Cancer Pharmacology

Cancer Pharmacology focuses on developing experimental approaches to the clinical treatment of cancer through research that bridges the fields of molecular carcinogenesis, biochemical pharmacology, radiation biology, and clinical pharmacology. Cancer Pharmacology is part of the University of Michigan Comprehensive Cancer Center, which is one of 40 National Cancer Institute-designated centers for research on and treatment of cancer.

Faculty

Christine Canman, Association Professor

RESEARCH FOCUS: Cancer cell biology, signal transduction, responses to DNA replication stress and DNA damaging chemotherapeutic drugs, genome stability and DNA repair.

Kyoung Eun Lee, Assistant Professor

RESEARCH FOCUS: Hypoxia, B Lymphocytes, Fibrosis, Tumorigenesis, Pancreatic Diseases.

 

Jonathan Maybaum, Professor

RESEARCH FOCUS: Use of cell cycle checkpoint inhibitors to improve the therapeutic effectiveness of chemotherapy and radiation in cancer treatment.

Carole Parent, Professor

RESEARCH FOCUS: Cancer Biology, Cell Biology, Immunology.

Donna Shewach, Professor

RESEARCH FOCUS: Improving cancer chemotherapy through novel mechanisms and gene therapy strategies.

Alan Smrcka, Professor

RESEARCH FOCUS: G proteins; G protein coupled-receptors; Cell Signaling Pathways; Drug Discovery; Cardiac Hypertrophy; Innate Immune Cell Regulation; Phosphatidylinositol, Calcium, and Protein kinase Signaling.

Greg Tall, Associate Professor

RESEARCH FOCUS: Heterotrimeric G protein Signaling, G protein folding chaperones, Mechanisms of Adhesion GPCR action, Somatic G protein disease mutations, GNAQ/11-driven uveal melanoma, High throughput screening and small molecule probe discovery.

Joint/Adjunct Faculty

Richard Auchus (Internal Medicine), Professor

RESEARCH FOCUS: steroidogenesis; endocrinology; enzymology; cytochrome P450.

Thomas Carey (Otolaryngology), Professor

RESEARCH FOCUS: Human Papillomavirus (HPV), Head and neck Cancer, mechanisms and predictive markers for response to therapy, Oral HPV infection and risk of oropharyngeal cancer.

Eugene Chen, Professor

RESEARCH FOCUS: cardiovascular medicine, molecular basis of diabetes/obesity-induced cardiovascular diseases and stroke.

Mark Cohen (Surgery), Associate Professor

RESEARCH FOCUS: Development of novel drugs including naturally derived withanolides, novel HSP90 inhibitors and nanoparticle drug delivery systems for improved treatment of cancers, bone and wound healing, sepsis, and endocrine diseases.

Judith Leopold (Cancer Center, Radiology), Research Professor

RESEARCH FOCUS: Oncogene signaling, kinase inhibitor drug discovery, colorectal and pancreatic cancer.

James Rae, Associate Professor

RESEARCH FOCUS: Predicting response to breast cancer therapies by way of pharmacogenetic, pharmacogenomic, drug metabolism and candidate gene pathway analyses.

Emily Scott, Professor

RESEARCH FOCUS: Structure/function of cytochrome P450 enzymes; drug metabolism; drug design.

Shaomeng Wang (Medicinal Chemistry, Internal Medicine), Professor

RESEARCH FOCUS: Small-molecule drug design, synthesis, discovery, evaluation and development; new computational methods for drug design.