Gregory Tall, Ph.D.

Associate Professor

Office: 1220C MSRB III

Lab: 1240 MSRB III

Office: 734-647-9824 Lab:734-763-7154

Areas of Interest

In canonical G protein signaling, G protein coupled receptors (GPCRs) activate heterotrimeric G proteins, which in turn regulate intracellular effector enzymes. Our lab studies G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. We found the biochemical function of one new G protein activator, Ric-8. Ric-8A activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. A major focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell. Observations made in genetic model systems suggest that Ric-8 proteins work with G proteins to regulate asymmetric cell division, the subcellular localization of G protein subunits, and as modulators of traditional GPCR signaling.



Ph.D., Biomedical Sciences, University of Texas southwestern Medical Center, 2000
B.S., Cell Biology/Biochemistry, Bucknell University, 1994

Post-Doctoral Training

Research Fellow, U.T. Southwestern Medical Center, Dallas, TX, 2000-2006

Published Articles or Reviews

Web Sites