Areas of Interest
Roles of Hypoxia and B Lymphocytes in Inflammation, Fibrosis, and Regeneration of the Pancreas;Function of B1 B Lymphocytes in Pancreatic Tumorigenesis; Modeling Pancreatic Diseases with Three-Dimensional Co-Culture System.
Honors & Awards
2014: Top Poster Award at 2014 American Association for Cancer Research, Special Conference on Pancreatic Cancer.
2009: NYU Graduate School of Arts and Science Student Conference Award.
2009: Sackler Institute Travel Grant, New York University School of Medicine.
2003 – 2005: Korea Science and Engineering Foundation Scholarship for Study Abroad.
2003: Magna Cum Laude in the Biological Sciences, KAIST, Korea.
1999 – 2003: Korean Government Scholarship, Ministry of Science and Technology.
Ph.D., Cellular and Molecular Biology,New York University, New York, NY, 09/2010
B.S., Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, 02/2003
Postdoctoral Fellow, Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 12/2010 - 08/2018
Lee KE, Spata M, Maduka R, Vonderheide RH, Simon MC: Hif1α deletion limits tissue regeneration via aberrant B cell accumulation in experimental pancreatitis. Cell Reports, 23:3457-3464, 2018.
Fuming Li*, Lee KE*, Simon MC: Detection of Hypoxia and HIF in Paraffin-Embedded Tumor Tissues. Methods Mol Biol 1742:277-282, 2018. *Equal contribution
Lee KE, Spata M, Bayne LJ, Buza EL, Durham AC, Allman D, Vonderheide RH, Simon MC: Hif1α deletion reveals pro-neoplastic function of B cells in pancreatic neoplasia. Cancer Discovery 6:256-269, 2016.
- In the Spotlight. Cancer Discovery 6:230-232, 2016.
- Research Highlight. Nature Reviews Cancer 16:67, 2016.
- Editors’ Choice. Science Signaling 9:ec77, 2016.
Lee KE, Simon MC: SnapShot: Hypoxia-Inducible Factors. Cell 163:1288-1288.e1, 2015.
Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR: Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest 123:4681-4694, 2013.
Pylayeva-Gupta Y, Lee KE, Bar-Sagi D: Microdissection and culture of murine pancreatic ductal epithelial cells. Methods Mol Biol 980:267-279, 2013.
Lee KE, Simon MC: From Stem Cells to Cancer Stem Cells: HIF Takes the Stage. Curr Opin Cell Biol 24:232-235, 2012.
Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D: Oncogenic Kras-induced GM-CSF production supports the development of pancreatic neoplasia. Cancer Cell 21:836-847, 2012.
Mallen-St.Clair J, Soydaner-Azeloglu R, Lee KE, Taylor LJ, Livanos A, Pylayeva-Gupta Y, Miller G, Margueron R, Reinberg D, Bar-Sagi D: EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev 26:439-444, 2012.
Lee KE, Bar-Sagi D: Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell 18:448-458, 2010.
- Research Highlight In Brief. Nature Reviews Cancer 11:5, 2011.
Agbunag C, Lee KE, Buontempo S, Bar-Sagi D: Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods Enzymol 407:703-710, 2006.