Robert T Kennedy
Hobart H Willard Distinguished University Professor of Chemistry
Professor of Chemistry, College of Literature, Science, and the Arts
Professor of Pharmacology
Professor of Macromolecular Science and Engineering
[email protected]

Available to mentor

Robert T Kennedy
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Robert Kennedy is a Professor of Chemistry and Pharmacology. His research interests are in bioanalytical chemistry with an emphasis on microfluidics, mass spectrometry, chromatography, and electrophoresis. He develops these methods to study neurotransmitter dynamics in vivo, hormone secretion, and for high-throughput experimentation.

    Links
    • My Background
    Qualifications
    • PhD
      University of North Carolina-Chapel Hill, United States, 1988
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    We develop and apply bioanalytical methods for studying hormone and neurtransmitter secretion. We develop microfluidic chips to culture cells and integrate methods to measure releasate. We also coupling sampling probes to analytical methods for in vivo brain chemical measurements. We develop metabolomics methods for studying biological systems. We have focused LC-MS/MS, capillary electrophoresis, and sensors for analysis. We have applied to study of islets of Langerhans and various rodent models in the brain.

    Recent Publications See All Publications
    • Journal Article
      High-Throughput Liquid Chromatographic Analysis Using a Segmented Flow Injector with a 1 s Cycle Time.
      Makey DM, Diehl RC, Xin Y, Murray BE, Stoll DR, Ruotolo BT, Grinias JP, Narayan ARH, Lopez-Carillo V, Stark M, Johnen P, Kennedy RT. Anal Chem, 2023 Nov 21; 95 (46): 17028 - 17036. DOI:10.1021/acs.analchem.3c03719
      PMID: 37943345
    • Preprint
      Conserved 5-methyluridine tRNA modification modulates ribosome translocation.
      Jones JD, Franco MK, Tardu M, Smith TJ, Snyder LR, Eyler DE, Polikanov Y, Kennedy RT, Niederer RO, Koutmou KS. 2023 Nov 12; DOI:10.1101/2023.11.12.566704
      PMID: 37986750
    • Journal Article
      Mass-Activated Droplet Sorting for the Selection of Lysine-Producing Escherichia coli.
      Payne EM, Murray BE, Penabad LI, Abbate E, Kennedy RT. Anal Chem, 2023 Oct 24; 95 (42): 15716 - 15724. DOI:10.1021/acs.analchem.3c03080
      PMID: 37820298
    • Journal Article
      Evaluation of Surface Treatments of PDMS Microfluidic Devices for Improving Small-Molecule Recovery with Application to Monitoring Metabolites Secreted from Islets of Langerhans.
      Lenhart AE, Kennedy RT. ACS Meas Sci Au, 2023 Oct 18; 3 (5): 380 - 389. DOI:10.1021/acsmeasuresciau.3c00025
      PMID: 37868359
    • Journal Article
      Advances in coupling droplet microfluidics to mass spectrometry.
      Murray BE, Penabad LI, Kennedy RT. Curr Opin Biotechnol, 2023 Aug; 82: 102962 DOI:10.1016/j.copbio.2023.102962
      PMID: 37336080
    • Journal Article
      Direct sequencing of total Saccharomyces cerevisiae tRNAs by LC-MS/MS.
      Jones JD, Simcox KM, Kennedy RT, Koutmou KS. RNA, 2023 Aug; 29 (8): 1201 - 1214. DOI:10.1261/rna.079656.123
      PMID: 37169396
    • Journal Article
      High-Throughput Optimization of Photochemical Reactions using Segmented-Flow Nanoelectrospray-Ionization Mass Spectrometry.
      Sun AC, Steyer DJ, Robinson RI, Ginsburg-Moraff C, Plummer S, Gao J, Tucker JW, Alpers D, Stephenson CRJ, Kennedy RT. Angew Chem Int Ed Engl, 2023 Jul 10; 62 (28): e202301664 DOI:10.1002/anie.202301664
      PMID: 36940229
    • Journal Article
      High‐Throughput Optimization of Photochemical Reactions using Segmented‐Flow Nanoelectrospray‐Ionization Mass Spectrometry**
      Sun AC, Steyer DJ, Robinson RI, Ginsburg‐Moraff C, Plummer S, Gao J, Tucker JW, Alpers D, Stephenson CRJ, Kennedy RT. Angewandte Chemie, 2023 Jul 10; 135 (28): DOI:10.1002/ange.202301664