Precision Medicine

The goal of Precision Medicine in Pharmacology is to personalize patient care such that they will respond most effectively to a given treatment.  To achieve this, we must understand in detail how different patients and populations respond to different drugs and then correlate this with biomarkers of disease.  At Michigan Pharmacology several laboratories are studying patient samples, including patient derived induced pluripotent stem cells, with various pathologies to understand the basis for unique responses to different therapies.

Faculty

Michael Holinstat, Associate Professor

RESEARCH FOCUS: Platelets, Thrombosis, Hemostasis, Clotting, Lipids, Lipoxygenase, Clinical research, Translational research, 12-LOX
Holinstat lab

Lori Isom, Professor

RESEARCH FOCUS: Mechanisms of epileptic encephalopathy and cardiac arrhythmias linked to mutations in voltage-gated sodium channel genes; mechanisms of sudden unexpected death in epilepsy (SUDEP); ion channel structure and function; transgenic mouse models of neurological and cardiac disease; patient-derived induced pluripotent stem cell neurons and cardiac myocytes.
Isom Lab

Dave Jones, Assistant Professor

RESEARCH FOCUS:  voltage-gated potassium channel, hERG, cardiac physiology and pathophysiology.

Yoichi Osawa, Professor

RESEARCH FOCUS: Hsp90 and Hsp70 chaperones, ubiquitination, protein quality control, nitric oxide synthases, steroid receptors, cytochrome P450.
Osawa Lab

Joint/Adjunct Faculty

James Rae, Professor

RESEARCH FOCUS: Predicting response to breast cancer therapies by way of pharmacogenetic, pharmacogenomic, drug metabolism and candidate gene pathway analyses.
Ray Lab

 

 

Emily Scott, Professor

RESEARCH FOCUS: Structure/function of cytochrome P450 enzymes; drug metabolism; drug design.
Scott Lab