Kyoung Eun Lee, Ph.D.

Assistant Professor

A220D MSRB III

734-936-8770

Areas of Interest

Roles of Hypoxia and B Lymphocytes in Inflammation, Fibrosis, and Regeneration of the Pancreas;Function of B1 B Lymphocytes in Pancreatic Tumorigenesis; Modeling Pancreatic Diseases with Three-Dimensional Co-Culture System.

Honors & Awards

2014: Top Poster Award at 2014 American Association for Cancer Research, Special Conference on Pancreatic Cancer.

2009: NYU Graduate School of Arts and Science Student Conference Award.

2009: Sackler Institute Travel Grant, New York University School of Medicine.

2003 – 2005: Korea Science and Engineering Foundation Scholarship for Study Abroad.

2003: Magna Cum Laude in the Biological Sciences, KAIST, Korea.

1999 – 2003: Korean Government Scholarship, Ministry of Science and Technology.

Credentials

Education

Ph.D., Cellular and Molecular Biology,New York University, New York, NY, 09/2010
B.S., Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, 02/2003

Post-Doctoral Training

Postdoctoral Fellow, Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 12/2010 - 08/2018

Published Articles or Reviews

Lee KE, Spata M, Maduka R, Vonderheide RH, Simon MC:  Hif1α deletion limits tissue regeneration via aberrant B cell accumulation in experimental pancreatitis. Cell Reports, 23:3457-3464, 2018.

Fuming Li*, Lee KE*, Simon MC:  Detection of Hypoxia and HIF in Paraffin-Embedded Tumor Tissues. Methods Mol Biol 1742:277-282, 2018.  *Equal contribution

Lee KE, Spata M, Bayne LJ, Buza EL, Durham AC, Allman D, Vonderheide RH, Simon MC:  Hif1α deletion reveals pro-neoplastic function of B cells in pancreatic neoplasia. Cancer Discovery 6:256-269, 2016.
      - In the Spotlight. Cancer Discovery 6:230-232, 2016.
      - Research Highlight. Nature Reviews Cancer 16:67, 2016.
      - Editors’ Choice. Science Signaling 9:ec77, 2016.

Lee KE, Simon MC:  SnapShot: Hypoxia-Inducible Factors. Cell 163:1288-1288.e1, 2015.

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR:  Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest 123:4681-4694, 2013.

Pylayeva-Gupta Y, Lee KE, Bar-Sagi D:  Microdissection and culture of murine pancreatic ductal epithelial cells. Methods Mol Biol 980:267-279, 2013.

Lee KE, Simon MC:  From Stem Cells to Cancer Stem Cells: HIF Takes the Stage. Curr Opin Cell Biol 24:232-235, 2012.

Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D:  Oncogenic Kras-induced GM-CSF production supports the development of pancreatic neoplasia. Cancer Cell 21:836-847, 2012.

Mallen-St.Clair J, Soydaner-Azeloglu R, Lee KE, Taylor LJ, Livanos A, Pylayeva-Gupta Y, Miller G, Margueron R, Reinberg D, Bar-Sagi D:  EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev 26:439-444, 2012.

Lee KE, Bar-Sagi D:  Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell 18:448-458, 2010.
      - Research Highlight In Brief. Nature Reviews Cancer 11:5, 2011.

Agbunag C, Lee KE, Buontempo S, Bar-Sagi D: Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods Enzymol 407:703-710, 2006.