Matthew Brody, Ph.D.

Assistant Professor of Pharmacology
Assistant Professor of Internal Medicine

Office: 1220B MSRB III

Lab: 1240 MSRB III

Office: 734-763-3255 Lab: 734-647-8807

Areas of Interest

Molecular Cardiovascular Biology

Honors & Awards

  • 2018 American Heart Association Louis N. and Arnold M. Katz Basic Research Prize for Early Career Investigators winner
  • 2018-2022 National Institutes of Health K99 Pathway to Independence Award
  • 2016 Postdoctoral Travel Award, American Society of Biochemistry & Molecular Biology, Experimental Biology 2016 Meeting
  • 2015 New Investigator Travel Award, American Heart Association, Basic Cardiovascular Sciences Scientific Sessions 2015 Meeting
  • 2014-2017 National Institutes of Health F32 Ruth L. Kirschstein National Research Service Award
  • 2013 Graduate Trainee, National Institute of Environmental Health Sciences, Molecular & Environmental Toxicology Training Grant (T32 ES007015)
  • 2012 University of Wisconsin-Madison Vilas Travel Fellowship
  • 2011-2013 American Heart Association Predoctoral Fellowship
  • 2007 Highest Honors in Environmental Toxicology, University of California Davis
  • 2007 Environmental Toxicology Departmental Citation
  • 2005-2006 University of California Davis Annual Fund Scholarship
  • 2003-2007 Golden Key National Honor Society
  • 2003-2006 University of California Davis Dean’s Honor List

Credentials

Education

PhD, Molecular and Environmental Toxicology, University of Wisconsin-Madison, WI, 2013

BS with Highest Honors, University of California Davis, Davis, CA, 2007

Post-Doctoral Training

Postdoctoral Fellow, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2013-2018

Published Articles or Reviews

  • Brody MJ,Vanhoutte D, Bakshi CV, Liu R, Correll RN, Sargent MA, and Molkentin JD. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. J Biol Chem, 294, 2019.
  • Brody MJ, Vanhoutte D, Schips TG, Boyer JG, Bakshi CV, Sargent MA, York AJ, and Molkentin JD. Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Mol Cell Biol, 38 (14), 2018. ~selected for the cover photo and chosen as a Spotlight article by the Editor
  • Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisicak O, and Molkentin JD. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. ELife, 6:30543, 2017.
  • Brody MJ, Schips TG, Vanhoutte D, Kanisicak O, Karch J, Maliken BD, Blair NS, Sargent MA, Prasad V and Molkentin JD. Dissection of Thrombospondin-4 domains involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Mol Cell Biol, 36(1):2-12, 2016.
  • Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Rabinowitz JE, Volk T, McNally EM, and Molkentin JD. Thrombospondin expression in myofibers stabilizes muscle membranes. ELife, 5:17589, 2016.
  • Brody MJ and Lee Y. The role of Leucine-rich repeat containing protein 10 (LRRC10) in dilated cardiomyopathy. Front Physiol, 7(337): 1-6, 2016
  • Brody MJ, Feng L, Grimes AC, Hacker TA, Olson TM, Kamp TJ, Balijepalli RC, Lee Y. LRRC10 is required to maintain cardiac function in response to pressure overload. Am J Physiol Heart Circ Physiol, 310(2):H269-78, 2016.
  • Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ,Tallquist MD, Molkentin JD. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun, 7:12260, 2016.
  • Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PLoS One, 10(6):e0130520, 2015.
  • Brody MJ, Cho E, Mysliwiec MR, Kim T, Carlson CD, Lee K, and Lee Y. Lrrc10 is a novel cardiacspecific target gene of Nkx2-5 and GATA4. J Mol Cell Cardiol, 62: 237-246, 2013.
  • Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, and Lee Y. Ablation of the cardiac-specific gene Leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One, 7(12):e51621, 2012.
  • Rufer ES, Hacker TA, Flentke GR, Drake VJ, Brody MJ, Lough J, Smith SM. Altered cardiac function and ventricular septal defect in avian embryos exposed to low-dose trichloroethylene. Toxicol Sci,113(2):444-52, 2010.

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