Intramural Funding Opportunities

FOR FACULTY

Pediatric Intramural Research Funding Program

The Department of Pediatrics manages a portfolio of philanthropic funds designated to support research in pediatrics. Proposals are solicited twice per year; Winter/Spring and Summer/Fall cycles.  See submission details and current RFA posted below.

HOW and WHEN TO APPLY

A research funding announcement (RFA) will be circulated approximately 6-8 weeks before the due dates highlighting any program changes and detailed submission information. Applications are accepted through Competition Space.
*Download RFA:  Pediatrics _Intramural_RFA_SF2020.docx

Application due dates:
Winter/Spring Cycle 2020 - completed
Summer/Fall Cycle 2020 -  October 5, 2020 - completed

Questions/Contact:
Jackie Torres: 763-9150; jjtorres@umich.edu
Pediatric Research Office:  615-1740; pedsresearch@umich.edu

FUNDING and IMPLEMENTATION POLICIES

Eligibility

  • Only faculty with primary appointments in the Department of Pediatrics are eligible to serve as Principal Investigators (with exception of the Charles Woodson Collaborative Research Award, see separate RFA).
  • UM faculty from other Medical School departments may submit applications for the Charles Woodson Collaborative Research Award under a MPI format with Pediatrics faculty (see separate RFA).
  • Residents and fellows are not eligible to serve as Principal Investigators.
  • Faculty may submit only one application per cycle, as Principal Investigator. However, a Woodson Biostatistics Award application may be submitted in addition to the single application.
  • Applicants may resubmit revised applications that were not funded in the prior cycle.

Funding Restrictions

  • Unless otherwise stated, funds may be used for University of Michigan research personnel salary support, supplies, and research equipment.
  • Award funds may not be used to support any UM faculty member, cost overruns or retroactive funding, publications, grant preparation costs, travel, hosting, renovations, office equipment, GSRA tuition, external collaborator or consultant salaries, membership dues, or indirect costs (F&A).
  • Clinical trials that require a billing calendar are not eligible for funding.  Projects that involve collaboration, shared funding, or data sharing with commercial entities (i.e., academic-industry partnerships) are not eligible for funding.

Human Subjects / Animals

  • Funds for research proposals that require IRB or IACUC approval will not be released until documentation of IRB or IACUC approval is provided to the Pediatric Research Office, along with any substantial changes to the proposed research required by the IRB or IACUC. 
    *Note: Regulatory approvals must be acquired within 6 months of award notification; grants may not have ‘delayed start’ past 6 months.

Project Period(s) 

All intramural awards will have an end date by which funds must be expended.

  • Awards < $30,000 must be expended within 1 year of disbursement of funds
  • Awards =/> $30,000 must be expended within 2 years of disbursement of funds
  • Faculty may request a 1-year extension beyond these time periods; written requests for extensions must be submitted by to the Pediatric Research Office for approval 3 months prior to the award end date.
  • Funds that are not expended within the award project period will be returned to the Department of Pediatrics.

Reporting

  • Awardees are required to submit post-funding (12-month) progress reports,
  • acknowledge the funding mechanism in research publications or presentations, and
  • present research at the annual Pediatric Research Symposium.

Award Mechanisms

Mechanisms Only for Mid-Career or Junior Faculty in the Department of Pediatrics

  • Gorman Scholar Award ($30,000): Must be at the rank of Lecturer, Instructor, Assistant Professor, or Associate Professor. The award is potentially renewable for an additional year. The award is potentially renewable for an additional year. The award must lead to submission of a new external grant application within 18 months of funding.

  • Janette Ferrantino Investigator Award ($40,000): Must be at the rank of Lecturer, Instructor, or Assistant Professor and be within the first three years of appointment at the University of Michigan. The award is potentially renewable for an additional year.

  • Elizabeth E. Kennedy (Children’s Research) Award ($20-50,000): Must be at the rank of Lecturer, Instructor, or Assistant Professor. Areas of particular interest include developmental biology, genetic and translational research.

 Mechanisms for Faculty of any rank with a Primary Appointment in the Department of Pediatrics

  • Charles Woodson Pilot Research Award ($15-50,000): This award is to support innovative pilot projects in pediatric/children’s health research.

  • Charles Woodson Collaborative Research Award (see separate RFA).

  • Charles Woodson Biostatistics Award (up to $10,000): This award supports costs for consultation with relevant experts in study design and data analysis for new and on-going clinical, translational, or health services research projects. Funds can be used to support biostatistical consultation within the University of Michigan.

  • Children’s Health Research Award ($15-50,000): This award supports high merit, innovative pilot projects in pediatric/children’s health research.

  • Amendt-Heller Award for Newborn Research ($15-50,000): This award supports newborn research.

  • James and Lynelle Holden Research Award ($15,000): This award supports newborn research or research being conducted within the Holden Research Laboratories.

  • Benz Birth Defects Research Award ($50,000): This award supports birth defects research.

  • Nancy Newton Loeb Pediatric Cancer Research Award ($25-50,000): This award supports cancer research.

  • Gracie’s Fund – Leukemia Research Award ($20-50,000): This award supports leukemia research (especially relapsed and complicated leukemias). 

Charles Woodson Collaborative Research Award

The University of Michigan (UM) Department of Pediatrics manages the Charles Woodson Collaborative Research Award, which is designated to support research in pediatrics. There are two peer-review competition cycles annually. The Charles Woodson Collaborative Research Award focuses on support for innovative pilot projects in children’s health research through an interdisciplinary team approach that includes faculty from Pediatrics and other UM Medical School departments in a “Multiple Principal Investigator” approach. The award is $50,000. The primary goal is to support innovative collaborations that will be highly competitive for new extramural (federal and foundation) funding. See separate RFA below; applications are accepted through Competition Space.

*Download RFA: CWoodson_Collaborative RFA_SF2020.docx

Winter/Spring Cycle 2020 - completed
Summer/Fall Cycle 2020 -  October 5, 2020 - completed

Questions/Contact:
Jackie Torres: 763-9150; jjtorres@umich.edu
Pediatric Research Office:  615-1740; pedsresearch@umich.edu

Eligibility:

  • There must be two* Principal Investigators (PI’s), each of whom brings separate but complementary expertise to a research topic relevant to children’s health. (*Applications may have 3 PIs.)
  • One of the PI’s must be a faculty member with a primary appointment in the Department of Pediatrics.
  • UM faculty with primary appointments in other Medical School departments may submit applications for the Charles Woodson Collaborative Research Award under a multiple PI (as defined by NIH) format with Pediatrics faculty.
  • Residents and fellows are not eligible to serve as Principal Investigators.
  • Faculty may submit only one application per cycle, as Principal Investigator.
  • Applicants may resubmit revised applications that were not funded in the prior cycle.

 Funding restrictions:

  • Unless otherwise stated, funds may be used for University of Michigan research personnel salary support, supplies, and research equipment. Budget requests must be justified.
  • Award funds may not be used to support any UM faculty member, cost overruns or retroactive funding, publications, grant preparation costs, travel, hosting, renovations, office equipment, GSRA tuition, external collaborator or consultant salaries, or indirect costs (F&A).
  • Clinical trials that require a billing calendar are not eligible for funding.  Projects that involve collaboration, shared funding, or data sharing with commercial entities (i.e., academic-industry partnerships) are not eligible for funding.
  • Funds that are not expended within 3 years of the award date will be returned to the Department of Pediatrics. 

Funded Projects

Summer/Fall 2019

  • Gorman Scholar Award: Kao-Ping Chua, MD, PhD (CHEAR)
    Naloxone Prescribing and Dispensing Among Adolescents and Young Adults at High Risk of Opioid Overdose.  In 2016, 2,985 adolescents and young adults aged 15-24 years died of an overdose related to prescription or illicit opioids, representing a rate of 1 death every 11 minutes.1 To mitigate the risk of these overdose deaths, it is crucial to ensure that adolescents and young adults at high risk of opioid overdose have access to naloxone, a medication that can save lives by rapidly reversing overdose. However, it is unknown how frequently these patients are prescribed naloxone, how often naloxone prescriptions for these patients are dispensed at pharmacies, and whether out-of-pocket costs are a barrier to naloxone dispensing. In this proposal, I will use insurance claims databases and national prescription data to assess naloxone prescribing and dispensing among high-risk adolescents and young adults and to evaluate whether out-of-pocket costs deter naloxone dispensing. The results from this study will inform the design and implementation of interventions to increase naloxone use and reduce overdose deaths among high-risk adolescents and young adults. Additionally, results will also inform whether insurers should eliminate out-of-pocket costs for naloxone.
  • Janette Ferrantino Investigator Award: Louis Dang MD, PhD (Pediatrics Neurology).
    Targeting upstream open reading frames to amplify haploinsufficient SCN1A expression.  Dravet Syndrome (DS) is a devastating disease affecting children who suffer from severe seizures, developmental regression and a high risk of premature death. DS is caused by a mutation in the SCN1A gene, resulting in decreased levels of its protein product, Nav1.1. It is observed that the normal SCN1A gene has multiple “false” protein synthesis start sites which would result in decreased efficiency of Nav1.1 protein synthesis. An antisense oligonucleotide that targets and blocks the “false” start sites and may result in increased production of the crucial Nav1.1 protein. We intend to use a human stem cell model of DS to determine whether targeting the “false” protein synthesis start sites in the SCN1A gene with antisense oligonucleotides can result in increased production of the Nav1.1 protein. This therapeutic strategy has the potential of preventing or halting the progression of seizures and cognitive impairment in patients with DS as it addresses the underlying cause.
  • Ravitz Advancement Award: Suzanne Dawid, MD, PhD (Pediatrics Infectious Diseases).
    The role of competitive pneumococcal loci in invasion of the airway microbiome: Streptococcus pneumoniae is a common cause of middle ear infections, pneumonia and meningitis primarily affecting young children and the elderly population. The bacteria reside in the nasal cavity, and from there passes from person to person, typically causing no symptoms until there is a breach in host barriers. The nasal cavity is filled with a diverse and varied community of bacteria that all compete to survive in each human host. These competitive interactions are vital for persistance of this pathogen but are very poorly understood. This research focuses on creating a new model that uses human saliva to establish a complex bacterial community that we can use to study the competitive interactions that allow Streptococcus pneumoniae to continue to be a serious cause of human disease.
  • Elizabeth E. Kennedy Children’s Research Award: Zubin J. Modi, MD (Pediatrics Nephrology).
    Identification of pediatric chronic kidney disease and health services use in a national cohort.  Kidney disease in children is a devastating, lifelong condition. It is thought that childhood kidney disease is a rare problem Using data from insurance claims can help us better understand how many children have kidney disease. Unfortunately, we currently have many ways to identify these children, but do not know which way is best. This study will start to answer the question of what method of using insurance claim data for pediatric kidney disease research is best. We will compare the way different methods capture children with kidney disease to estimate how many US children have kidney disease, what health services they use, and if we can track worsening kidney disease over time.
  • Charles Woodson Biostatistics Award. Jenny  Radesky, MD.
    Understanding Early Childhood Media Use Profiles. Young children’s access to modern digital media, such as smartphones and tablets with interactive applications, has been increasing rapidly over the past 10 years. Past research has looked at children’s media use behaviors in isolation; for example, testing whether total ‘screen time’ duration is linked with developmental delays. However, children’s modern media usage is far more complex than a single ‘screen time’ concept; therefore, research needs to take into account the multiple layers of media use in a child’s environment, such as the design of the apps they use, how much media parents use, and family rules and engagement around media in the home. This study proposes to use statistical modeling to define preschoolers’ Media Profiles – a novel concept that captures the multitude of ways media is used by families – and examine how these profiles correlate over time and with family characteristics.

Winter/Spring 2019

  • Charles Woodson Collaborative Research Award: Catherine Keegan, MD, PhD (Pediatrics Genetics) and Stephen Parker, PhD (Computational Medicine and Bioinformatics).
    Single-cell resolution developmental regulatory mapping of caudal structural birth defects.   Birth defects are the leading causes of infant mortality in the United States accounting for 1 in 5 infant deaths. Affected children who do survive often endure numerous corrective surgeries causing emotional and financial stresses to many families. Birth defects involving the caudal, or lower half of the body, affect the reproductive organs, kidneys, spine, stomach, intestines, and the lower limbs. Caudal birth defects are well recognized clinically, though the biological processes behind them are currently not well understood. This research project integrates the use of mice carrying specific genetic changes to model caudal birth defects and cutting-edge genomic technologies to learn how individual cells behave in normal and abnormal development. The results of our studies will translate into increased knowledge of normal human development and allow for better counseling, diagnosis, and treatment for patients and families affected by this class of birth defects.
  • Amendt-Heller Award for Newborn Research. John Charpie, MD, PhD (Pediatrics Cardiology),
    Nicorandil attenuates cardiomyocyte injury and ventricular dysfunction after cardiopulmonary bypass. Early cardiac failure after open heart surgery in children is a relatively common phenomenon that is associated with major complications and death.  The precise causes for cardiac failure are incompletely understood, but the heart-lung bypass machine and relatively brief period of interrupted blood flow to the heart muscle that are necessary for surgical repair clearly contribute.  Nicorandil, a drug approved for use in adults with chest pain, appears to have protective effects against early cardiac failure in adult animal models.  We plan to evaluate the potentially beneficial effect of nicorandil in a young animal model of open heart surgery in preparation for a clinical trial in human infants.
  • Benz Birth Defects Research Award. Shane Quinonez, MD (Pediatrics Genetics). 
    Agricultural Pesticide Exposure and the Risk of Neural Tube Defects in Rural Ethiopia.  Birth defects and genetic diseases are increasing in importance as causes of lifelong disability and mortality in low- and middle-income countries. A well-known and preventable cause of birth defects is the exposure of pregnant women to agricultural pesticides and other environmental toxins. In areas surrounding flower farms in rural Ethiopia, local health care providers have reported an increased occurrence of a serious birth defect affecting the central nervous system known as neural tube defects. In this research proposal, we aim to use a mobile application called the MiGene Family History App to study if there is an association between occupational and/or residential exposure to flower farming pesticides and neural tube defects. This study has important implications for the rural population of Ethiopia and will bring increased attention to the care of underserved populations. 
  • Charles Woodson Pilot Research Award. Prachi E. Shah, MD, MS (Developmental-Behavioral Pediatrics).
    Parent and Teacher Antecedents of Curiosity, Associations with Academic Achievement at KindergartenIn the young child, curiosity, combined with a strong drive to master new information, provides a solid foundation for early learning, but the expression and promotion of curiosity may vary with the quality of early experiences, which may contribute to disparities in academic achievement. Our previous work has identified that higher curiosity in early childhood is associated with higher academic achievement in kindergarten, and can potentially close the achievement gap associated with poverty. To date, little is known about the conditions in the home and early learning environments which can foster early childhood curiosity, especially for children in poverty. This application will identify the types of early experiences at home and at kindergarten which can foster curiosity and academic achievement in young children, with special attention to the role of these experiences for children with socioeconomic disadvantage. This work can lead to the development of interventions, policies and practices to promote the expression of curiosity in young children, to potentially mitigate the achievement gap associated with poverty.
  • Charles Woodson Biostatistics Award.  Lindsay Ellsworth, MD and Brigid Gregg, MD (Pediatrics Endocrinology).
    Infant Metabolism and Gestational Endocrinopathies (IMAGE) StudyInfant Metabolism and Gestational Endocrinopathies (IMAGE) Study. Maternal metabolic diseases are becoming increasingly common during pregnancy which can impact maternal and infant health. This research study is being done to look at levels of nutrients, hormones and bioactive factors in breast milk from mothers with obesity, diabetes and polycystic ovary syndrome as well as maternal urine, infant stool and infant saliva. Our goal is to better understand the many factors that impact how mother’s health influences infant’s health during the lactation period. 

Summer/Fall 2018

  • Amendt-Heller Award for Newborn Research. Kimberly Monroe, MD, MS (Hospital Medicine).
    Epidemiology and Risks of Alternative Perinatal Practices: Establishing a National Registry for Vitamin K Deficiency Bleeding and Lotus Birth (Umbilical Non-Severance) Cases.  Vitamin K refusal and umbilical non-severance are alternative newborn practices currently practiced in this country without a mechanism to track outcomes. Vitamin K refusal can infrequently lead to vitamin K deficiency bleeding (VKDB). Umbilical non-severance is a birth practice without evidence to support its safety. Umbilical non-severance can, theoretically, lead to hyperbilirubinemia and/or infection. A national registry to track outcomes does not exist for either practice. By establishing a national registry, we will be able to track the rates of vitamin K refusal, VKDB, umbilical non-severance, and infection and hyperbilirubinemia associated with umbilical non-severance. Characteristics associated with vitamin K refusal and umbilical non-severance will also be tracked. Since the frequency of vitamin K refusal, VKDB, and lotus births in hospitals is low (6 cases of lotus births/~8000 deliveries at U of M), gathering data on a national scale is essential to increase the sample size. This registry will ultimately give practitioners the evidence needed to provide safe, patientcentered care when a lotus birth is desired. The registry will also allow for a more accurate understanding of the scale of vitamin K refusal and VKDB; leading to greater opportunities to address this unsafe alternative. This would be the first national registry of rates of vitamin K refusal, VKDB, and lotus births. The University of Michigan Pediatric Hospital Medicine and General Pediatrics Divisions will be national leaders in this area. Development of the registry comes after a recent publication in Contemporary Pediatrics and acceptance of a manuscript to Clinical Pediatrics; as well as a very well received presentation at the Pediatric Hospital Medicine Conference in Atlanta on alternative birth practices. In addition, University of Michigan physicians wrote Senate Bill 1075.
  • Janette Ferrantino Young Investigator Award. Erin Carlton, MD (Critical Care Medicine).
    New Morbidity and Healthcare Utilization after Pediatric Severe Sepsis.  Severe Sepsis, the body’s overwhelming and life-threatening response to infection, hospitalizes more than 75,000 children each year and while survival rates have improved dramatically, the long-term effects of sepsis beyond hospital discharge remain largely unknown. Using large, nationally representative datasets, I will determine the impact of severe sepsis by evaluating the rate of new medical device dependence (i.e. tracheostomy or gastrostomy tube) and new chronic conditions (i.e. the development of chronic kidney disease) in children hospitalized for severe sepsis. Additionally, I will define the change in healthcare utilization, specifically, repeat hospitalizations, outpatient clinic visits and presentation to the emergency department, after severe sepsis. By understanding the impact of severe sepsis after the initial event, we can then work to identify children at highest risk and intervene to prevent the lasting impact of sepsis.

 Winter/Spring 2018

  • Charles Woodson Pilot Research Award. Albert Rocchini, MD / Stephanie Goldstein, MD (Cardiology).
    Colchicine in postoperative Fontan patients. Primary Objective: Determine if Colchicine is associated with decreased inflammatory cytokines (TNF-α) within the pleural space in post-operative Fontan patients compared to a historical cohort of Fontan patients. Secondary Objective: 1. Examine the cytokine concentrations in Fontan patients treated empirically with Colchicine in comparison to a cohort of Fontan patients at a given time-point postoperatively. 2. Determine if Colchicine is associated with decreased duration of pleural drainage in post-operative Fontan patients compared to a cohort of Fontan patients 3. Determine if Colchicine reduces hospital length of stay following Fontan procedure.   
  • Charles Woodson Pilot Research Award. Sung W. Choi, MD, MS (Hematology/Oncology)
    Vorinostat for GVHD Prevention in Children and Adolescents Undergoing Allogeneic BMT
  • Charles Woodson Pilot Research Award. Matthew G. Sampson, MD, MSCS (Nephrology)
    Biobank to Illuminate the Genomic Basis of Rare Disease ("BIGBiRD")
  • Charles Woodson Pilot Research Award. Megan H. Pesch, MD (Developmental-Behavioral Pediatrics)
    A qualitative and quantitative evaluation of primary care physicians’ perceptions of and responses to faster patterns of growth in infancy.
  •  Janette Ferrantino Young Investigator Award. Kao-Ping Chua, MD, PhD (Child Health Evaluation & Research Center). 
    A National Profile of Opioid Prescriptions to Children
  •  Amendt-Heller Newborn Research Award. Antonia Popova, MD (Pulmonary Medicine). 
    Elucidating the Role of Lung Exudative Macrophages in Chronic Neonatal LPS Exposure-Induced Pulmonary Inflammation and Hypoalveolarization
  •  Children's Health Research Award. Heang M. Lim, MD (Cardiology). 
    Quality of Life and PTSD in Pediatric Cancer Survivors With Chemotherapy-Related Cardiac Dysfunction
  • Benz Birth Defects Research Award. Catherine Keegan, MD, PhD (Genetics, Metabolism & Genomic Med).
    Identification of direct targets of ectopic Ptf1a expression in Danforth's short tail mice

 

FOR RESIDENTS and FELLOWS ---- Summer/Fall 2020 cycle deadline extended to November 30, 2020

Resident and Fellow Research Grant Program 

 The Department of Pediatrics Resident and Fellow Research Grant Program is intended to support the research career development of residents and fellows in the Department of Pediatrics. The Department will accept funding requests on a biannual basis. Review of proposals will be coordinated by the Associate Chair for Education, in collaboration with the Associate Director of Fellowship Programs, Residency Program Director, and Associate Chair for Research. 

Eligibility: House Officers with Primary Appointments in the Department of Pediatrics proposing a pediatric-focused research topics. Eligible trainees include:

  • Pediatric Residents
  • Internal Medicine-Pediatric Residents
  • Pediatric Neurology Residents
  • Pediatric Subspecialty Fellows

Funding: Up to $1000 for residents, Up to $5000 for fellows.

Funding Restrictions: Unless otherwise stated, funds may be used for University of Michigan research personnel salary support, research supplies, and research equipment. Award funds may not be used to support any UM faculty member, cost overruns or retroactive funding, publications, grant preparation costs, travel, hosting, renovations, office equipment, GSRA tuition, external collaborator or consultant salaries, or indirect costs (F&A). Funds for research proposals that require IRB or IACUC approval will not be released until documentation of IRB or IACUC approval is provided to the Pediatric Research Office, along with any substantial changes to the proposed research required by the IRB or IACUC.

Reporting: All funds must be used within 24 months of disbursal or before the completion of the training program (whichever comes first). The project must be submitted for presentation at the Pediatric Department Research Symposium within 24 months of funding or before the completion of the training program (whichever comes first). 

All applications must also be accompanied by a letter of support from a faculty sponsor with a primary appointment in the Department of Pediatrics, Program Director or Division Director within the Department of Pediatrics.  

Applications are accepted twice yearly with deadlines of September 15th and April 15th (or the first subsequent weekday) by 11:59 PM. Questions and applications should be submitted by email to pedsresearch@umich.edu.   *NOTE: Summer/Fall deadline extended to November 30, 2020.

Contact/Questions: 

Jackie Torres: jjtorres@umich.edu (763-9150)

Pediatric Research Office: pedsresearch@umich.edu (615-1740)

Download application: Resident and Fellow Research Grant Program-RFA_Summer-Fall2020.docx

Funded Projects

Spring 2020

  • Richard Birnbaum, PhD (Pediatric Psychology Fellow; Advisor: Andrew Cook, PhD). Revising and Validating the Parent Acceptance of Pediatric Integrated Care Survey (PAPICS)Revising and Validating the Parent Acceptance of Pediatric Integrated Care Survey (PAPICS)

Fall 2019

  • Jennifer Lai Yee, MD, MPH, PhD (Pediatric Nephrology Fellow; Advisor: Rebecca Lombel, MD). Functionally resolving WT1 variants of uncertain significant in Nephrotic Syndrome.
  • Stephani K. Zakutansky, MD (Medicine-Pediatrics HO-3; Advisor: Erin Carlton, MD).  Analyze mortality outcomes in patients with severe sepsis admitted to PICUs versus MICUs using a single database.

Downloads

Pediatrics Intramural Program, Summer-Fall 2020 RFA
Pediatrics Charles Woodson Collaborative Research Award, Summer-Fall 2020 RFA