Frederick G L Huetwell Professor of Cardiovascular Medicine
Professor of Internal Medicine
Professor of Surgery
Professor of Pharmacology
Professor of Molecular and Integrative Physiology
[email protected]
Available to mentor
Yuqing E Chen
Professor
Dr. Chen is an expert in diabetes and cardiovascular disease. He cloned Exendin 4 (BYETTA), facilitating GLP1 drug development. He discovered the mechanisms of nitro-fatty acids, novel anti-inflammatory signaling molecules, currently in phase 2 clinical trials. Recently he embarked in successful integration of human genetic discoveries with translational research.
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Center MemberCenter for Integrative Research in Critical Care
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Center MemberCaswell Diabetes Institute
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberBiosciences Initiative
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Sun Y, Zhang Y, Zhang J, Chen YE, Jin J-P, Zhang K, Mou H, Liang X, Xu J. Cell Biosci, 2024 Feb 22; 14 (1): 27Journal ArticleXBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions.
DOI:10.1186/s13578-024-01203-x PMID: 38388523 -
Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866Journal ArticleHepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
DOI:10.1126/scitranslmed.adk1866 PMID: 38478630 -
Liang X, Hou X, Bouhamdan M, Sun Y, Song Z, Rajagopalan C, Jiang H, Wei H-G, Song J, Yang D, Guo Y, Zhang Y, Mou H, Zhang J, Chen YE, Sun F, Jin J-P, Zhang K, Xu J. JCI Insight, 2024 Feb 15;Journal ArticleSotagliflozin attenuates liver associated disorders in cystic fibrosis rabbits.
DOI:10.1172/jci.insight.165826 PMID: 38358827 -
Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Cell Metab, 2024 Jan 2; 36 (1): 116 - 129.e7.Journal ArticleSerine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
DOI:10.1016/j.cmet.2023.12.013 PMID: 38171331 -
Liu H, Zhao Y, Zhao G, Deng Y, Chen YE, Zhang J. Cells, 2024 Jan 16; 13 (2):Journal ArticleSWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies.
DOI:10.3390/cells13020168 PMID: 38247859 -
Zuo Y, Zhang C, Zhou Y, Li H, Xiao W, Herzog RW, Xu J, Zhang J, Chen YE, Han R. Cell Biosci, 2023 Jun 15; 13 (1): 109Journal ArticleLiver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice.
DOI:10.1186/s13578-023-01036-0 PMID: 37322547 -
Mizrak D, Zhao Y, Feng H, Macaulay J, Tang Y, Sultan Z, Zhao G, Guo Y, Zhang J, Yang B, Chen YE. Arterioscler Thromb Vasc Biol, 2023 Dec; 43 (12): 2285 - 2297.Journal ArticleSingle-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT-Expressing Smooth Muscle Cells.
DOI:10.1161/ATVBAHA.123.319329 PMID: 37823268 -
Tsai L-K, Peng M, Chang C-C, Wen L, Liu L, Liang X, Chen YE, Xu J, Sung L-Y. Cell Biosci, 2023 Oct 24; 13 (1): 193Journal ArticleZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells.
DOI:10.1186/s13578-023-01140-1 PMID: 37875990