Michal Olszewski, D.V.M., Ph.D.

Associate Professor, Department of Internal Medicine
Research Biologist, Ann Arbor Veterans Affairs Healthcare System
Veterans Affairs Ann Arbor Healthcare System
Room 11R
2215 Fuller Road
Ann Arbor, MI 48105-2399
Phone: 734-845-5238

Administrative Contact

Lisa Reed 734-764-4554

Areas of Interest

Research Interests:   Scientific interest of our group focuses on the host-pathogen interaction at the interface of the adaptive and innate immunity. The effects of these interactions on the development of protective responses against fungal and bacterial pathogens are a common theme of these studies. Following areas of investigation have been established.    Mechanisms involved in pathogenesis of Cryptococcus neoformans infection and persistence of this microbe are main focus of our work. The interplay between the host and microbial factors especially, the role of microbial factors, urease, laccase-lac1, ena1, pyk1, rub1, vad1 and Hsp70 homologue Ssa1 on different aspects of innate and adaptive host response.    Studies of macrophage M1/M2 polarization and their plasticity in the context of cryptococcal infection Alternative activation of macrophages promotes persistence of C. neoformans we look into the mechanisms that promote and or prevent the alternative activation. These mechanisms include cytokines, direct effects of cryptococcal virulence factors, and pattern recognition receptors such as TLR9. We study how these factors affect macrophage biology in context of cryptococcal infection. Studies of the role of macrophage lysosomal damage and its effects on macrophage fungicidal activities and cryptococcal antigen cross-presentation.    Differential outcomes of infections are observed in various strains of mice infected with C. neoformans. We are interested in inheritance of these factors and the evaluation how genetic differences affect phenotype of the immune response to C. neoformans.  Mechanisms modulating the development of the adaptive immune responses to C. neoformans, particularly the role of cytokines, chemokines and growth factors including TNF-alpha and IL-12, CCL7 (MCP-3), CCL3 (MIP-1 alpha) and GMCSF. Effects of these factors during the early responses (dendritic cells and macrophages) and their subsequent effects on T cell response polarization are studied.  

Credentials

Degrees

D.V.M., 1988, Warsaw University of Life Sciences
Ph.D., 1997, Michigan State University

Fellowships

Postdoctoral Research Fellow, "Multidisciplinary Research Training in Lung Diseases", Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI (03/1998-08/1999)        

Postdoctoral Research Fellow, Investigator Training in Pulmonary Immunology. VA Career Development/Research Enhancement Award Program, VA Medical Center, Ann Arbor, MI (08/1999-10/2002)

Faculty Appointment Date

01/12/2003

Published Articles via PubMed