Yoshihiro Morishima, MD, PhD
Associate Research Scientist
Pharmacology
[email protected]

Available to mentor

Yoshihiro Morishima, MD, PhD
Associate Research Scientist
  • Recent Publications
  • Recent Publications See All Publications
    • Journal Article
      Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
      Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. J Biol Chem, 2024 Jan; 300 (1): 105464 DOI:10.1016/j.jbc.2023.105464
      PMID: 37979917
    • Journal Article
      Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.
      Morishima Y, Lau M, Pratt WB, Osawa Y. J Biol Chem, 2023 Feb; 299 (2): 102856 DOI:10.1016/j.jbc.2022.102856
      PMID: 36596358
    • Journal Article
      Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.
      Felker D, Zhang H, Bo Z, Lau M, Morishima Y, Schnell S, Osawa Y. Biophys Chem, 2021 Jul; 274: 106590 DOI:10.1016/j.bpc.2021.106590
      PMID: 33894563
    • Journal Article
      Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.
      Davis AK, McMyn NF, Lau M, Morishima Y, Osawa Y. Mol Pharmacol, 2020 Sep; 98 (3): 243 - 249. DOI:10.1124/mol.120.119990
      PMID: 32591478
    • Journal Article
      Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
      Mehta RK, Pal S, Kondapi K, Sitto M, Dewar C, Devasia T, Schipper MJ, Thomas DG, Basrur V, Pai MP, Morishima Y, Osawa Y, Pratt WB, Lawrence TS, Nyati MK. Clin Cancer Res, 2020 Oct 1; 26 (19): 5246 - 5257. DOI:10.1158/1078-0432.CCR-19-3102
      PMID: 32718999
    • Proceeding / Abstract / Poster
      Cryo-EM Structural Analysis of Neuronal Nitric Oxide Synthase
      Pospiech TH, Morishima Y, Osawa Y, Southworth DR. Biophysical Journal, 2019 Feb; 116 (3): 187a - 188a. DOI:10.1016/j.bpj.2018.11.1040
    • Journal Article
      Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery
      Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. Molecular Pharmacology, 2018 Jun 25; 94: 984 - 991.
    • Additional Scholarship
      A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.
      Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. Exp Biol Med (Maywood), 2014 Nov; 239 (11): 1405 - 1413. DOI:10.1177/1535370214539444
      PMID: 24990484
    Featured News & Stories
    Department News
    Dr. Yoshihiro Morishima receives "Best Abstract"
    Dr. Yoshihiro Morishima, in the U-M Medical School Department of Pharmacology, has received "Best Abstract."