Qiang Zhang

Qiang Zhang, PhD

Research Assistant Professor

Med Sci I, Room 4326B
1301 Catherine St
Ann Arbor, MI 48109-5637

Biography

Dr. Zhang’s has over 15 years of research experience in the field of cancer biology with specific emphasis on identifying novel molecular targets in pancreatic cancer that are important in the response to radiation and immune checkpoint inhibitors. He is involved with several translational therapeutic projects to optimize the use of agents targeting ATM, PARP, DNA-PK, and FBXW7, in pancreatic cancer. Dr. Zhang also has extensive experience in mechanism-based studies of DNA double-strand break repair pathways and protein post-translational modifications. His expertise in laser microirradiation was essential in establishing this platform in the Experimental Irradiation Shared Resource in the UMCCC. 

Areas of Interest

  • Targeting DNA damage repair pathways for radiotherapy and immune checkpoint inhibition in pancreatic cancer
  • Identifying novel molecular mechanisms in DNA double-strand break repair

Credentials

PhD: Peking Union Medical College, Beijing, China 2009

Grants

  • R01 (CA240515), National Institutes of Health: Targeting the DNA damage response in combination with radiation to induce innate immunity and improve immunotherapy efficacy in pancreatic cancer, 08/2020-07/2025, Role: co-Investigator

Published Articles or Reviews

Selected from 40 publications

  1. Zhang Q, Green MD, Lang X, Lazarus J, Parsels JD, Wei S, Parsels LA, Shi J, Ramnath N, Wahl DR, Pasca di Magliano M, Frankel TL, Kryczek I, Lei YL, Lawrence TS, Zou W, Morgan MA: Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy. Cancer Res 79(15): 3940-3951, 2019. PM31101760/PMC6684166
  2. Zhang Q, Mady ASA, Ma Y, Ryan C, Lawrence TS, Nikolovska-Coleska Z, Sun Y, Morgan MA.: The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response Nucleic Acids Research 47: 4039-4053, 2019. PMC6486556
  3. Lan H, Tan M, Zhang Q, Yang F, Wang S, Li H, Xiong X, Sun Y: LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity. Proc Natl Acad Sci U S A 116(25): 12311-12320, 2019. PM31152129/PMC6589684
  4. Zhang Q, Karnak D, Tan M, Lawrence TS, Morgan MA, Sun Y: FBXW7 Facilitates Nonhomologous End- Joining via K63-Linked Polyubiquitylation of XRCC4. Molecular Cell 61(3): 419-433, 2016. PM26774286
  5. Zhang Q, Zhang Y, Parsels JD, Lohse I, Lawrence TS, Pasca di Magliano M, Sun Y, Morgan MA: Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia (United States) 18(11): 666-673, 2016. PM27764699
  6. Engelke CG, Parsels LA, Qian Y, Zhang Q, Karnak D, Robertson JR, Tanska DM, Wei D, Davis MA, Parsels JD, Zhao L, Greenson JK, Lawrence TS, Maybaum J, Morgan MA: Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776. Clinical Cancer Research 19(16): 4412-4421, 2013. PM23804422
  7. Zhang Q, Bhojani MS, Ben-Josef E, Spalding AC, Kuick R, Sun Y, Morgan MA: Glycogen Synthase Kinase 3β in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy. J Carcinog Mutagen 4(3): 147, 2013. PM24944842/PMC4059685
  8. Zhang Q, Li Y, Zhang L, Yang N, Meng J, Zuo P, Zhang Y, Chen J, Wang L, Gao X, Zhu D: E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex. Cell Mol Life Sci 70(1): 153- 65, 2013. PM22890573
  9. Huang W*, Smaldino PJ*, Zhang Q*, Miller LD, Cao P, Stadelman K, Wan M, Giri B, Lei M, Nagamine Y, Vaughn JP, Akman SA, Sui G: Yin Yang 1 contains G-quadruplex structures in its promoter and 5’-UTR and its expression is modulated by G4 resolvase 1. Nucleic Acids Research 40(3): 1033-1049, 2012. PM21993297 (co-first)