Dr. Shyam Nyati has a long-standing interest in the development and application of molecular imaging to provide new insights into oncological signaling using live cells and mouse models. Signaling activities such as phosphorylation, proteolytic cleavage and ubiquitination impinge on the transformed phenotype. He has developed molecular imaging tools to monitor these regulatory events over the last few years and used them in high-throughput screens, yielding new insights. Currently Dr. Nyati is deciphering the molecular mechanism of radiation sensitivity by MELK kinase and DNA repair pathways.
Areas of Interest
- Basic and translational cancer research
- Signal transduction, mechanisms of therapy resistance and radiation sensitization
- Molecular imaging, cell-based assay development, drug discovery and target validation
Honors & Awards
2019 AAISCR Junior Faculty Award
2019 FASEB-SRC Junior Participant Award
2018 CSCO-AACR Young Investigator Travel Award
2012 Career Development Award (5P50CA093990-11) in Program Grant P50
2010 AACR-Ortho Biotech Scholar-in-Training Award by American Association for Cancer Research (AACR) at the 101st Annual Meeting of AACR in Washington DC
2004 Awarded travel grant by the Institute of Plant Biology, University of Zurich, Switzerland to attend 5th symposium of the International Association for Lichenology (IAL), Tartu, Estonia
2001 Awarded Gold Medal by the University of Mangalore for securing first rank in the Department of Applied Zoology Master’s program
- PhD, University of Zurich, Zurich, Switzerland, 2006
- MSc, University of Mangalore, Mangalore, India, 2000
- BSc, Maharaja's College, University of Rajasthan, Jaipur, India, 1997
Shyam Nyati*, Nauman Chaudhry, Areeb Chatur, Brandon S Gregg, Lauren Kimmel, Dheeraj Khare, Venkatesha Basrur4, Dipankar Ray, and Alnawaz Rehemtulla. A novel reporter for real-time, quantitative imaging of AKT-directed K63-poly-ubiquitination in living cells. Oncotarget (2018).
Corey Speers, Shuang Zhao, Ben Chandler, Meilan Liu, Kari Wilder-Romans, Eric Olsen, Shyam Nyati, Cassandra Ritter, Prasanna Alluri, Vishal Kothari, Daniel Hayes, Theodore Lawrence, Daniel Spratt, Daniel Wahl, Lori Pierce, and Felix Feng. Androgen Receptor (AR) as a mediator and biomarker of radioresistance in triple-negative breast cancer. NPJ Breast Cancer (2017) Aug 18; 3:29.
Shyam Nyati*, Grant Young, Brian D Ross and Alnawaz Rehemtulla. Quantitative and Dynamic Imaging of ATM Kinase Activity by bioluminescent imaging. Methods in Molecular Biology. (ATM Kinase: Methods and Protocols, Ed: Sergei V. Kozlov) Humana Press Inc., (2017) 1599:97-111, (book chapter).
Shyam Nyati*, Grant Young, Brian D Ross and Alnawaz Rehemtulla. Quantitative and Dynamic Imaging of ATM Kinase Activity. Methods in Molecular Biology. (Synthetic Protein Switches: Methods and Protocols, Ed: Viktor Stein) Humana Press Inc., (2017) 1596:131-145, (book chapter).
Shyam Nyati*, Areeb Chator, Katerina Schinske, Brandon S Gregg, Brian Dale Ross, and Alnawaz Rehemtulla. A requirement for ZAK kinase activity in canonical TGF-β signaling. Translational Oncology (2016), 9(6):473-481.
Ray, P, Tan, YS, Somnay, V, Ahsan, A, Naughton, JP, Raghunathan, K, Bridges, A, Nyati, S, Rehemtulla, A, Lawrence, TS, Ray, D, Nyati, MK. Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors. Oncotarget (2016), 7: 68597-68613.