Cardiovascular Pharmacology

The cardiovascular system is remarkably complex, incorporating the heart, kidney, vasculature, and numerous other organs and tissues. Michigan Pharmacology is developing novel therapeutics through interdisciplinary studies that utilize the latest cutting-edge molecular, biochemical, and genetic technologies applied to studies in isolated animal and human cells and intact animal models of disease. This work translates discoveries on the fundamental aspects of human physiology and pathophysiology into real world solutions for modern clinical problems, which may result in novel medicines for the treatment of an array of diseases including thrombosis, heart failure, cardiac arrhythmia, and kidney disease.

RESEARCH FOCUS: Molecular Cardiovascular Biology.

RESEARCH FOCUS: Cardiovascular medicine, molecular basis of diabetes/obesity-induced cardiovascular diseases and stroke.

RESEARCH FOCUS: Platelets, Thrombosis, Hemostasis, Clotting, Lipids, Lipoxygenase, Clinical research, Translational research, 12-LOX.

RESEARCH FOCUS: Mechanisms of epileptic encephalopathy and cardiac arrhythmias linked to mutations in voltage-gated sodium channel genes; mechanisms of sudden unexpected death in epilepsy (SUDEP); ion channel structure and function; transgenic mouse models of neurological and cardiac disease; patient-derived induced pluripotent stem cell neurons and cardiac myocytes.

RESEARCH FOCUS: Voltage-gated potassium channel, hERG, cardiac physiology and pathophysiology.

RESEARCH FOCUS: GPCR trafficking and signaling; opioid, drug addiction.

RESEARCH FOCUS: Lysosomal storage diseases and the biochemistry, cellular biology and pharmacology of sphingolipids.

RESEARCH FOCUS: G proteins; G protein coupled-receptors; Cell Signaling Pathways; Drug Discovery; Cardiac Hypertrophy; Innate Immune Cell Regulation; Phosphatidylinositol, Calcium, and Protein kinase Signaling.

RESEARCH FOCUS: Cardiovascular toxicology, developmental origins of health and disease, sex differences, epigenetics

RESEARCH FOCUS: Heterotrimeric G protein Signaling, G protein folding chaperones, Mechanisms of Adhesion GPCR action, Somatic G protein disease mutations, GNAQ/11-driven uveal melanoma, High throughput screening and small molecule probe discovery.

RESEARCH FOCUS: Drug metabolism and discovery, cytochrome P450 structure and function, Chaperone Hsp 70.

RESEARCH FOCUS: Electrophysiology, cardiac function, cardiovascular physiology.