G-Protein Signaling

G protein coupled receptors (GPCRs) form a large family of cell surface receptors responsible for triggering cellular responses to a variety of extracellular stimuli including drugs such as opiates, and hormones such as adrenaline, serotonin, or acetylcholine. This family of receptors is an important target for pharmaceuticals. Importantly, defects in GPCR systems are responsible for a number of human diseases. At Michigan Pharmacology we study mechanisms of GPCR, G protein, and second messenger signaling at the molecular level and then translate these molecular principles into understanding how G proteins regulate cellular and organismal functions.

Faculty

Michael Holinstat, Associate Professor

RESEARCH FOCUS: Platelets, Thrombosis, Hemostasis, Clotting, Lipids, Lipoxygenase, Clinical research, Translational research, 12-LOX

Jorge A. Iniguez-Lluhi, Associate Professor

RESEARCH FOCUS: Protein Regulation by SUMO modification - Basic Mechanisms of Transcriptional Regulation - Mechanism of Action and Pathobiology of Steroid Hormone Receptors - Clinical Glucocorticoid Resistance - Multiscale Modeling.

Manojkumar Puthenveedu, Associate Professor

RESEARCH FOCUS: GPCR trafficking and signaling, opioid, drug addiction.

Alan Smrcka, Professor

RESEARCH FOCUS: G proteins; G protein coupled-receptors; Cell Signaling Pathways; Drug Discovery; Cardiac Hypertrophy; Innate Immune Cell Regulation; Phosphatidylinositol, Calcium, and Protein kinase Signaling.

Greg Tall, Associate Professor

RESEARCH FOCUS: Heterotrimeric G protein Signaling, G protein folding chaperones, Mechanisms of Adhesion GPCR action, Somatic G protein disease mutations, GNAQ/11-driven uveal melanoma, High throughput screening and small molecule probe discovery.

John Traynor, Professor

RESEARCH FOCUS: Mechanisms of action of addictive drugs. To provide medications for pain relief and the treatment of addictions.