Available to mentor
Robert Kennedy is a Professor of Chemistry and Pharmacology. His research interests are in bioanalytical chemistry with an emphasis on microfluidics, mass spectrometry, chromatography, and electrophoresis. He develops these methods to study neurotransmitter dynamics in vivo, hormone secretion, and for high-throughput experimentation.
My Background
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PhDUniversity of North Carolina-Chapel Hill, United States, 1988
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Center MemberCaswell Diabetes Institute
We develop and apply bioanalytical methods for studying hormone and neurtransmitter secretion. We develop microfluidic chips to culture cells and integrate methods to measure releasate. We also coupling sampling probes to analytical methods for in vivo brain chemical measurements. We develop metabolomics methods for studying biological systems. We have focused LC-MS/MS, capillary electrophoresis, and sensors for analysis. We have applied to study of islets of Langerhans and various rodent models in the brain.
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Makey DM, Diehl RC, Xin Y, Murray BE, Stoll DR, Ruotolo BT, Grinias JP, Narayan ARH, Lopez-Carillo V, Stark M, Johnen P, Kennedy RT. Anal Chem, 2023 Nov 21; 95 (46): 17028 - 17036.Journal ArticleHigh-Throughput Liquid Chromatographic Analysis Using a Segmented Flow Injector with a 1 s Cycle Time.
DOI:10.1021/acs.analchem.3c03719 PMID: 37943345 -
Jones JD, Franco MK, Tardu M, Smith TJ, Snyder LR, Eyler DE, Polikanov Y, Kennedy RT, Niederer RO, Koutmou KS. 2023 Nov 12;PreprintConserved 5-methyluridine tRNA modification modulates ribosome translocation.
DOI:10.1101/2023.11.12.566704 PMID: 37986750 -
Payne EM, Murray BE, Penabad LI, Abbate E, Kennedy RT. Anal Chem, 2023 Oct 24; 95 (42): 15716 - 15724.Journal ArticleMass-Activated Droplet Sorting for the Selection of Lysine-Producing Escherichia coli.
DOI:10.1021/acs.analchem.3c03080 PMID: 37820298 -
Lenhart AE, Kennedy RT. ACS Meas Sci Au, 2023 Oct 18; 3 (5): 380 - 389.Journal ArticleEvaluation of Surface Treatments of PDMS Microfluidic Devices for Improving Small-Molecule Recovery with Application to Monitoring Metabolites Secreted from Islets of Langerhans.
DOI:10.1021/acsmeasuresciau.3c00025 PMID: 37868359 -
Murray BE, Penabad LI, Kennedy RT. Curr Opin Biotechnol, 2023 Aug; 82: 102962Journal ArticleAdvances in coupling droplet microfluidics to mass spectrometry.
DOI:10.1016/j.copbio.2023.102962 PMID: 37336080 -
Jones JD, Simcox KM, Kennedy RT, Koutmou KS. RNA, 2023 Aug; 29 (8): 1201 - 1214.Journal ArticleDirect sequencing of total Saccharomyces cerevisiae tRNAs by LC-MS/MS.
DOI:10.1261/rna.079656.123 PMID: 37169396 -
Sun AC, Steyer DJ, Robinson RI, Ginsburg-Moraff C, Plummer S, Gao J, Tucker JW, Alpers D, Stephenson CRJ, Kennedy RT. Angew Chem Int Ed Engl, 2023 Jul 10; 62 (28): e202301664Journal ArticleHigh-Throughput Optimization of Photochemical Reactions using Segmented-Flow Nanoelectrospray-Ionization Mass Spectrometry.
DOI:10.1002/anie.202301664 PMID: 36940229 -
Sun AC, Steyer DJ, Robinson RI, Ginsburg‐Moraff C, Plummer S, Gao J, Tucker JW, Alpers D, Stephenson CRJ, Kennedy RT. Angewandte Chemie, 2023 Jul 10; 135 (28):Journal ArticleHigh‐Throughput Optimization of Photochemical Reactions using Segmented‐Flow Nanoelectrospray‐Ionization Mass Spectrometry**
DOI:10.1002/ange.202301664