Publications by our Researchers




Gene-set Enrichment with Mathematical Biology (GEMB)
GigaScience, Volume 9, Issue 10, October 2020, giaa091,
Amy L. Cochran, Kenneth J. Nieser, Daniel B. Forger, Sebastian Zöllner, Melvin G. McInnis

Optimizing an Acceptance and Commitment Therapy Microintervention Via a Mobile App With Two Cohorts: Protocol for Micro-Randomized Trials
Journal of Medical Internet Research, 9-23-2020, Vol 9, No 9. DOI: 10.2196/17086
Emily B Kroska, PhD; Sydney Hoel, BA; Amanda Victory, BA; Susan A Murphy, PhD; Melvin G McInnis, MD; Zachary N Stowe, MD; Amy Cochran, PhD 


A Smartphone App to Monitor Mood Symptoms in Bipolar Disorder: Development and Usability Study
Journal of Medical Internet Research Mental Health, 22.09.20 in Vol 7, No 9 (2020): September. DOI: 10.2196/19476 PMID: 32960185
Ryan KA, Babu P, Easter R, Saunders E, Lee AJ, Klasnja P, Verchinina L, Micol V, Doil B, McInnis MG, Kilbourne AM. 


MicroRNA Alterations in Induced Pluripotent Stem Cell-Derived Neurons From Bipolar Disorder Patients: Pathways Involved in Neuronal Differentiation, Axon Guidance, and Plasticity
Stem Cells and Development, 2020 Jun 17, doi: 10.1089/scd.2020.0046
Monica Bame, Melvin G McInnis, K Sue O'Shea


Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder
Chapter in the book Neurodevelopmental Disorders, publisher: Springer
24 June 2020, DOI: 10.1007/978-3-030-45493-7_8
D. Attili, D. J. Schill, C. J. DeLong, K. C. Lim, G. Jiang, K. F. Campbell, K. Walker, A. Laszczyk, M. G. McInnis, K. S. O’Shea


The association between lithium use and neurocognitive performance in patients with bipolar disorder
Neuropsychopharmacology, 29 April 2020,
Burdick, K.E., Millett, C.E., Russo, M. et al.


Decreased working memory capacity among individuals with a mood disorder who have increased metabolic burden
Journal of Affective Disorders, Volume 266, 1 April 2020, Pages 387-393,
Joel S. Peterman, David F. Marshall, Elena Lamping, Rebecca E. Easter, Pallavi Babu, Scott A. Langenecker, Melvin G. McInnis, Kelly A. Ryan



A comparative study of engagement in mobile and wearable health monitoring for bipolar disorder
Bipolar Disorders, 14 October 2019,
Kaela Van Til, Melvin G. McInnis, Amy Cochran

When to Intervene: Detecting Abnormal Mood using Everyday Smartphone Conversations
IEEE Transactions on Affective Computing, September 2019
John Gideon, Katie Matton, Steve Anderau, Melvin G McInnis, Emily Mower Provost


Emotion Recognition from Natural Phone Conversations in Individuals With and Without Recent Suicidal Ideation
Interspeech. Graz, Austria. September 2019
John Gideon, Heather T Schatten, Melvin G McInnis, Emily Mower Provost


Identifying Mood Episodes Using Dialogue Features from Clinical Interviews
Interspeech. Graz, Austria. September 2019
Zakaria Aldeneh, Mimansa Jaiswal, Michael Picheny, Melvin McInnis, Emily Mower Provost


Into the Wild: Transitioning from Recognizing Mood in Clinical Interactions to Personal Conversations for Individuals with Bipolar Disorder
Interspeech. Graz, Austria. September 2019
Katie Matton, Melvin G McInnis, Emily Mower Provost


Bipolar depression and suicidal ideation: Moderators and mediators of a complex relationship
Journal of Affective Disorders, Volume 259, 1 December 2019, Pages 164-172
Masoud Kamali, Noreen A. Reilly-Harrington, Weilynn C. Chang, Melvin McInnis, Susan L. McElroy, Terence A. Ketter, Richard C. Shelton, Thilo Deckersbach, Mauricio Tohen, James H. Kocsis, Joseph R. Calabrese, Keming Gao, Michael E. Thase, Charles L. Bowden, Gustavo Kinrys, William V. Bobo, Benjamin D. Brody, Louisa G. Sylvia, Dustin J. Rabideau, Andrew A. Nierenberg



Improving Cross-Corpus Speech Emotion Recognition with Adversarial Discriminative Domain Generalization (ADDoG)

IEEE Transactions on Affective Computing, 14 May 2019, doi: 10.1109/TAFFC.2019.2916092
John Gideon, Melvin McInnis, Emily Mower Provost



Jointly Aligning and Predicting Continuous Emotion Annotations
IEEE Transactions on Affective Computing, May 2019, DOI: 10.1109/TAFFC.2019.2917047
Soheil Khorram, Melvin McInnis, Emily Mower Provost



Trainable Time Warping: aligning time-series in the continuous-time domain
International Conference on Acoustics, Speech, and Signal Processing (ICASSP), Brighton, England. May 2019.
Soheil Khorram, Melvin McInnis, and Emily Mower Provost



OSCI: standardized stem cell ontology representation and use cases for stem cell investigation

BMC Bioinformatics, April 25, 2019, doi: 10.1186/s12859-019-2723-7
Yongqun He, William D. Duncan, Daniel J. Cooper, Jens Hansen, Ravi Iyengar, Edison Ong, Kendal Walker, Omar Tibi, Sam Smith, Lucas M. Serra, Jie Zheng, Sirarat Sarntivijai, Stephan Schürer, K. Sue O’Shea, and Alexander D. Diehl



The effect of mood phases on balance control in bipolar disorder
Journal of Biomechanics, Volume 82, 3 January 2019, Pages 266-270
Gu Eon Kang, Brian J. Mickey, Barry S. Krembs, Melvin G. McInnis, M. Melissa Gross






Motor behavior characteristics in various phases of bipolar disorder revealed through biomechanical analysis: Quantitative measures of activity and energy variables during gait and sit-to-walk
Psychiatry Research, Volume 269, November 2018, Pages 93-101,
Gu Eon Kang, Brian J. Mickey, Melvin G. McInnis, Barry S. Krembs, M. Melissa Gross


Mood, Dimensional Personality, and Suicidality in a Longitudinal Sample of Patients with Bipolar Disorder and Controls
Suicide and Life-Threatening Behavior, 19 November 2018,
Masoud Kamali, Erika F. H. Saunders, Shervin Assari, Kelly A. Ryan, David F. Marshall, Melvin G. McInnis

Ankyrin-G regulates forebrain connectivity and networksynchronization via interaction with GABARAP
Molecular Psychiatry, 19 November 2018,
A. D. Nelson, R. N. Caballero-Florán, J. C. Rodríguez Díaz, J. M. Hull, Y. Yuan, J. Li, K. Chen, K. K. Walder, L. F. Lopez-Santiago, V. Bennett, M. G. McInnis, L. L. Isom, C. Wang, M. Zhang, K. S. Jones & P. M. Jenkins 

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder
Neuropsychopharmacology, 16 November 2018
For a complete list of authors, please visit this link.


Cluster analysis with MOODS-SR illustrates a potential bipolar disorder risk phenotype in young adults with remitted Major Depressive Disorder
Bipolar Disorders; Volume 20, Issue 8; December 2018; Pages 697-707;
Leah R. Kling, Katie L. Bessette, Sophie R. DelDonno, Kelly A. Ryan, Wayne C. Drevets, Melvin G. McInnis, Mary L. Phillips, Scott A. Langenecker

Altered N170 and mood symptoms in bipolar disorder: An electrophysiological study of configural face processing
Bipolar Disorders; Volume 20; Issue 5; August 2018; Pages 477-487; doi: 10.1111/bdi.12587
Ivy F. Tso, Tyler B. Grove, Savanna A. Mueller, Lisa O’Donnell, Jinsoo Chun, Melvin G. McInnis, Patricia J. Deldin


A Bayesian model comparison approach to test the specificity of visual integration impairment in schizophrenia or psychosis
Psychiatry Research, Volume 265, July 2018, Pages 271-278,
Tyler B. Grove, Beier Yao, Savanna A. Mueller, Merranda McLaughlin, Vicki L. Ellingrod, Melvin G. McInnis, Stephan F. Taylor, Patricia J. Deldin, Ivy F. Tso

A Preliminary Study of Central Nervous System Arousal and Sleep Quality in Bipolar Disorder
Psychopathology, June 26, 2018. 51:269–275. DOI: 10.1159/000489679
Cardinale R., O'Donnell L., Chun J., Park J., Kross E., Kamali M., McInnis M., Deldin P.


Reliability, convergent validity and time invariance of default mode network deviations in early adult Major Depressive Disorder
Frontiers in Psychiatry; May 18, 2018; doi: 10.3389/fpsyt.2018.00244
Bessette, K. L.; Jenkins, L. M.; Skerrett, K. A.; Gowins, J. R.; Deldonno, S. R.; Zubieta, J., McInnis, M. G.; Jacobs, R. H.; Ajilore, O.; & Langenecker, S. A. 


Risk Factors Associated With Antidepressant Exposure and History of Antidepressant-Induced Mania in Bipolar Disorder

The Journal of Clinical Psychiatry; May 15, 2018;
Aislinn J. Williams, MD, PhD; Zongshan Lai, MD, MS; Seth Knight, MD; Masoud Kamali, MD; Shervin Assari, MD, MPH; and Melvin G. McInnis, MD, FRCPsych

Engagement Strategies for Self-Monitoring Symptoms of Bipolar Disorder With Mobile and Wearable Technology: Protocol for a Randomized Controlled Trial

JMIR-Journal of Medical Internet Research, Published on 10 May 2018 in Vol 7, No 5 (2018), doi:10.2196/resprot.9899
Amy Cochran, PhD;  Livia Belman-Wells;  Melvin McInnis, MD 

Let your fingers do the talking: Passive typing instability predicts future mood outcomes
Bipolar Disorders, 8 March 2018,
Jonathan P. Stange, John Zulueta, Scott A. Langenecker, Kelly A. Ryan, Andrea Piscitello, Jenna Duffecy, Melvin G. McInnis, Pete Nelson, Olusola Ajilore, Alex Leow

Harmonization of cortical thickness measurements across scanners and sites
NeuroImage, Volume 167, 15 February 2018, Pages 104-120, DOI: 10.1016/j.neuroimage.2017.11.024
Jean-Philippe Fortin, NicholasCullen, Yvette I. Sheline, Warren D. Taylor, Irem Aselcioglu, Philip A. Cook, Phil Adams, Crystal Cooper, Maurizio Fava, Patrick J. McGrath, Melvin McInnis, Mary L. Phillips, Madhukar H. Trivedi, Myrna M. Weissmang, Russell T. Shinohara

Developing Dimensional, Pandiagnostic Inhibitory Control Constructs With Self-Report and Neuropsychological Data
SAGE Journals, DOI: 10.1177/1073191118754704, First Published February 6, 2018 
Natania A. Crane, Alvaro Vergés, Masoud Kamali, Runa Bhaumik, Kelly A. Ryan, David F. Marshall, Erika F. H. Saunders, Michelle T. Kassel, Anne L. Weldon, Melvin G. McInnis, Scott A. Langenecker

Testing frameworks for personalizing bipolar disorder

Translational Psychiatry, Volume 8, Article number: 36 (2018), doi:10.1038/s41398-017-0084-4, published online: 02 February 2018
Amy L. Cochran, André Schultz, Melvin G. McInnis & Daniel B. Forger

Critical roles of αII spectrin in brain development and epileptic encephalopathy
The Journal of Clinical Investigation, Volume 128, Issue 2, Pages 545-889, published February 1, 2018
Yu Wang, Tuo Ji, Andrew D. Nelson, Katarzyna Glanowska, Geoffrey G. Murphy, Paul M. Jenkins, and Jack M. Parent 

Eye gaze perception in bipolar disorder: Self-referential bias but intact perceptual sensitivity

Bipolar Disorders; Volume 20, Issue 1; February 2018; Pages 60-69;
Beier Yao, Savanna A. Mueller, Tyler B. Grove, Merranda McLaughlin, Katharine Thakkar, Vicki Ellingrod, Melvin G. McInnis, Stephan F. Taylor, Patricia J. Deldin, Ivy F. Tso


Psychosis in bipolar disorder: Does it represent a more “severe” illness?
Bipolar Disorders; Volume 20, Issue 1; February 2018; Pages 18-26; 
Cynthia Z. Burton, Kelly A. Ryan, Masoud Kamali, David F. Marshall, Gloria Harrington, Melvin G. McInnis, Ivy F. Tso

Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in Bipolar Disorder
Psychoneuroendocrinology, Available online 31 January 2018
Alan R.Prossin, Matthew Chandler, Kelly A.Ryan, Erika F.Saunders, Masoud Kamali, Vassilios Papadopoulos, Sebastian Zöllner, Robert Dantzer, Melvin G. McInnis

Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling: Findings from the EMBARC study
Magnetic Resonance Imaging, Volume 45, January 2018, Pages 26-33
Jorge R.C. Almeida, Tsafrir Greenberg, Hanzhang Lu, Henry W. Chase, Jay C. Fournier, Crystal M. Cooper, Thilo Deckersbach, Phil Adams, Thomas Carmody, Maurizio Fava, Benji Kurian, Patrick J. McGrath, Melvin G. McInnis, Maria A. Oquendo, Ramin Parsey, Myrna Weissman, Madhukar Trivedi, Mary L. Phillips

Sleep disturbance may impact treatment outcome in bipolar disorder: A preliminary investigation in the context of a large comparative effectiveness trial

Journal of Affective Disorders, Volume 225, 1 January 2018, Pages 563-568
Louisa G. Sylvia, Weilynn C. Chang, Masoud Kamali, Mauricio Tohen, Gustavo Kinrys, Thilo Deckersbach, Joseph R. Calabrese, Michael E. Thase, Noreen Reilly-Harrington, William V. Bobo, James H. Kocsis, Melvin G. McInnis, Charles L. Bowden, Terence A. Ketter, Edward S. Friedman, Richard C. Shelton, Susan L. McElroy, Keming Gao, Dustin J. Rabideau, Andrew A. Nierenberg

Corrigendum to bipolar mixed features – Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study
Journal of Affective Disorders, Volume 225, 1 January 2018, Pages 775-777
Mauricio Tohen, Alexandra K. Gold, Louisa G. Sylvia, Rebecca E. Montana, Susan L. McElroy, Michael E. Thase, Dustin J. Rabideau, Andrew A. Nierenberg, Noreen A. Reilly-Harrington, Edward S. Friedman, Richard C. Shelton, Charles L. Bowden, Vivek Singh, Thilo Deckersbach, Terence A. Ketter, Joseph R. Calabrese, William V. Bobo, Melvin G. McInnis





Treatment to Enhance Cognition in Bipolar Disorder (TREC-BD): Efficacy of a Randomized Controlled Trial of Cognitive Remediation Versus Active Control
The Journal of Clinical Psychiatry, November/December 2017
Kathryn E. Lewandowski, PhD; Sarah H. Sperry, MA; Bruce M. Cohen, MD, PhD; Lesley A. Norris, BA; Garrett M. Fitzmaurice, PhD; Dost Ongur, MD, PhD; and Matcheri S. Keshavan, MD



Clinically relevant and simple immune system measure is related to symptom burden in bipolar disorder


Acta Neuropsychiatrica, 07 December 2017
Ole Köhler-Forsberg, Louisa Sylvia, Thilo Deckersbach, Michael Joshua Ostacher, Melvin McInnis, Dan Iosifescu, Charles Bowden, Susan McElroy, Joseph Calabrese, Michael Thase, Richard Charles Shelton, Mauricio Tohen, James Kocsis, Edward Friedman, Terence Ketter, Andrew Alan Nierenberg



Cohort Profile: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder


International Journal of Epidemiology, 02 December 2017
Melvin G McInnis, Shervin Assari, Masoud Kamali, Kelly Ryan, Scott A Langenecker, Erika F H Saunders, Kritika Versha, Simon Evans, K Sue O’Shea, Emily Mower Provost, David Marshall, Daniel Forger, Patricia Deldin, Sebastian Zoellner



Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts


Journal of the American Academy of Child and Adolescent Psychiatry, Volume 56, Issue 12 (December 2017)
Holly C. Wilcox, Janice M. Fullerton, Anne L. Glowinski, Kelly Benke, Masoud Kamali, Leslie A. Hulvershorn, Emma K. Stapp, Howard J. Edenberg, Gloria M.P. Roberts, Neera Ghaziuddin, Carrie Fisher, Christine Brucksch, Andrew Frankland, Claudio Toma, Alex D. Shaw, Elizabeth Kastelic, Leslie Miller, Melvin G. McInnis, Philip B. Mitchell, John I. Nurnberger Jr.



Social Aspects of the Workplace Among Individuals With Bipolar Disorder
Journal of the Society for Social Work and Research, Volume 8, Number 3 | Fall 2017
Lisa O’Donnell, Joseph A. Himle, Kelly Ryan, Andrew Grogan-Kaylor, Melvin G. McInnis, Jenna Weintraub, Marisa Kelly, Patricia Deldin



Pharmacokinetics and Pharmacogenomics of Bupropion in Three Different Formulations with Different Release Kinetics in Healthy Human Volunteers
The AAPS Journal - An Official Journal of the American Association of Pharmaceutical Scientists, September 2017, Volume 19, Issue 5, pp 1513–1522
Jamie N. Connarn, Stephanie Flowers, Marisa Kelly, Ruijuan Luo, Kristen M. Ward, Gloria Harrington, Ila Moncion, Masoud Kamali, Melvin McInnis, Meihua R. Feng, Vicki Ellingrod, Andrew Babiskin, Xinyuan Zhang, Duxin Sun



Equivalent linear change in cognition between individuals with bipolar disorder and healthy controls over 5 years
Bipolar Disorders; 14 September 2017;
Kelly A. Ryan, Shervin Assari, Kaley Angers, David F Marshall, Kristin Hinrichs, Rebecca Easter, Pallavi Babu, Bethany D. Pester, Scott A. Langenecker, Melvin G. McInnis



Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder
Proceedings of the National Academy of Sciences of the United States of America, September 11, 2017,  doi: 10.1073/pnas.1700689114
Shanshan Zhua, Zachary A. Cordner, Jiali Xiong, Chi-Tso Chiu, Arabiye Artola, Yanning Zuo, Andrew D. Nelson, Tae-Yeon Kim, Natalya Zaika, Brian M. Woolums, Evan J. Hess, Xiaofang Wang, De-Maw Chuang, Mikhail M. Pletnikov, Paul M. Jenkins, Kellie L. Tamashiro, and Christopher A. Ross



Depression and executive functioning deficits predict poor occupational functioning in a large longitudinal sample with bipolar disorder
Journal of Affective Disorders, Volume 215, June 2017, Pages 135–142, (link is external)
Lisa A. O’Donnell, Patricia J. Deldin, Andrew Grogan-Kaylor, Melvin G. McInnis, Jenna Weintraub, Kelly A. Ryan, Joseph A. Himle



The gut microbiome composition associates with bipolar disorder and illness severity
Journal of Psychiatric Research (2017), Volume 87, April 2017, Pages 23–29, doi: 10.1016/j.jpsychires.2016.12.007
Simon J. Evans, Christine M. Bassis, Robert Hein, Shervin Assari, Stephanie A. Flowers, Marisa B. Kelly, Vince B. Young, Vicky E. Ellingrod, Melvin G. McInnis



Cognitive flexibility: A trait of bipolar disorder that worsens with length of illness


Journal of Clinical and Experimental Neuropsychology, Issue 10, Pages 979-987, Published online: 09 Mar 2017
Lisa A. O’Donnell, Patricia J. Deldin, Bethany Pester, Melvin G. McInnis, Scott A. Langenecker, Kelly A. Ryan



Influence of Cognitive Reserve on Neuropsychological Functioning in Bipolar Disorder: Findings from a Five-Year Longitudinal Study


Bipolar Disorders, Volume 19, Issue 1, February 2017, Pages 50–59, doi: 10.1111/bdi.12470
Kristin H. Hinrichs, Rebecca E. Easter, Kaley Angers, Bethany Pester, Zongshan Lai, David F. Marshall, Masoud Kamali, Melvin McInnis, Scott A. Langenecker, Kelly A. Ryan



Bipolar disorder moderates associations between linoleic acid and markers of inflammation
Journal of Psychiatric Research (2017), Volume 85, February 2017, Pages 29–36
Ya-Wen Chang, Shervin Assari, Alan R. Prossin, Laura Stertz, Melvin G. McInnis, Simon J. Evans 



A Comparison of Mathematical Models of Mood in Bipolar Disorder


Computational Neurology and Psychiatry,  pp 315-341, 02 February 2017
Amy L. Cochran, André Schultz, Melvin G. McInnis, Daniel B. Forger



Trajectories of suicidal ideation over 6 months among 482 outpatients with bipolar disorder
Journal of Affective Disorders, Volume 223, 1 December 2017, Pages 146-152
Ole Köhler-Forsberg, Trine Madsen, Ida Behrendt-Møller, Louisa Sylvia, Charles L. Bowden, Keming Gao, William V. Bobo, Madhukar H. Trivedi, Joseph R. Calabrese, Michael Thase, Richard C. Shelton, Melvin McInnis, Mauricio Tohen, Terence A. Ketter, Edward S. Friedman, Thilo Deckersbach, Susan L. McElroy, Noreen A. Reilly-Harrington, Andrew A. Nierenberg






Interaction between Atypical Antipsychotics and the Gut Microbiome in a Bipolar Disease Cohort
Pharmacotherapy, 30 December 2016, doi: 10.1002/phar.1890
Stephanie A Flowers, Simon J Evans, Kristen M Ward, Melvin G McInnis, Vicki L Ellingrod

Neuroticism and Individual Differences in Neural Function in Unmedicated Major Depression: Findings from the EMBARC Study
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; Volume 2, Issue 2, March 2017, Pages 138-148; doi: 10.1016/j.bpsc.2016.11.008
Jay C. Fournier, Henry W. Chase, Tsafrir Greenberg, Amit Etkin, Jorge R. Almeida, Richelle Stiffler, Thilo Deckersbach, Sarah Weyandt, Crystal Cooper, Marisa Toups, Tom Carmody, Benji Kurian, Scott Peltier, Phillip Adams, Melvin G. McInnis, Maria A. Oquendo, Patrick J. McGrath, Maurizio Fava, Myrna Weissman, Ramin Parsey, Madhukar H. Trivedi, Mary L. Phillips

Identification of non-reported bupropion metabolites in human plasma
Biopharmaceutics & Drug Disposition, 1 December 2016, doi: 10.1002/bdd.2046
Jamie N. Connarn, Ruijuan Luo, Jim Windak, Xinyuan Zhang, Andrew Babiskin, Marisa Kelly, Gloria Harrington, Vicki L. Ellingrod, Masoud Kamali, Melvin McInnis, Duxin Sun

Data-driven classification of bipolar I disorder from longitudinal course of mood
Translational Psychiatry (2016) 6, e912; doi:10.1038/tp.2016.166; published online 11 October 2016
AL Cochran, MG McInnis, and DB Forger

Negative affect predicts social functioning across schizophrenia and bipolar disorder: Findings from an integrated data analysis
Psychiatry Research (2016), Volume 243, 30 September 2016, Pages 198–206, doi:10.1016/j.psychres.2016.06.031
Tyler B. Grove, Ivy F. Tso, Jinsoo Chun, Savanna A. Mueller, Stephan F. Taylor, Vicki L. Ellingrod, Melvin G. McInnis, Patricia J. Deldin

Recognition of depression in bipolar disorder: leveraging cohort and person-specific knowledge
Presented at Interspeech, September 8-12, 2016, San Francisco. Soheil Khorram, John Gideon, Melvin McInnis, Emily Mower Provost

The Splice Is Right: ANK3 and the Control of Cortical Circuits
Biological Psychiatry, Published: 15 August 2016, 80(4):263-5, DOI: 10.1016/j.biopsych.2016.06.006 Nelson AD, Jenkins PM

The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample
BMC Psychiatry, Published: 5 May 2016, DOI: 10.1186/s12888-016-0732-x
Ketil J. Oedegaard, Martin Alda, Anit Anand, Ole A. Andreassen, Yokesh Balaraman, Wade H. Berrettini, Abesh Bhattacharjee, Kristen J. Brennand, Katherine E. Burdick, Joseph R. Calabrese, Cynthia V. Calkin, Ana Claasen, William H. Coryell, David Craig, Anna DeModena, Mark Frye, Fred H. Gage, Keming Gao, Julie Garnham, Elliot Gershon, Petter Jakobsen, Susan G. Leckband, Michael J. McCarthy, Melvin G. McInnis, Adam X. Maihofer, Jerome Mertens, Gunnar Morken, Caroline M. Nievergelt, John Nurnberger, Son Pham, Helle Schoeyen, Tatyana Shekhtman, Paul D. Shilling, Szabolcs Szelinger, Bruce Tarwater, Jun Yao, Peter P. Zandi and John R. Kelsoe

Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder
BMC Psychology, Published: 2 April 2016, DOI: 10.1186/s40359-016-0118-3 
Stephanie A. Flowers, Kelly A. Ryan, Zongshan Lai, Melvin G. McInnis and Vicki L. Ellingrod

Similar Trajectory of Executive Functioning Performance over 5 years among individuals with  Bipolar Disorder and Unaffected Controls using Latent Growth Modeling
Journal of Affective Disorders, July 15, 2016, Volume 199, Pages 87–94. DOI: 10.1016/j.jad.2016.04.016
Kelly A. Ryan, Shervin Assari, Bethany D. Pester, Kristin Hinrichs, Kaley Angers, Amanda Baker, David F. Marshall, Deborah Stringea, Erika F.H. Saunders, Masoud Kamali, Melvin G. McInnis, Scott A. Langenecker

Mood State Prediction from Speech of Varying Acoustic Quality for Individuals with Bipolar Disorder
Presented at the 2016 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), March 20-25, 2016.
John Gideon, Emily Mower Provost, Melvin McInnis

A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report
Journal of Affective Disorders, March 1, 2016, 192, 212-218. DOI: 10.1016/j.jad.2015.12.036
Noreen A. Reilly-Harrington, Richard C. Shelton, Masoud Kamali, Dustin J. Rabideau, Leah W. Shesler, Madhukar H. Trivedi, Susan L. McElroy, Louisa G. Sylvia, Charles L. Bowden, Terence A. Ketter, Joseph R. Calabrese, Michael E. Thase, William V. Bobo, Thilo Deckersbach, Mauricio Tohen, Melvin G. McInnis, James H. Kocsis, Alexandra K. Gold, Vivek Singh, Daniel M. Finkelstein, Gustavo Kinrys, Andrew A. Nierenberg




Deficient inhibitory control as an outcome of childhood trauma
Psychiatric Research, December 11, 2015. DOI: 10.1016/j.psychres.2015.12.013
David F. Marshall, Alessandra M. Passarotti, Kelly A. Ryan, Masoud Kamali, Erika F.H. Saunders, Bethany Pester, Melvin G. McInnis, Scott A. Langenecker

Neurodevelopmental origins of bipolar disorder: iPSC models
Molecular and Cellular Neuroscience, December 1, 2015. DOI:10.1016/j.mcn.2015.11.006
K. Sue O'Shea and Melvin G. McInnis

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
Nature, November 5, 2015, 527, 95-99. DOI: 10.1038/nature15526
Jerome Mertens, Qiu-Wen Wang, Yongsung Kim, Diana X. Yu, Son Pham, Bo Yang, Yi Zheng, Kenneth E. Diffenderfer, Jian Zhang, Sheila Soltani, Tameji Eames, Simon T. Schafer, Leah Boyer, Maria C. Marchetto, John I. Nurnberger, Joseph R. Calabrese, Ketil J. Ødegaard, Michael J. McCarthy, Peter P. Zandi, Martin Alba, Caroline M. Nievergelt, The Pharmacogenomics of Bipolar Disorder Study, Shuangli Mi, Kristen J. Brennand, John R. Kelsoe, Fred H. Gage & Jun Yao

Longitudinal impact of a collaborative care model on employment outcomes in bipolar disorder
Journal of Affective Disorders,  December 1, 2015, Volume 188 , 239 - 242. DOI: 10.1016/j.jad.2015.08.052
Kelly A. Ryan, Daniel Eisenberg, Hyungjin M. Kim, Zongshan Lai, Melvin McInnis, Amy M. Kilbourne

Assessment of First and Second Degree Relatives of Individuals With Bipolar Disorder Shows Increased Genetic Risk Scores in Both Affected Relatives and Young At-Risk Individuals
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, July 16, 2015. 168 (7), 617-629. DOI: 10.1002/ajmg.b.32344
Janice M. Fullerton, Daniel L. Koller, Howard J. Edenberg, Tatiana Foroud, Hai Liu, Anne L. Glowinski, Melvin G. McInnis, Holly C. Wilcox, Andrew Frankland, Gloria Roberts, Peter R. Schofield, Philip B. Mitchell, John I. Nurnberger, and Bipolar High Risk Study Group, BiGS Consortium

Plasma linoleic acid partially mediates the association of bipolar disorder on self-reported mental health scales

Journal of Psychiatric Research, 14 June, 2015, 68 (2015) 61-67, doi:10.1016/j.jpsychires.2015.06.001
Simon J. Evans, Shervin Assari, Gloria J. Harrington, Ya-Wen Chang, Charles F. Burant, Melvin G. McInnis

Longitudinal studies: An essential component for complex psychiatric disorders
Neuroscience Research, 5 June 2015, doi:10.1016/j.neures.2015.05.004
Melvin G. McInnis, John F. Greden

Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States
Neural Plasticity, Volume 2015 (2015), Article ID 939780, 6 pages. 2015. doi:10.1155/2015/939780
A. R. Prossin, R. H. Yolken, M. Kamali, M. M. Heitzeg, J. B. Kaplow, W. H. Coryell, and M. G. McInnis

The effect of poor sleep quality on mood outcome differs between men and women: A longitudinal study of bipolar disorder
Journal of Affective Disorders, 15 July 2015. Volume 180. Pages :90-96. doi:10.1016/j.jad.2015.03.048
Erika F.H. Saunders, Julio Fernandez-Mendoza, Masoud Kamali, Shervin Assari, Melvin G. McInnis

Shared dimensions of performance and activation dysfunction in cognitive control in females with mood disorders
Brain, May 2015, 138 (5) 1424-1434; DOI: 10.1093/brain/awv070 
Kelly A. Ryan , Erica L. Dawson , Michelle T. Kassel , Anne L. Weldon , David F. Marshall , Kortni K. Meyers , Laura B. Gabriel , Aaron C. Vederman , Sara L. Weisenbach , Melvin G. McInnis , Jon-Kar Zubieta , Scott A. Langenecker

Complexity of Illness and Adjunctive Benzodiazepine Use in Outpatients With Bipolar I or II Disorder
Journal of Clinical Psychopharmacology, February 2015. 35(1):68-74. doi: 10.1097/JCP.0000000000000257
Bobo WV, Reilly-Harrington NA, Ketter TA, Brody BD, Kinrys G, Kemp DE, Shelton RC, McElroy SL, Sylvia LG, Kocsis JH, McInnis MG, Friedman ES, Singh V, Tohen M, Bowden CL, Deckersbach T, Calabrese JR, Thase ME, Nierenberg AA, Rabideau DJ, Schoenfeld DA, Faraone SV, Kamali M.

Induced Pluripotent Stem Cell (iPSC) Models of Bipolar Disorder
Neuropsychopharmacology Reviews, January 2015. 40:248–249; doi:10.1038/npp.2014.221
Sue O'Shea and Melvin G McInnis




Medical burden in bipolar disorder: findings from the Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study (Bipolar CHOICE)


Bipolar Disorders, August 2014. DOI: 10.1111/bdi.12243
Sylvia LG, Shelton RC, Kemp DE, Bernstein EE, Friedman ES, Brody BD, McElroy SL, Singh V,Tohen M, Bowden CL, Ketter TA, Deckersbach T, Thase ME, Reilly-Harrington NA, Nierenberg AA,Rabideau DJ, Kinrys G, Kocsis JH, Bobo WV, Kamali M, McInnis MG, Calabrese JR

Openness Predicts Cognitive Functioning in Bipolar Disorder

Journal of Affective Disorders, July 2014. DOI: 10.1016/j.jad.2014.06.038
Deborah Stringer, David Marshall, Bethany Pester, Amanda Baker, Scott A. Langenecker, Kaley Angers, Nicole Frazier, Christopher Archer, Masoud Kamali, Melvin McInnis, Kelly A. Ryan

The Arabic Diagnostic Interview for Genetic Studies: aDIGS: Psychometric Properties

The Arab Journal of Psychiatry (2014) Vol. 25, No. 1 Page (18–23)(dio: 10.12816/0004111)
Elie G. Karam, Ziad Kronfol, Mariana Salamoun, Lynn Farah, Marie Therese Nacouzi, 
Stephanie Loukieh, Yasmeen M Assad, Grace Aranki, Melvin G McInnis 

Dietary Intake and Plasma Metabolomic Analysis of Polyunsaturated Fatty Acids in Bipolar Subjects Reveal Dysregulation of Linoleic Acid Metabolism

Journal of Psychiatric Research, June 2014. DOI: 10.1016/j.jpsychires.2014.06.001
Simon J. Evans, PhD, Rachel N. Ringrosea, Gloria J. Harrington, Peter Mancuso, Charles F. Burantc, Melvin G. McInnis

The Role of Social Relationships in Bipolar Disorder: A Review

Psychiatry Research, June 2014. DOI: 10.1016/j.psychres.2014.05.047
Sarah Greenberg, Katherine L. Rosenblum, Melvin G. McInnis, Maria Muzik

Ecologically Valid Long-term Mood Monitoring of Individuals with Bipolar Disorder Using Speech

Presented at the 2014 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), May 4-9, 2014
Zahi N. Karam, Emily Mower Provost, Satinder Singh, Jennifer Montgomery, Christopher Archer, Gloria Harrington, Melvin G. Mcinnis

Gender Differences, Clinical Correlates, and Longitudinal Outcome of Bipolar Disorder With Comorbid Migraine(

Clinical Psychological Science, April 2014. doi: 10.4088/JCP.13m08623
Erika F. H. Saunders, MD; Racha Nazir, MD; Masoud Kamali, MD; Kelly A. Ryan, PhD; Simon Evans, PhD; Scott Langenecker, PhD; Alan J. Gelenberg, MD; and Melvin G. McInnis, MD

Regulating the High: Cognitive and Neural Processes Underlying Positive Emotion Regulation in Bipolar I Disorder

Clinical Psychological Science, April 9, 2014. doi:10.1177/2167702614527580
Jiyoung Park, Özlem Ayduk, Lisa O'Donnell, Jinsoo Chun, June Gruber, Masoud Kamali, Melvin G. McInnis, Patricia Deldin, and Ethan Kross

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

Translational Psychiatry (2014) 4, e375; doi:10.1038/tp.2014.12
H.M. Chen, C.J. DeLong, M. Bame, I. Rajapakse, T.J. Herron, M.G. McInnis, and K.S. O’Shea

The double burden of age and disease on cognition and quality of life in bipolar disorder

International Journal of Geriatric Psychiatry, February 2014. doi: 10.1002/gps.4084
Sara L. Weisenbach, David Marshall, Anne L.Weldon, Kelly A. Ryan, Aaron C. Vederman, Masoud Kamali, Jon-Kar Zubieta, Melvin G. McInnis, and Scott A. Langenecker

Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE): a pragmatic trial of complex treatment for a complex disorder

Clin Trials. 2014 Feb;11(1):114-27. doi: 10.1177/1740774513512184. 
Nierenberg AA1, Sylvia LG, Leon AC, Reilly-Harrington NA, Shesler LW, McElroy SL, Friedman ES, Thase ME, Shelton RC, Bowden CL, Tohen M, Singh V, Deckersbach T, Ketter TA, Kocsis JH, McInnis MG, Schoenfeld D, Bobo WV, Calabrese JR; Bipolar CHOICE Study Group.




Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics
Cardiovascular Psychiatry and Neurology, vol. 2013, Article ID 596945, 8 pages, 2013. doi:10.1155/2013/596945
Kyle J. Burghardt, Kristen N. Gardner, Joshua W. Johnson, and Vicki L. Ellingrod

Emotion perception and executive functioning predict work status in euthymic bipolar disorder
Psychiatry Research, Volume 210, Issue 2, 15 December 2013, Pages 472–478
Kelly A. Ryan,  Aaron C. Vederman, Masoud Kamali, David Marshall, Anne L. Weldon, Melvin G. McInnis, Scott A. Langenecker

Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population.
Bipolar Disorder. 2013 Dec 13. doi: 10.1111/bdi.12160.
Bly MJ1, Taylor SF, Dalack G, Pop-Busui R, Burghardt KJ, Evans SJ, McInnis MI, Grove TB, Brook RD, Zöllner SK, Ellingrod VL.

Can P300 distinguish among schizophrenia, schizoaffective and bipolar I disorders? An ERP study of response inhibition
Schizophrenia Research, Volume 151, December 2013, Pages 175–184 
J. Chun, Z.N. Karam, F. Marzinzik, M. Kamali, L. O'Donnell, I.F. Tso, T.C. Manschreck, M. McInnis, P.J. Deldin

Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder. 
Journal of Affective Disorders151(2), 722-727. (2013).
Sylvia, L. G., Tohen, M., Mcinnis, M. G., Kamali, M., Friedman, E. S., Kocsis, J. H., et al.

Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population
Bipolar Disorders, 1 August 2013, doi: 10.1111/bdi.12160
Michael J. Bly, Stephan F. Taylor, Gregory Dalack, Rodica Pop-Busui, Kyle J. Burghardt, Simon J. Evans, Melvin McInnis, Tyler B. Grove, Robert D. Brook, Sebastian K. Zoellner, and Vicki L. Ellingrod

Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events
International Journal of Bipolar Disorders 2013, 1:16  (doi:10.1186/2194-7511-1-13)Erika F.H. Saunders, Danielle M. Novick, Julio Fernandez-Mendoza, Masoud Kamali, Kelly A. Ryan, Scott A. Langenecker, Alan J. Gelenberg and Melvin G. McInnis

Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders
International Journal of Bipolar Disorders 2013, 1:13 (doi:10.1186/2194-7511-1-13)
Andrew Jen, Erika F.H. Saunders, Rollyn M. Ornstein, Masoud Kamali and Melvin G. McInnis

C9ORF72 expansion in a family with bipolar disorder
Bipolar Disorders15(3), 326-332. (2013)
Meisler, M. H., Langenecker, S. A., Mcinnis, M. G., Lieberman, A. P., Albin, R. L., Kamali, M., et al.

A Pilot Study Investigating Tumor Necrosis Factor-[alpha] as a Potential Intervening Variable of Atypical Antipsychotic-Associated Metabolic Syndrome in Bipolar Disorder.
Therapeutic Drug Monitoring. 35(2):194-202, April 2013. 
Prossin AR, Zalcman SS, Evans SJ, McInnis MG, Ellingrod VL.

Gene expression alterations in bipolar disorder postmortem brains
Bipolar Disorders, Volume 15, Issue 2, March 2013, Pages 177-187
Haiming Chen, Nulang Wang, Xin Zhao, Christopher A. Ross, K. Sue O’Shea, Melvin G. McInnis




The Influence of the Brain-Derived Neurotropic Factor Val66Met -Genotype and HMG-CoA Reductase Inhibitors on Insulin Resistance in the Schizophrenia and Bipolar Populations
Clinical and Translational Science, 5: 486–490. doi: 10.1111/cts.12001
Burghardt, K.J., Pop-Busui, R., Bly, M.J., Grove, T.B., Taylor, S.F. and Ellingrod, V.L. (2012)

Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder
Psychiatry Research, Volume 200, Issues 2–3, 30 December 2012, Pages 252–257 
David F. Marshall, Sara J. Walker, Kelly A. Ryan, Masoud Kamali, Erika F.H. Saunders, Anne L. Weldon, Kenneth M. Adams, Melvin G. McInnis, Scott A. Langenecker

Reduced emotion processing efficiency in healthy males relative to females
Soc Cogn Affect Neurosci (2014) 9 (3): 316-325 first published online November 29, 2012 doi:10.1093/scan/nss137
Sara L. Weisenbach, Lisa J. Rapport, Emily M. Briceno, Brennan D. Haase, Aaron C. Vederman, Linas A. Bieliauskas, Robert C. Welsh, Monica N. Starkman, Melvin G. McInnis, Jon-Kar Zubieta, and Scott A. Langenecker

Association of plasma omega-3 and omega-6 lipids with burden of disease measures in bipolar subjects
Psychiatric Research, Volume 46, Issue 11, November 2012, Pages 1435–1441Simon J. Evans, Masoud Kamali, Alan R. Prossin, Gloria J. Harrington, Vicki L. Ellingrod, Melvin G. McInnis, Charles F. Burant

Modality-specific alterations in the perception of emotional stimuli in Bipolar Disorder compared to Healthy Controls and Major Depressive Disorder
Cortex, Volume 48, Issue 8, September 2012, Pages 1027–1034
Aaron C. Vederman, Sara L. Weisenbach, Lisa J. Rapport, Hadia M. Leon, Brennan D. Haase, Lindsay M. Franti, Michael-Paul Schallmo, Erika F.H. Saunders, Masoud M. Kamali, Jon-Kar Zubieta, Scott A. Langenecker, Melvin G. McInnis

Differential executive functioning performance by phase of bipolar disorder
Kelly A. Ryan, Aaron C. Vederman, E. Michelle McFadden, Anne L. Weldon, Masoud Kamali, Scott A. Langenecker and Melvin G. McInnis

Fats and Factors: Lipid Profiles Associate with Personality Factors and Suicidal History in Bipolar Subjects
Simon J. Evans, Alan R. Prossin, Gloria J. Harrington, Masoud Kamali, Vicki L. Ellingrod, Charles F. Burant, Melvin G. McInnis


2011 - 2007


Associations between suicide attempts and elevated bedtime salivary cortisol levels in bipolar disorder
Journal of Affective DisordersAvailable online 10 December 2011Masoud Kamali, Erika F.H. Saunders, Alan R. Prossin, Christine B. Brucksch, Gloria J. Harrington, Scott A. Langenecker, Melvin G. McInnis 

A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
BMC Systems Biology, 4(1), 158. (2010).
Mceachin, R. C., Chen, H., Sartor, M. A., Saccone, S. F., Keller, B. J., Prossin, A. R., et al.

Intermediate: Cognitive phenotypes in bipolar disorder
Journal of Affective DisordersVolume 122, Issue 3May 2010Pages 285-293 (doi:10.1016/j.jad.2009.08.018)
Scott A. Langenecker, Erika F.H. Saunders, Allison M. Kade, Michael T. Ransom, Melvin G. McInnis

Suggestive linkage at 9p22 in bipolar disorder weighted by alcohol abuse
Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5; 150B(8):1133-8.
Saunders EF, Zhang P, Copeland JN, Mclnnis MG, Zoellner S.
2009 Wiley-Liss, Inc. PMID: 19259988

Bayesian EM Algorithm for Scoring Polymorphic Deletions From SNP Data and Application to a Common CNV on 8q24
Genet. Epidemiol. 33:357–368, 2009.
Sebastian Zoellner, 1–4; Gang Su, 3; William C. L. Stewart, 1,4; Yi Chen, 1; Melvin G McInnis, 2; and Margit Burmeister, 2–5
1 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan
2 Department of Psychiatry, University of Michigan, Ann Arbor, Michigan
3 Bioinformatics Program, University of Michigan, Ann Arbor, Michigan
4 Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan
5 Department of Human Genetics, University of Michigan, Ann Arbor, Michigan

Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7501-6. Epub 2009 Apr 28.
Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M.

Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach
Article appeared in BioData Mining 2008, 1:2  (doi:10.1186/1756-0381-1-2)
© 2008 McEachin et al; licensee BioMed Central Ltd.

Richard C. McEachin, Benjamin J. Keller, Erika F.H. Saunders, Melvin G. McInnis

Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health Bipolar sample
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 
Volume 147B, Issue 1, pages 18–26, 5 January 2008
Article first published online: 24 MAY 2007
Erika H. Saunders, Laura J. Scott, Melvin G. McInnis, Margit Burmeister
(doi: 10.1002/ajmg.b.30558)