Cancer Pharmacology focuses on developing experimental approaches to the clinical treatment of cancer through research that bridges the fields of molecular carcinogenesis, biochemical pharmacology, radiation biology, and clinical pharmacology. Cancer Pharmacology is part of the University of Michigan Rogel Cancer Center, which is one of 40 National Cancer Institute-designated centers for research on and treatment of cancer.
RESEARCH FOCUS: Cancer cell biology, signal transduction, responses to DNA replication stress and DNA damaging chemotherapeutic drugs, genome stability and DNA repair.
RESEARCH FOCUS: Hypoxia, B Lymphocytes, Fibrosis, Tumorigenesis, Pancreatic Diseases.
RESEARCH FOCUS: Use of cell cycle checkpoint inhibitors to improve the therapeutic effectiveness of chemotherapy and radiation in cancer treatment.
RESEARCH FOCUS: Cancer Biology, Cell Biology, Immunology.
RESEARCH FOCUS: G proteins; G protein coupled-receptors; Cell Signaling Pathways; Drug Discovery; Cardiac Hypertrophy; Innate Immune Cell Regulation; Phosphatidylinositol, Calcium, and Protein kinase Signaling.
Greg Tall, Associate Professor
RESEARCH FOCUS: Heterotrimeric G protein Signaling, G protein folding chaperones, Mechanisms of Adhesion GPCR action, Somatic G protein disease mutations, GNAQ/11-driven uveal melanoma, High throughput screening and small molecule probe discovery.
Richard Auchus (Internal Medicine), Professor
RESEARCH FOCUS: steroidogenesis; endocrinology; enzymology; cytochrome P450.
Thomas Carey (Otolaryngology), Professor
RESEARCH FOCUS: Human Papillomavirus (HPV), Head and neck Cancer, mechanisms and predictive markers for response to therapy, Oral HPV infection and risk of oropharyngeal cancer.
Eugene Chen, Professor
RESEARCH FOCUS: cardiovascular medicine, molecular basis of diabetes/obesity-induced cardiovascular diseases and stroke.
Mark Cohen (Surgery), Associate Professor
RESEARCH FOCUS: Development of novel drugs including naturally derived withanolides, novel HSP90 inhibitors and nanoparticle drug delivery systems for improved treatment of cancers, bone and wound healing, sepsis, and endocrine diseases.
Judith Leopold (Cancer Center, Radiology), Research Professor
RESEARCH FOCUS: Oncogene signaling, kinase inhibitor drug discovery, colorectal and pancreatic cancer.
James Rae, Associate Professor
RESEARCH FOCUS: Predicting response to breast cancer therapies by way of pharmacogenetic, pharmacogenomic, drug metabolism and candidate gene pathway analyses.
Emily Scott, Professor
RESEARCH FOCUS: Structure/function of cytochrome P450 enzymes; drug metabolism; drug design.
Shaomeng Wang (Medicinal Chemistry, Internal Medicine), Professor
RESEARCH FOCUS: Small-molecule drug design, synthesis, discovery, evaluation and development; new computational methods for drug design.