Professor of Molecular and Integrative Physiology
Professor of Int Med
Professor of Pharmacology
Adj Professor of Molec, Cell & Dev Biology
Col of Lit, Science, and the Arts
[email protected]
Available to mentor
Richard M Mortensen
Professor
We have been investigation the role of obesity, diabetes and metabolite function in cardiovascular disease. Focus has been on the function of PPAR-gamma, mineralocorticoid receptor, inflammation, and the metabolite, itaconate.
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberCaswell Diabetes Institute
Metabolism and cardiovascular disease
Inflammation and Mineralocorticoid Receptor
PPAR-gamma function
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Song J, Zhang Y, Frieler RA, Andren A, Wood S, Tyrrell DJ, Sajjakulnukit P, Deng JC, Lyssiotis CA, Mortensen RM, Salmon M, Goldstein DR. J Clin Invest, 2023 Dec 12; 134 (3):Journal ArticleItaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice.
DOI:10.1172/JCI173034 PMID: 38085578 -
Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, Abou El Ela A, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Mortensen RM, Tang PC. Sci Transl Med, 2023 Feb 8; 15 (682): eade3782Journal ArticleMetabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.
DOI:10.1126/scitranslmed.ade3782 PMID: 36753565 -
Frieler RA, Vigil TM, Song J, Leung C, Goldstein DR, Lumeng CN, Mortensen RM. Obesity (Silver Spring), 2022 Sep; 30 (9): 1818 - 1830.Journal ArticleAconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice.
DOI:10.1002/oby.23509 PMID: 35927796 -
Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T. Circ Res, 2022 Jan 21; 130 (2): 234 - 248.Journal ArticleNRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
DOI:10.1161/CIRCRESAHA.121.318898 PMID: 34875852 -
Vigil TM, Frieler RA, Kilpatrick KL, Wang MM, Mortensen RM. Exp Neurol, 2022 Jan; 347: 113902Journal ArticleAconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice.
DOI:10.1016/j.expneurol.2021.113902 PMID: 34699789 -
Frieler RA, Vigil TM, Song J, Leung C, Lumeng CN, Mortensen RM. Obesity (Silver Spring), 2021 Nov; 29 (11): 1868 - 1881.Journal ArticleHigh-fat and high-sodium diet induces metabolic dysfunction in the absence of obesity.
DOI:10.1002/oby.23264 PMID: 34549547 -
Lei I, Huang W, Ward PA, Pober JS, Tellides G, Ailawadi G, Pagani FD, Landstrom AP, Wang Z, Mortensen RM, Cascalho M, Platt J, Eugene Chen Y, Lam HYK, Tang PC. Physiol Rep, 2021 Sep; 9 (17): e15004Journal ArticleDifferential inflammatory responses of the native left and right ventricle associated with donor heart preservation.
DOI:10.14814/phy2.15004 PMID: 34435466 -
Song J, Frieler RA, Vigil TM, Ma J, Brombacher F, Goonewardena SN, Goldstein DR, Mortensen RM. J Am Heart Assoc, 2021 Jul 6; 10 (13): e017329Journal ArticleInactivation of Interleukin-4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt-Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling.
DOI:10.1161/JAHA.120.017329 PMID: 34132103