Cancer Pharmacology

Research efforts in cancer pharmacology are centered on uncovering the cellular and molecular underpinnings of cancer, and to identify and develop novel anti-cancer targets and therapeutic strategies. Our efforts bridge the fields of molecular carcinogenesis, biochemical pharmacology, radiation biology, and clinical pharmacology. Our research programs are highly collaborative within the Pharmacology Department and with the Rogel Cancer Center, an NCI-designated comprehensive cancer center.


RESEARCH FOCUS: Sarcoma tumor biology.

RESEARCH FOCUS: Bioinformatics, high-throughput siRNA/drug screening and functional genomics approaches to understand cancer biology and discover novel small molecule therapeutics.

RESEARCH FOCUS: Cancer cell biology, signal transduction, responses to DNA replication stress and DNA damaging chemotherapeutic drugs, genome stability and DNA repair.

RESEARCH FOCUS: Signal transduction in the immune system, T cell signaling pathways, immunotherapy strategies, protein regulation, and cancer therapeutics.

RESEARCH FOCUS: Chemical carcinogenesis: metabolic activation and detoxication of carcinogens, mechanisms of carcinogen-activating enzymes, cytochrome P-450 and biological oxidations and peroxidations.

RESEARCH FOCUS: Pancreatic cancer, hypoxia and immune cells.

RESEARCH FOCUS: Signal transduction pathways, inflammation, immune responses, tissue repair, and cancer metastasis.

RESEARCH FOCUS: GPCR trafficking and signaling, opioid, drug addiction.

RESEARCH FOCUS: Predicting response to breast cancer therapies by way of pharmacogenetic, pharmacogenomic, drug metabolism and candidate gene pathway analyses.

RESEARCH FOCUS: Adaptation of state-of-the-art organic chemistry techniques (including SPOS) for radiochemical applications, Microwave mediated radiochemistry, Development of multi-modality biomarkers for PET-MRI.

RESEARCH FOCUS: Drug discovery, molecular pharmacology, assay development, and biomarker validation.

RESEARCH FOCUS: Heterotrimeric G protein Signaling, G protein folding chaperones, Mechanisms of Adhesion GPCR action, Somatic G protein disease mutations, GNAQ/11-driven uveal melanoma, High throughput screening and small molecule probe discovery.