Ion Channels are proteins that regulate the electrical activity of cells. They are essential for electrical signal transduction, including cardiac contraction and neurotransmission. Defects in ion channel function result in paroxysmal diseases like cardiac arrhythmias, epilepsy, and neuropathic pain. Because of this, ion channels are very important drug targets. At Michigan Pharmacology our research ranges from understanding the fundamental mechanisms of ion channel function to their disregulation in human disease.
RESEARCH FOCUS: sympathetic stress response, exocytosis, synaptic transmission, neuropeptide sorting and secretion, vesicle biogenesis, TIRF microscopy, super-resolution microscopy, electrophysiology, endocytosis.
RESEARCH FOCUS: Striaum; glutamatergic plasticity; receptor trafficking; behavioral pharmacology; addiction; obesity.
RESEARCH FOCUS: Mechanism of action of amphetamine at the dopamine transporter; substrate and protein kinase effects on transporter trafficking; drugs to stop effects of amphetamine.
RESEARCH FOCUS: Mechanisms of epileptic encephalopathy and cardiac arrhythmias linked to mutations in voltage-gated sodium channel genes; mechanisms of sudden unexpected death in epilepsy (SUDEP); ion channel structure and function; transgenic mouse models of neurological and cardiac disease; patient-derived induced pluripotent stem cell neurons and cardiac myocytes.
RESEARCH FOCUS: Cellular and molecular neuroscience, Neuropsychiatric disease mechanisms, Bipolar disorder, Protein trafficking, Palmitoylation, Epithelial cell biology,Membrane structure, Mouse models, Electrophysiology.
RESEARCH FOCUS: voltage-gated potassium channel, hERG, cardiac physiology and pathophysiology.
RESEARCH FOCUS: Schizophrenia; Depression, Glutamate signaling, GABAergic interneurons, Fast-Spiking Interneurons, Patch-Clamp Electrophysiology, Behavior, NMDA receptors.
RESEARCH FOCUS: Cellular and molecular basis of Type 2 diabetes; ER stress and protein folding diseases; metabolic regulation of ion channel activity; optical methods; drug discovery in diabetes; synaptic transmission and metabolic health of neurons after brain trauma, models of cell function and signaling.