Corey Speers

Corey Speers, MD, PhD

Assistant Professor

Veterans Affairs Hospital and

University Hospital, B2C490

1500 E Medical Center Dr

Ann Arbor, MI 48109-5010

734-936-4300

Clinical Contacts

734-936-4300

Administrative Contact

Kelley Coppola 734-936-7810

Biography

Our laboratory research includes nomination and validation of expression-based signatures to predict patients that need treatment intensification and signatures to identify patient who will not need further adjuvant therapy for breast cancer. Moreover, our translational work has credentialed a number of novel targets for the treatment of estrogen and progesterone receptor-negative, HER2-negative “triple-negative” breast cancer, a particularly aggressive and difficult to treat form of breast cancer.  As PI or co-Investigator on several university-, industry-, private foundation- and NIH-funded grants, we remain active in the radiation and breast cancer research arena by looking for more effective, targeted therapies for women with breast cancer. These targeted therapies include PARP-inhibitors, BET bromodomain inhibitors, and androgen receptor antagonists as agents for radiosensitization. We have also utilized kinome screens to identify novel targets for the treatment of aggressive breast cancers, including triple-negative breast cancer. Finally, we are also interested in the mechanisms of treatment resistance that include modulation of breast tumor initiating cells and understanding novel layers of cancer biology, including the role of long non-coding RNA in triple-negative breast cancer.

Areas of Interest

  • Breast cancer- clinical and scientific interest include using genomic and proteomic approaches to identify women who are at high risk for breast cancer recurrence and who may benefit from treatment intensification. Interests also include molecularly based signatures to identify women who are cured after breast conserving surgery and who may not require adjuvant radiation.
  • Radiation therapy for breast cancer- Interest includes identifying novel molecular targets for chemo‐ and radio-sensitization in women with triple‐negative or basal‐like breast cancer, including those molecules critical for maintaining breast cancer stem cells.
  • Radiation therapy for prostate cancer- Interest includes the identification of molecular targets relevant for the systemic progression and radiation sensitization of prostate cancer.

Clinical Interests

  • Avoiding the over- and under- treatment of patients with breast or prostate cancer

Honors & Awards

 2017  Selected for the Frank Limpert Clinical Scholar Career Development Award
 2016  Selected as the Frances and Kenneth Eisenberg  Emerging Scholar from the Taubman Institute
 2015  Awarded Roentgen Resident/Fellow Research Award for outstanding research 
 2014  Awarded Young Oncologist Essay Award and Oral presentation, American Radium Society 96th Annual Meeting
 2014  Awarded the 2014 ASCO Conquer Cancer Foundation Young Investigator Awardin memory of Evelyn H. Lauder
 2014  ASTRO Annual Meeting Abstract Award, Basic Science Abstract Award Winner in Biology, oral presentation 
 2014  Best of ASTRO meeting selection
 2014  “Best of ASTRO” selection, for abstract: Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Target for Radiosensitization That  is Independently Prognostic in Triple-Negative Breast Cancers; presented at Best of ASTRO meeting, Oct 17-18th, Miami, FL
 2013  AACR Scholar-in-Training Award
 2013  San Antonio Breast Cancer Symposium 
2013   Awarded Radiological Society of North America (RSNA) Research & Education Foundation's Resident Research Grant, 1 year award. 
 2012  Selected as a B. Leonard Holman Research Pathway Fellow by the AmericanBoard of Radiology. 
 2008  Invited platform speaker, Era of Hope Biannual Meeting, Baltimore, MD

Credentials

  • PhD, Department of Molecular and Cellular Biology, Baylor College of Medicine, 2009.
  • MD, Baylor College of Medicine, 2010
  • BS, Brigham Young University, Provo, UT, 2002
  • Medical License: State of Michigan

Grants

  • (PI: Speers), 01/2017-12/2021, Frances and Kenneth Eisenberg Emerging Scholar of the Taubman Institute,
  •  (PI: Speers), 01/2017-12/2017, Frank Limpert Clinical Scholar Career Development Award Dr. Frank Limpert
  • (PI: Pierce), 10/2016-09/2017, Breast Cancer Research Fdn- 16-PAF07572: Breast cancer cell sensitivity to radiotherapy In the presence of targeted therapies and predictors of early vs. late response,  Role; Co-Investigator with Effort.
  • (PI: Pierce), 07/2016-03/2018, Susan G. Komen for the Cure: Breast cancer cell sensitivity to radiotherapy in the presence of targeted therapies, Co-Investigator with Effort.
  •  (PI: Speers), 07/2015-02/2018m Astellas Pharma US, Inc. through a consortium with Medivation, Inc.- 14-PAF05472: Androgen receptor blockade as a novel radiosensitization strategy in AR-positive, triple-negative breast cancer, Role: Principal Investigator.

Published Articles via Michigan Experts or PubMed

Published Articles or Reviews

Selected from 22 publications

  • Speers C, Liu M, Zhao S, Evans J, Pierce LJ, Feng F. Maternal embryonic leucine zipper kinase(MELK) is a novel radioresistance gene and a biomarker of radioresistance in human breast cancer.  Clin Cancer Res, Aug 15;21(16):3667-77, 2015. PMID: 27225691
  • Speers C*, Zhou S*, Liu M, Bartelink H,   Pierce LJ, Feng FY. Development and validation of a novel radiosensitivity signature in human breast cancer. Clin Cancer Res, Apr 22, 2014 pii:clincanres.2898.2014.
  • Speers C*, Feng FY*, Liu M, Jackson W, Moon D, Rinkinen J, Wilder-Romans K, JagsiR, Pierce LJ. Intratreatment increases in PARP1 activity predict radiosensitization with PARP1 inhibition in breast cancer. Breast Cancer Res Treat, Aug;147(1):81-94, 2014.
  • Niknafs YS, Han S, Ma T, Speers C, Evans J, Poliakov A,  Rae J, Hayes D, Malik R, Singhal U, Rolf, Cenk, George,Feng F, Chinnaiyan AF, An estrogen regulated long non-coding RNA mediates breast cancer progression and tamoxifen resistance, Nat Commun,  Sep 26;7:12791. 2016. doi:10.1038/ncomms12791. PMID: 27666543
  • Zhao SG, Chang SL, Spratt DE, Erho N, Yu M, Ashab HA, Alshalalfa M, Speers C, Tomlins SA, Davicioni E, Dicker AP, Carroll PR, Cooperberg MR, Freedland SJ, Karnes RJ, Ross A, Schaeffer EM, Den RB, Nguyen PL, Feng FY, A 24-gene predictor of response to post-operative radiation therapy in prostate cancer. Lancet Oncology, Oct 12. pii: S1470-2045(16)30491-0, 2016. PMID: 27743920

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