Warner-Lambert/Parke-Davis Professor of Medicine
Associate Chair, Department of Pharmacology
Professor of Pharmacology
[email protected]
Available to mentor
Yoichi Osawa
Professor
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Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. J Biol Chem, 2024 Jan; 300 (1): 105464Journal ArticleMapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
DOI:10.1016/j.jbc.2023.105464 PMID: 37979917 -
Huang X, Sun Y, Osawa Y, Chen YE, Zhang H. J Biol Chem, 2023 Aug; 299 (8): 105050Journal ArticleComputational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign.
DOI:10.1016/j.jbc.2023.105050 PMID: 37451479 -
Sun Y, Huang X, Osawa Y, Chen YE, Zhang H. Molecules, 2023 Jul 12; 28 (14):Journal ArticleThe Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering.
DOI:10.3390/molecules28145353 PMID: 37513226 -
Morishima Y, Lau M, Pratt WB, Osawa Y. J Biol Chem, 2023 Feb; 299 (2): 102856Journal ArticleDynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.
DOI:10.1016/j.jbc.2022.102856 PMID: 36596358 -
Cheng S, Bo Z, Hollenberg P, Osawa Y, Zhang H. J Biol Chem, 2021 296: 100645Journal ArticleAmphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase.
DOI:10.1016/j.jbc.2021.100645 PMID: 33839156 -
Felker D, Zhang H, Bo Z, Lau M, Morishima Y, Schnell S, Osawa Y. Biophys Chem, 2021 Jul; 274: 106590Journal ArticleMapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.
DOI:10.1016/j.bpc.2021.106590 PMID: 33894563 -
Davis AK, McMyn NF, Lau M, Morishima Y, Osawa Y. Mol Pharmacol, 2020 Sep; 98 (3): 243 - 249.Journal ArticleHsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.
DOI:10.1124/mol.120.119990 PMID: 32591478 -
2018 Oct 1;PresentationHsp90- and Hsp70- based Chaperone Machinery as a Heme Insertase
