Paramita Ray

Paramita Ray, PhD

Assistant Research Scientist

Medical Science I, Rm 4311

1301 Catherine St

Ann Arbor, MI 48109

734-763-2198

Biography

Dr. Ray has over 10 years of research experience in the field of cell and developmental biology. She obtained her PhD in 2007 from the Department of Biological Sciences at the University of Illinois at Chicago (UIC), where she studied the neurodevelopment of Caenorhabditis elegans. During her postdoctoral studies she became interested in cancer biology where she studied the role of chemokine receptors (CXCR4 and CXCR7) in breast cancer metastasis. As a Research Investigator in the Department of Radiation Oncology she studies factors that regulate the stability of various oncoproteins including Epidermal Growth Factor Receptor (EGFR) and mutant KRAS. She is also actively involved in collaborative research identifying ubiquitin ligases (E3s) responsible for regulating protein stabilities of various oncogenes including mutant TP53 and CYP24A1.

Areas of Interest

  • Factors regulating EGFR protein stability.
  • Oncogenic potential of CYP24A1 in lung cancer progression.
  • Understanding the role of GRAIL in Barrett’s progression to esophageal adenocarcinoma (EAC).

Credentials

  • PhD, University of Illinois, Chicago, 2007

Published Articles or Reviews

Selected from 14 publications

  • Ray P, Tan YS, Somnay V, Mehta R, Sitto M, Ahsan A, Nyati S, Naughton JP, Bridges A, Zhao L, Rehemtulla A, Lawrence TS, Ray D, Nyati MK. Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors. Oncotarget. In press. PMID: 27612423.
  • Ray P, Lewin SA, Mihalko LA, Schmidt BT, Luker KE, Luker GD: Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4. Neoplasia. 13(12):1152-61, 2011. PMCID: PMC3257190.
  • Luker KE, Mihalko LA, Schmidt BT, Lewin SA, Ray P, Shcherbo D, Chudakov DM, Luker GD. In vivo imaging of ligand receptor binding with Gaussia luciferase complementation. Nature Medicine 18(1):172-7, 2011. PM22138753.
  • Ray P, Lewin SA, Mihalko LA, Lesher-Perez SC, Takayama S, Luker KE, Luker GD. Secreted CXCL12 (SDF-1) forms dimers under physiological conditions. The Biochemical Journal. 442(2):433-42, 2012. PM22142194.
  • Ray P, Schnabel R, Okkema PG. Behavioral and synaptic defects in C. elegans lacking the NK-2 homeobox gene ceh-28. Developmental Neurobiology. 68(4):421-33, 2008. PM1816185