Shoji Maeda, Ph.D.

Assistant Professor

1301B MSRB III

Areas of Interest

GPCR and downstream signaling cascade, Muscarinic acetylcholine receptors (mAChRs), Three-finger toxins, Antibody/Nanobody development, Protein Engineering

Honors & Awards

  • Roche Postdoc Fellowship, 2010 - 2014 (RPF-112, Mentor: Roger Dawson, Michael Hennig)
  • EMBO Long Term Fellowship, 2011 – 2013 (EMBO ALTF 1667-2010)
  • Young scientist award, 2009 (The 47th annual meeting of the Biophysical Society of Japan)
  • Inoue Research Aid for Young Scientists, 2009 (Inoue Foundation for Science)
  • Research Fellowship for Young Scientist, 2003 – 2006 (DC1, Japan Society for the Promotion of Science, JSPS)

Credentials

Education

Ph.D in Bioscience, Osaka University, Japan

Post-Doctoral Training

Visiting Scholar/Basic Life Research Scientist, Kobilka lab, Stanford University - April 2014 - July 2021

Postdoctoral Researcher, Paul Scherrer Institute, Villigen, Switzerland - August 2010 - March 2014

Research Fellow, Nakagawa Lab, Osaka University, Japan - April 2007 - March 2009

 

Published Articles or Reviews

  • Maeda S*, Xu J, Kadji FMN, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK*. Structure and selectivity engineering of the M1 muscarinic 1 receptor toxin complex: Science. 369, 161-167 (2020), PMID: 32646996 [* shared corresponding authors]
  • Tsai CJ, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NMI, Mohammed I, Matile H, Dawson RJP, Deupi X, Stahlberg H, Schertler GFX. Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit: eLife 2019;8:e46041, PMID: 31251171
  • Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Maeda S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK. Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy: Molecular Cell. 75, 1-13 (2019), PMID: 31103421
  • Maeda S*, Qianhui Q*, Robertson MJ, Skiniotis G, Kobilka BK. Structures of M1 and M2 muscarinic acetylcholine receptor/G-protein complexes: Science 364, 552-557 (2019), PMID: 31073061 [* equal 1st-authors]
  • Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. Development of an antibody fragment that stabilizes GPCR/G-protein complexes: Nat Commun. 9 (1) 3712. (2018), PMID: 30213947
  • Koehl A*, Hu H*, Maeda S*, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK. Structure of the mu-opioid receptor-Gi protein complex: Nature. 558 (7711), 547-552 (2018), PMID: 29899455 [* equal 1st authors]
  • Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T. Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor: Nat Chem Biol 14 (12), 1150-1158 (2018), PMID: 30420692

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