Translational Sciences Journal Club and Seminar Series. (1 hr.) Translation of basic science discoveries into clinical practice in the cornerstone of improved healthcare. Learn how scientific advances progress from bench to bedside through literature reports and seminars by experts in academia and industry. The course highlights entry of new small molecules, biologics, devices, diagnostics, etc. into clinical practice. Offered in the fall semester.
Introduction to Translational Science. (2 hr.) This course is designed to introduce the students to the field of translational science and research. The course will serve to expose the students to a variety of topics in translational science including an introduction to the various types of clinical and translational science, various roles of translational scientists and how to put together an effective translational science research team, identification of qualified and impactful mentors at the various stages of training, development of a competitive training plan in clinical and translational science, how to write effective clinical and translational manuscripts, and how to develop your biosketch and CV in order to become competitive in the field of clinical and translational science.
This course will teach concepts related to mechanisms of disease. We will cover pathological mechanisms ranging from the level of the single molecule and the individual cell, all the way up to the whole tissue and organism. Many of the topics discussed in Pathology 581 could easily serve as the focus of an entire dedicated course! The intent of Pathology 581 is not to cover any of these in great depth. Rather it is a survey course that intentionally samples a broad range of topics of interest in modern Pathology.
Advances in life science research have enhanced our understanding of the human genome, human genetic variation, and the role that genes play in our everyday health, response to treatment and susceptibility to disease. This new frontier in genomic medicine ushers in both opportunity and peril for individuals, companies and societies. The objective in this interdisciplinary graduate course is to explore the intersections between science, technology, commerce and social policy as they come together to advance (and in some cases retard) progress toward more-personalized health care. The course is intended for graduate students in medicine, biomedical and health-related science, public health, law, engineering, and business interested in the future of health care. Due to variation in student backgrounds coming into the course, efforts are made to establish a shared vocabulary and knowledge base across the disciplines. Interdisciplinary student teams are assigned to a group research project which is presented at the end of the course.
Biotechnology is a rapidly evolving, multi-disciplinary field that impacts nearly every aspect of our daily lives from the food we eat to the medicine we take. This course covers basic scientific and engineering principles behind this growing field, along with entrepreneurial aspects of translating innovative biotechnological solutions into new products.
Quantitative description of the structure and function of mammalian systems, including the neuromuscular, cardiovascular, respiratory, renal and endocrine systems. Mathematical models are used to describe system performance where applicable. Lectures, laboratories and problem sessions.
This course provides an introduction to the principles and practical approaches of bioinformatics as applied to genes and proteins. The overall course content is broken down into sections focusing on foundational information, statistics, and systems biology, respectively. This course replaces BIOINF 525. Offered Winter term.
Biostatistical analysis provides the means to identify and verify patterns in this data and to interpret the findings in a public health context. In this course, students will learn the basic steps in analyzing public health data, from initial study design to exploratory data analysis to inferential statistics. Specifically, we will cover descriptive statistics and graphical representations of univariate and multivariate data, hypothesis testing, confidence intervals, t-tests, analysis of contingency tables, and simple and multiple linear regression. Offered fall term.
Introduction to Scientific Communication (2 hrs.) This course introduces second-year graduate students to essential scientific communication skills. Students will write a grant over the course of the term on a chosen topic. Class meetings alternate between presentations by local experts and students. In-depth analysis of student writing/presentation skills provided in class by instructor, small groups, and guest scientists. By term's end students will have a high-quality product to be presented in oral and written form. Finally, students will participate in a mock study section to constructively evaluate the grants. Offered in the fall semester.
How do researchers study families or populations of individuals with a genetic disease to identify the disease-associated mutations? How are disease-associated variants transmitted through families and populations? How does a mutation in the human genome lead to a specific disease phenotype? How can this genetic information be used to benefit patient populations? What do genetic diseases tell us about human biology? These are just a few of the questions that Human Genetics 542 (HG542) “Molecular Basis of Human Genetic Disease” addresses using examples from the current and classic literature. HG542 emphasizes concepts including, but not limited to: (i) the nature of human genomic variation; (ii) strategies for mapping disease-associated genetic variation; (iii) the role of the environment in inherited disease phenotypes; (iv) the design and interpretation of experiments to characterize the molecular pathology of implicated mutations; and (v) how these discoveries are moved into the clinic. HG542 is an essential course for anyone interested in molecular genetics and human variation as it relates to human disease.
From Molecules to Patients: Basic Quantitative Principles of Pharmacology.(3 hrs.) This is a graduate level course that examines the fundamental principles of pharmacology and their quantitative treatment as a basis for understanding the properties and mechanism of action of drugs. The course is aimed at, but not limited to students of Pharmacology, Medicinal Chemistry, Chemical Biology, Toxicology, Bioinformatics or Biological Chemistry. Topics include: Structure and physical properties of drugs; quantitative structure-activity and dose-response relationships; receptors as determinants of drug action; concepts, analysis and modeling of agonists, antagonists, and receptor mechanisms; signal amplification, selectivity, and regulation; drug absorption, distribution and metabolism; modern approaches to drug design. Offered in the fall semester.
Science in the Clinics. Prerequisite or corequisite: MICRBIOL 607, 615, 640 or permission of instructor. Course Directors: Vern Carruthers and Adam Lauring. This course brings students into the real world of infectious diseases to help them connect basic pathogenesis research and training with clinical and therapeutic features of infectious disease medicine. The sessions are run by two faculty members, a physician and a basic scientist. Each class begins with a case presentation by the physician, who takes the class through ID cases, including history, laboratory and physical findings, etc. During this discussion, students learn and discuss the meanings of specific clinical findings, learning why different tests are performed and how physicians ultimately build a differential diagnosis. Following the case presentation, an assigned paper is covered in detail by the basic scientist through discussion with the students. The discussion is aimed at interpreting the findings with regard to their basic science implications, in addition to clinical implications in light of the case discussions just carried out.
Translational Pathology is a graduate-level course designed to help meet the growing need for scientists and medical professionals who can bridge the gap between basic science and clinical practice. This multi-disciplinary course trains both graduate students and clinical residents/fellows in the methods and principles involved in translating basic science findings into clinically useful interventions to improve human disease outcomes. The central objective is to illustrate how basic science applied to human disease can lead to the discovery of its pathophysiology, which in turn can be used to develop therapeutics and diagnostic tests. The course is taught from the perspective of the pathologist, wherein faculty experienced with successful translational research offer insight spanning: the nature and manifestation of human disease, the mechanisms of disease pathogenesis, chemical pathology and drug discovery/development, laboratory diagnostics, clinical trials, personalized medicine, and the newest technologies in these arenas. The target mixture of research and clinical trainees enriches the educational experience.
Translational Pharmacology: From Drug Discovery to Therapeutics. (2 hrs.) Experts from academic and industry will take you on a journey from bench science to new therapeutic agents. Students will learn how to translate preclinical studies to clinical trials and FDA approval. Critical evaluation of clinical trials, patent issues and pharmacoeconomics will also be taught. Offered in the fall semester.
Translation Research. (2 hrs.) This course will discuss the pathway from discovery to clinical development for devices, diagnostics, biologics, etc. Issues such as FDA regulations, ethical considerations and affordability will also be addressed. For those considering careers in and outside of academia, this course will help to make informed decisions. Offered in the fall semester.
