Pharmacology Publications on PubMed During COVID Shutdown

Novel Immunotherapeutic Approaches in Head and Neck Cancer.  

Heft Neal ME, Haring CT, Mann JE, Brenner JC, Spector ME, Swiecicki PL.J Cancer Metastasis Treat. 2019;5:76. doi: 10.20517/2394-4722.2019.32. Epub 2019 Nov 22.
PMID: 32661502 Free PMC article.

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function. 

Bennett JA, Mastrangelo MA, Ture SK, Smith CO, Loelius SG, Berg RA, Shi X, Burke RM, Spinelli SL, Cameron SJ, Carey TE, Brookes PS, Gerszten RE, Sabater-Lleal M, de Vries PS, Huffman JE, Smith NL, Morrell CN, Lowenstein CJ.Nat Commun. 2020 Jul 13;11(1):3479. doi: 10.1038/s41467-020-17254-w.
PMID: 32661250

Integrating Optical and Electrochemical Approaches to Assess the Actions of Dynamin at the Fusion Pore.        

Smith KA, Prantzalos ER, Anantharam A.Methods Mol Biol. 2020;2159:163-178. doi: 10.1007/978-1-0716-0676-6_12.
PMID: 32529370

Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis.

Bouza AA, Philippe JM, Edokobi N, Pinsky AM, Offord J, Calhoun JD, Lopez-Florán M, Lopez-Santiago LF, Jenkins PM, Isom LL.J Biol Chem. 2020 Jun 5:jbc.RA120.013978. doi: 10.1074/jbc.RA120.013978. Online ahead of print.
PMID: 32503841

Sex Differences in 11-Oxygenated Androgen Patterns Across Adulthood.     

Davio A, Woolcock H, Nanba AT, Rege J, O'Day P, Ren J, Zhao L, Ebina H, Auchus R, Rainey WE, Turcu AF.J Clin Endocrinol Metab. 2020 Aug 1;105(8):dgaa343. doi: 10.1210/clinem/dgaa343.
PMID: 32498089 Free PMC article.

Sex Differences in Biophysical Signatures across Molecularly Defined Medial Amygdala Neuronal Subpopulations.     

Matos HY, Hernandez-Pineda D, Charpentier CM, Rusk A, Corbin JG, Jones KS.eNeuro. 2020 Jul 2;7(4):ENEURO.0035-20.2020. doi: 10.1523/ENEURO.0035-20.2020. Print 2020 Jul/Aug.
PMID: 32493755 Free PMC article.

Androgen excess and diagnostic steroid biomarkers for nonclassic 21-hydroxylase deficiency without cosyntropin stimulation.    

Turcu AF, El-Maouche D, Zhao L, Nanba AT, Gaynor A, Veeraraghavan P, Auchus RJ, Merke DP.Eur J Endocrinol. 2020 Jul;183(1):63-71. doi: 10.1530/EJE-20-0129.
PMID: 32487778

Ketamine's dose related multiple mechanisms of actions: Dissociative anesthetic to rapid antidepressant.   

Lavender E, Hirasawa-Fujita M, Domino EF.Behav Brain Res. 2020 Jul 15;390:112631. doi: 10.1016/j.bbr.2020.112631. Epub 2020 May 8.
PMID: 32437885 Review.

A signature that may be predictive of early vs. late recurrence after radiation treatment (RT) for breast cancer that may inform the biology of early, aggressive recurrences.  

Speers C, Chang SL, Pesch A, Ritter C, Olsen E, Chandler B, Moubadder L, Liu M, Cameron M, Michmerhuizen A, Wilder-Romans K, Zhao SG, Nyati S, Bartelink H, Feng FY, Pierce LJ.Int J Radiat Oncol Biol Phys. 2020 May 17:S0360-3016(20)31139-1. doi: 10.1016/j.ijrobp.2020.05.015. Online ahead of print.
PMID: 32434041

Sex and region-specific effects of high fat diet on PNNs in obesity susceptible rats.

Dingess PM, Zhang Z, Sorg BA, Ferrario CR, Brown TE.Physiol Behav. 2020 Aug 1;222:112963. doi: 10.1016/j.physbeh.2020.112963. Epub 2020 May 15.
PMID: 32416158

In vitro pharmacology of fentanyl analogs at the human mu opioid receptor and their spectroscopic analysis.

Hassanien SH, Bassman JR, Perrien Naccarato CM, Twarozynski JJ, Traynor JR, Iula DM, Anand JP.Drug Test Anal. 2020 May 15. doi: 10.1002/dta.2822. Online ahead of print.
PMID: 32415719

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.         

Perry SC, Kalyanaraman C, Tourdot BE, Conrad WS, Akinkugbe O, Freedman JC, Holinstat M, Jacobson MP, Holman TR.J Lipid Res. 2020 Jul;61(7):1087-1103. doi: 10.1194/jlr.RA120000777. Epub 2020 May 13.
PMID: 32404334

Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition.        

Fisher IJ, Jenkins ML, Tall GG, Burke JE, Smrcka AV.Structure. 2020 Jul 7;28(7):810-819.e5. doi: 10.1016/j.str.2020.04.012. Epub 2020 May 12.
PMID: 32402248

Liquid chromatography above 20,000 PSI.

Sorensen MJ, Anderson BG, Kennedy RT.Trends Analyt Chem. 2020 Mar;124:115810. doi: 10.1016/j.trac.2020.115810. Epub 2020 Jan 21.
PMID: 32382203

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.      

Freedman C, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR.Biochemistry. 2020 May 19;59(19):1832-1844. doi: 10.1021/acs.biochem.0c00233. Epub 2020 May 7.
PMID: 32324389

"Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets.

Satin LS, Zhang Q, Rorsman P.Diabetes. 2020 May;69(5):830-836. doi: 10.2337/dbi19-0012.
PMID: 32312899

Novel C-terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self-renewal, and epithelial-mesenchymal transition.    

Subramanian C, Grogan PT, Wang T, Bazzill J, Zuo A, White PT, Kalidindi A, Kuszynski D, Wang G, Blagg BSJ, Cohen MS.Mol Oncol. 2020 Apr 7. doi: 10.1002/1878-0261.12686. Online ahead of print.
PMID: 32255264

The discovery and development of binimetinib for the treatment of melanoma.

Tran B, Cohen MS.Expert Opin Drug Discov. 2020 Apr 4:1-10. doi: 10.1080/17460441.2020.1746265. Online ahead of print.
PMID: 32249628

Hypertension induces glomerulosclerosis in phospholipase C-ε1 deficiency.  

Atchison DK, O'Connor CL, Menon R, Otto EA, Ganesh SK, Wiggins RC, Smrcka AV, Bitzer M.Am J Physiol Renal Physiol. 2020 May 1;318(5):F1177-F1187. doi: 10.1152/ajprenal.00541.2019. Epub 2020 Mar 30.
PMID: 32223311

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.

Steen K, Chen D, Wang F, Majumdar R, Chen S, Kumar S, Lombard DB, Weigert R, Zieman AG, Parent CA, Coulombe PA.Mol Biol Cell. 2020 May 15;31(11):1103-1111. doi: 10.1091/mbc.E19-10-0565. Epub 2020 Mar 26.
PMID: 32213122 Free PMC article

Intermittent access cocaine self-administration produces psychomotor sensitization: effects of withdrawal, sex and cross-sensitization.           

Carr CC, Ferrario CR, Robinson TE.Psychopharmacology (Berl). 2020 Jun;237(6):1795-1812. doi: 10.1007/s00213-020-05500-4. Epub 2020 Mar 24.
PMID: 32206828

11-Oxygenated androgens in health and disease.          

Turcu AF, Rege J, Auchus RJ, Rainey WE.Nat Rev Endocrinol. 2020 May;16(5):284-296. doi: 10.1038/s41574-020-0336-x. Epub 2020 Mar 16.
PMID: 32203405 Review.

ER stress increases store-operated Ca2+ entry (SOCE) and augments basal insulin secretion in pancreatic beta cells.

Zhang IX, Ren J, Vadrevu S, Raghavan M, Satin LS.J Biol Chem. 2020 Apr 24;295(17):5685-5700. doi: 10.1074/jbc.RA120.012721. Epub 2020 Mar 16.
PMID: 32179650

An improved demand curve for analysis of food or drug consumption in behavioral experiments.

Newman M, Ferrario CR. Psychopharmacology (Berl). 2020 Apr;237(4):943-955. doi: 10.1007/s00213-020-05491-2. Epub 2020 Mar 13.
PMID: 32170328 Free PMC article.

Molecularly Engineered Nanobodies for Tunable Pharmacokinetics and Drug Delivery.

Glassman PM, Walsh LR, Villa CH, Marcos-Contreras OA, Hood ED, Muzykantov VR, Greineder CF.Bioconjug Chem. 2020 Apr 15;31(4):1144-1155. doi: 10.1021/acs.bioconjchem.0c00003. Epub 2020 Mar 20.
PMID: 32167754

Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin.

Flak JN, Goforth PB, Dell'Orco J, Sabatini PV, Li C, Bozadjieva N, Sorensen M, Valenta A, Rupp A, Affinati AH, Cras-Méneur C, Ansari A, Sacksner J, Kodur N, Sandoval DA, Kennedy RT, Olson DP, Myers MG Jr.J Clin Invest. 2020 Jun 1;130(6):2943-2952. doi: 10.1172/JCI134135.
PMID: 32134398

Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.

Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G.Cell Rep. 2020 Mar 17;30(11):3699-3709.e6. doi: 10.1016/j.celrep.2020.02.086. Epub 2020 Mar 2.
PMID: 32126208 Free PMC article.

The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.

Denomme N, Lukowski AL, Hull JM, Jameson MB, Bouza AA, Narayan ARH, Isom LL.Neurosci Lett. 2020 Apr 17;724:134853. doi: 10.1016/j.neulet.2020.134853. Epub 2020 Feb 27.
PMID: 32114117

Targeted degradation of activating estrogen receptor α ligand-binding domain mutations in human breast cancer.

Gonzalez TL, Hancock M, Sun S, Gersch CL, Larios JM, David W, Hu J, Hayes DF, Wang S, Rae JM.Breast Cancer Res Treat. 2020 Apr;180(3):611-622. doi: 10.1007/s10549-020-05564-y. Epub 2020 Feb 17.
PMID: 32067153

Effects of dose on acquisition and persistence of a new response for a remifentanil-associated stimulus.

Robertson SH, Jutkiewicz EM.Version 2. Behav Pharmacol. 2020 Apr;31(2&3):207-215. doi: 10.1097/FBP.0000000000000550.
PMID: 32058349 Free PMC article

Abiraterone acetate treatment lowers 11-oxygenated androgens. 

Wright C, O'Day P, Alyamani M, Sharifi N, Auchus RJ.Eur J Endocrinol. 2020 Apr;182(4):413-421. doi: 10.1530/EJE-19-0905.
PMID: 32045360

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils.

Cash JN, Chandan NR, Hsu AY, Sharma PV, Deng Q, Smrcka AV, Tesmer JJG.Mol Pharmacol. 2020 Mar;97(3):226-236. doi: 10.1124/mol.119.117556. Epub 2020 Jan 3.
PMID: 31900312

PLCε1 suppresses tumor growth by regulating murine T cell mobilization.

Strazza M, Adam K, Smrcka AV, Lerrer S, Mor A.Clin Exp Immunol. 2020 Apr;200(1):53-60. doi: 10.1111/cei.13409. Epub 2020 Jan 9.
PMID: 31867717

Comparison of the muscarinic antagonist effects of scopolamine and L-687,306.

Winger G, Jutkiewicz EM, Woods JH.Behav Pharmacol. 2020 Jun;31(4):359-367. doi: 10.1097/FBP.0000000000000537.
PMID: 31922966

Pharmacological Properties of Delta Opioid Receptor-Mediated Behaviors: Agonist Efficacy and Receptor Reserve.

Dripps IJ, Chen R, Shafer AM, Livingston KE, Disney A, Husbands SM, Traynor JR, Rice KC, Jutkiewicz EM.J Pharmacol Exp Ther. 2020 May 28:jpet.119.262717. doi: 10.1124/jpet.119.262717. Online ahead of print.
PMID: 32467352 Free article