Dr. Ten Haken has enjoyed a rich and varied career in applications of physics to radiation oncology. These range from early-career measurements of tissue perfusion via photon activation, followed by studies of therapeutic neutron beam dosimetry, on through additional investigations into photon and electron beam dosimetry followed by early innovations in 3-D treatment planning and up to mid-career assessments (together with direction of graduate students and post-docs) of the impact of geometric uncertainties and organ motion on radiation therapy treatments.
These later studies helped alert the community to the need to incorporate patient specific anatomy and setup uncertainties and organ motion into the treatment planning process. Most gratifying to himwas the development of a phase I dose escalation methodology for conformal radiation therapy treatments. Such strategies did not exist prior to the UM team's efforts, and a one-size-fits-all approach to radiation treatments was the standard (i.e., a single tumor dose regardless of tumor size, or more importantly normal tissue dose distributions).
Dr. Ten Haken was the primary innovator of an iso-toxicity dose escalation scheme that led to clinical trials that demonstrated the ability to safely deliver higher doses of radiation to tumors in the liver and lung than had previously been thought possible. Analyses of the results of those dose escalation studies led to the parameterization of normal tissue complication probability (NTCP) models for use in subsequent clinical trials. These published results were among the first of their kind. This led naturally to the desire to use these mathematical models of predicted outcomes directly in optimization of treatment plans. A series of papers demonstrated the strength and flexibility of these approaches. More recently, Dr. Ten Haken has collaborated with others toward the use of physiological imaging and other biomarkers into treatment response assessment of both tumors and normal tissues to irradiation, with the goal of incorporating these techniques into individualized response-based adaptive therapy regimens.
Areas of Interest
- Dr. Ten Haken was a Principal Investigator/Program Director of a long-standing program project grant related to the Optimization of High Dose Conformal Therapy. The overall goal of that program project has been to improve the effectiveness of radiation therapy for cancer patients by individualizing therapy beyond simple anatomy. Specifically, this research seeks to use both anatomical and physiological information acquired during treatment to re-optimize therapy based on the individual patient’s treatment history and response.
- Optimization of radiation therapy treatment planning and delivery.
Honors & Awards
- 2020 William D. Coolidge Gold Medal Award. AAPM
- 2010 Fellow, The American College of Radiology (FACR).
- 2006 Fellow, The American Society for Radiation Oncology (FASTRO)
- 2004 Fellow, The Institute of Physics (FInstP)
- 1997 Fellow, The American Association of Physicists in Medicine (FAAPM)
- PhD, Nuclear Physics, University of Wisconsin – Madison, 1978
- Board Certification: Therapeutic Radiological Physics, 1983-Present
- Board Certification: Radiotherapy Physics, 1990, 2000, 2005, 2010, 2015
P01-CA59827, (PI: TenHaken/Lawrence), 05/15/14-04/30/19, National Cancer Institute, Optimization of High-Dose Conformal Therapy , Role: Co-Program Director/Principal Investigator:
Published Articles or Reviews
Selected from 246 publications
- Ten Haken RK, Martel MK, Kessler ML, Hazuka MB, Lawrence TS, Robertson JM, Turrisi AT, Lichter AS: Use of Veff and iso-NTCP in the implementation of dose escalation protocols. Int J Radiat Oncol Biol Phys. 27:689-695, 1993. dx.doi.org/10.1016/0360-3016(93)90398-F
- Thomas E, Chapet O, Kessler ML, Lawrence TS, Ten Haken RK: The benefit of using biological parameters (EUD and NTCP) in IMRT optimization for the treatment of intrahepatic tumors. Int J Radiat Oncol Biol Phys. 62:571-578, 2005. dx.doi.org/10.1016/j.ijrobp.2005.02.033
- Feng M, Kong F-M, Gross M, Fernando S, Hayman JA, Ten Haken RK: Using fluorodeoxyglucose positron emission tomography to assess tumor volume during radiotherapy for non-small cell lung cancer and its potential impact on adaptive dose escalation and normal tissue sparing. Int J Radiat Oncol Biol Phys. 73:1228-1234, 2009. dx.doi.org/10.1016%2Fj.ijrobp.2008.10.054 PMCID: PMC3381895
- Luo Y, El Naqa I, McShan DL, Ray D, Lohse I, Matuszak MM, Owen D, Jolly S, Lawrence TS, Kong F-M, Ten Haken RK. Unraveling biophysical interactions of radiation pneumonitis in non-small-cell lung cancer via Bayesian network analysis. Radiother Oncol 123:85-92, 2017. DOI: 10.1016/j.radonc.2017.02.004 PMCID: PMC5386796
- El Naqa I, Johansson A, Owen D, Cuneo K, Cao Y, Matuszak MM, Bazzi L, Lawrence TS, Ten Haken RK: Modeling of normal tissue complications using imaging and biomarkers after radiation therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 100:335-343, 2018. DOI: 10.1016/j.ijrobp.2017.10.005 PMCID: PMC5779633