Brain Networks Study Becomes the Largest Neuroimaging Dataset on Bipolar Disorder

The human brain is a complex interconnected network that dynamically changes in response to situational needs. These networks are potentially altered in bipolar disorder, which may help to explain impulsive decision-making in the condition. In 2022, the Sripada Lab, directed by Chandra Sripada, M.D., Ph.D., in collaboration with Melvin McInnis, M.D., Director of the Prechter Bipolar Program, received a 5-year NIH R01 grant ($2.6 million total) to study alterations in brain networks in bipolar disorder using functional magnetic resonance imaging (fMRI). Through the tireless work of lead research assistants Isabel Carley and Lauren Busuito, we have now reached a key milestone: With over 140 people recruited, this project is now the largest neuroimaging study ever of bipolar disorder!  There is much work to do, but it is worth pausing to celebrate this milestone – an important step along the way to improving diagnosis and treatment of bipolar disorder.