who undergo the epidural steroid injection alone. All participants complete questionnaire follow ups by mail 1 month and 3 months after his or her procedure. After the study period, the patients in the Wait List control are offered the Positive Piggy Bank intervention.

Contact information for participant inquiries: 734-763-5226


Promoting Resilience through Innovative Self-Management for Chronic Pain (The PRISM study)

Patients with chronic back pain and fibromyalgia will be recruited from the University of Michigan’s Back and Pain Center. 

The study explores how patients can self-manage chronic pain through resilience and cognitive behavioral training. The study will enroll 300 patients. Participation includes 4 visits over the course of one year, which includes a fasting blood draw and answering questionnaires. The patients are then randomized into three groups. One group will be standard of care. The other two groups will participate in an online 8-week program from home between visit 1 and visit 2. During this time, these groups will also work with a pain coach once a week (15-minute phone calls). This program will include activities like learning how to better pace you daily activities, improving sleep and learning relaxation techniques. 

Contact information for participant inquiries:  734-763-5226


Pain and Social Experiences (PASE) Project

Patients at Michigan Medicine will be recruited to complete a one-time, online survey.  This survey will explore the role of positive and negative social experiences in the experience of pain. Eligible participants will be emailed the survey, which will take approximately 1 hour to complete.  Participants will also be given the opportunity to be included in registry to be contacted about future studies.

Contact information for participant inquiries:  734-763-5226