Weihua Zhou

Weihua Zhou, PhD

Research Assistant Professor

4433 Medical Science I

1301 Catherine St

Ann Arbor, MI 48109



Dr. Zhou has been doing basic and translational cancer research for the past 15 years. Her research focuses on mechanistic study of interactions between guanine nucleotide–binding protein (G proteins) signaling pathways and DNA repair in in vitro and orthotopic models.

Areas of Interest

The interactions between G protein signaling pathways and DNA repair


  • PhD: Sun Yat-Sen University, 2012, Guangzhou, PR. China

Published Articles or Reviews

Selected from 20 publications

  • Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, Umemura Y, Walker AK, Kachman M, Sarkaria JN, Xiong J, Morgan MA, Rehemtualla A, Castro MG, Lowenstein P, Chandrasekaran S, Lawrence TS, Lyssiotis CA, Wahl DR. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020 Jul 30;11(1):3811.
  • Zhou W, Xu J, Tan M, Li H, Li H, Wei W, Sun Y. UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F. Mol Cell. 2018 Jun 21;70(6):1008-1024.e6.
  • Zhou H, Zhou W (co-first aurthor), Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang C, Li S, Wang M, Stuckey JA, Sun Y, Wang S. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2018 Feb 13.
  • Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nat Commun. 2017 Jan 16;8:14002.
  • Zhou W, Xu J, Li H, Xu M, Chen Z, Wei W, Pan Z, and Sun Y. Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage. Clin Cancer Res.2017 Feb 15;23(4):1104-1116.