Zero To Thrive is built on the premise that the period from pregnancy through early childhood is an especially sensitive time for mitigating the multi-generational effects of inequity, trauma, and adversity and promoting mental health. We believe that providing families, from the start, with cutting-edge treatment and tools needed to sustain nurturing, supportive relationships will serve as a protective buffer that allows families to thrive now and into the next generation. Z2T will therefore harness the power of collaboration across the University of Michigan and with communities to create a portfolio of research, treatment, training, and advocacy initiatives that support well-being and resilience across two generations.