Modeling Mood Course to Detect Markers of Effective Adaptive Interventions

Bipolar disorder is successfully treated by combining medication with psychosocial therapy, but care can prove inadequate in practice. With gaps in coverage and medication, along with imprecise guidelines on when, where, and how to intervene, promising psychosocial therapies require adaptive strategies to better address the specific needs of individuals in a timely manner. Accomplishing this, however, requires evidence-based practices for adapting a psychosocial therapy. The long-term goal of this study is to address this knowledge gap, by establishing a mobile health platform for translating a psychosocial therapy in bipolar disorder into an effective adaptive intervention.

For this study, we will evaluate the feasibility of a micro-randomized trial in Acceptance and Commitment Therapy (ACT) utilizing interviews, wearing of Fitbit, self-report questionnaires and completion of microintervention questions. Our secondary outcome is to detect a linear effect in time of the microintervention on symptom levels of mania and depression in individuals with bipolar disorder.

This study has received approval from: IRBMED HUM00126732