Production and Research

A full spectrum of synthetic precursors – [11C]carbon dioxide, [11C]carbon monoxide, [11C]cyanide, [11C]methyl iodide, [11C]methyl triflate, [18F]fluoride ion, [15O]oxygen, [13N]ammonia – are readily available for both research and clinical radiopharmaceutical synthesis.

We routinely prepare radiopharmaceuticals for clinical application in cardiology, neurology and oncology. Use the links below to navigate radiopharmaceuticals currently prepared in the University of Michigan PET Center.

Radiopharmaceutical Production

Fluorine – 18 Labeled Radiopharmaceutical Preparation

  • [18F]FDG
  • [18F]NaF
  • [18F]FLT (cell proliferation)
  • [18F]FAZA (hypoxia)
  • [18F]Flubatine (NAChRs)
  • [18F]Fluorocholine (prostate cancer)
  • [18F]FEOBV (VAChT)
  • [18F]MPPF (5HT-1A)
  • [18F]MHPG / PHPG (cardiac NET)

Carbon-11 Labeled Radiopharmaceutical Preparation

  • [11C]Acetate (TCA cycle – cardiac, oncology)
  • [11C]Carfentanil (mu opioid)
  • [11C]Choline (oncology)
  • [11C]DASB (SERT)
  • [11C]DTBZ (VMAT2)
  • [11C]FMZ (BZD)
  • [11C]HED (adrenergic)
  • [11C]LY2795050 (Kappa opioid)
  • [11C]Methionine (oncology)
  • [11C]OMAR
  • [11C]Palmitate (cardiac)
  • [11C]PBR28 (neuro, cardiac and oncology)
  • [11C]PiB (amyloid)
  • [11C]PMP (acetylcholinesterase)
  • [11C]Raclopride (dopamine)
  • [11C]Sarcosine (oncology)

Nitrogen-13 Labeled Radiopharmaceutical Preparation

  • [13N]NH3

Gallium-68 Labeled Radiopharmaceutical Preparation (PENDING)

  • [68Ga]Dotatate
  • [68Ga]PSMA

Radionuclide Production

The GE PETtrace is a two particle, fixed energy negative ion cyclotron. It produces protons and deuterons and is capable of simultaneous irradiation of two targets (six targets are on the machine). Targets for the production of carbon-11 (as CO2 and HCN), nitrogen-13 (as ammonia or nitrates/nitrites), oxygen-15 (as O2, from either proton or deuteron reactions) and fluorine-18 (as fluoride ion) are currently in routine operation.

Radiopharmaceutical Preparation

Radiopharmaceutical Production Laboratory

Quality Assurance

For more information on our QC Laboratory, please contact: Brian Hockley

microPET Pre-Clinical Imaging

Both a microPET R4 tomograph and a microPET P4 from Concorde Microsystems, Inc. are housed within our research laboratories for animal studies. The R4 system is for rodent (small animal) imaging, while the P4 has a larger field-of-view (FOV) sufficient for primate and small dog imaging as well as rodents.

Each system consists of 32 rings of LSO detector crystals providing an ~8 cm axial FOV. The R4 scanner has 192 detectors per ring giving an in-plane FOV of ~10 cm, while the P4 scanner has 336 detectors per ring giving an in-plane FOV of ~21 cm. Resolution for both sytems is 2 mm. Each tomograph is operated on a Dell Xeon dual 3.0 GHz processor workstation. Additional PC systems are also available for image reconstructions and analyses. 

Automated systems for assay of arterial blood radionuclide concentrations are readilty available fo refficient recording of smaple times, well coutner count rates, and automatic decay correction of the data. Animal research on this system is used for the evaluation of new radiotracers developed in the nuclear medicine research labratories, validation of new quantitative PET methodologies, as well as study of physiology and biochemistry.

 

(www.biospacelab.com) combined microSPECT/CT instrument was installed in January 2005. This provides improved SPECT imaging resolution (approximate 2 mm), with fully matched CT capabilities (for combining anatomical and moleculare imaging).

For more information or to schedule a microPET / microSPECT study, please contact: Phil Sherman