Translational Pharmacology

Translational Pharmacology is the science of transitioning (or translating) knowledge gained at the bench in order to advance the innovation into practice in a clinical setting. The Department of Pharmacology at the University of Michigan is a leader in this area, translating innovations, new therapies, as well as novel diagnostics to clinical practice. The strength of our translational pharmacology group spans many disease areas including epilepsy, thrombosis, cardiovascular medicine, and cancer.

Faculty

RESEARCH FOCUS: Sarcoma tumor biology.

RESEARCH FOCUS: Bioinformatics, high-throughput siRNA/drug screening and functional genomics approaches to understand cancer biology and discover novel small molecule therapeutics.

RESEARCH FOCUS: Molecular Cardiovascular Biology.

RESEARCH FOCUS: Cardiovascular medicine, molecular basis of diabetes/obesity-induced cardiovascular diseases and stroke.

RESEARCH FOCUS: Platelets, Thrombosis, Hemostasis, Clotting, Lipids, Lipoxygenase, Clinical research, Translational research, 12-LOX.

RESEARCH FOCUS: Mechanisms of epileptic encephalopathy and cardiac arrhythmias linked to mutations in voltage-gated sodium channel genes; mechanisms of sudden unexpected death in epilepsy (SUDEP); ion channel structure and function; transgenic mouse models of neurological and cardiac disease; patient-derived induced pluripotent stem cell neurons and cardiac myocytes.

RESEARCH FOCUS: Cellular and molecular neuroscience, Neuropsychiatric disease mechanisms, Bipolar disorder, Protein trafficking, Palmitoylation, Epithelial cell biology,Membrane structure, Mouse models, Electrophysiology.

RESEARCH FOCUS: Voltage-gated potassium channel, hERG, cardiac physiology and pathophysiology.

RESEARCH FOCUS: Hsp90 and Hsp70 chaperones, ubiquitination, protein quality control, nitric oxide synthases, steroid receptors, cytochrome P450.

RESEARCH FOCUS: GPCR trafficking and signaling, opioid, drug addiction.

RESEARCH FOCUS: Predicting response to breast cancer therapies by way of pharmacogenetic, pharmacogenomic, drug metabolism and candidate gene pathway analyses.

RESEARCH FOCUS: Adaptation of state-of-the-art organic chemistry techniques (including SPOS) for radiochemical applications, Microwave mediated radiochemistry, Development of multi-modality biomarkers for PET-MRI.

RESEARCH FOCUS: Drug discovery, molecular pharmacology, assay development, and biomarker validation.

RESEARCH FOCUS: Lysosomal storage diseases and the biochemistry, cellular biology and pharmacology of sphingolipids.

RESEARCH FOCUS: Heterotrimeric G protein Signaling, G protein folding chaperones, Mechanisms of Adhesion GPCR action, Somatic G protein disease mutations, GNAQ/11-driven uveal melanoma, High throughput screening and small molecule probe discovery.

RESEARCH FOCUS: Neurotoxicology, neuropharmacology/neurophysiology and neurological disorders.

RESEARCH FOCUS: Drug metabolism and discovery, cytochrome P450 structure and function, Chaperone Hsp 70.