- Zhu J, Huang J, Zhang J, Chen Z, Lin Y, Grigorean G, Li L, Liu S, Singal AG, Parikh ND, Lubman DM. Glycopeptide Biomarkers in Serum Haptoglobin for Hepatocellular Carcinoma Detection in Patients with Non-Alcoholic Steatohepatitis. Journal of Proteome Research. J Proteome Res. 2020 May 29. doi: 10.1021.
- Yin H, Zhu J, Wang M, Yao ZP, Lubman DM. The Quantitative Analysis of Alpha-1-Antitrypsin Glycosylation Isoforms in HCC Patients Using LC-HCD-PRM-MS. Analytical Chemistry, 2020 Jun 16;92(12):8201-8208.
- Peta, Valentina, J. Zhu, D.M. Lubman, et al, “Input of Serum Haptoglobin Fucosylation Profile in the Diagnosis of Hepatocellular Carcinoma in Patients with Non-cirrhotic Liver Disease”, Clinics and Research in Hepatology and Gastroenterology, 2020 Jan 18;S2210-7401(19)30272-4.
- Nyugen, H-Q, D. Lee, Y. Kim, M. Paek, M. Kim, K-S Jang, J. Oh, Y-S Lee, J. Yeon, D. Lubman, J. Kim, "Platelet Factor 4 as a Novel Exosome Marker in MALDI-MS Analysis of Exosomes from Human Serum", Analytical Chemistry, 2019, Oct 15;91(20):13297-13305.
- Liang, J., J. Zhu, M. Wang, A.G. Singal, M. Odewole, S. Kagan, V. Renteria, S. Liu, N.D. Parikh, D.M. Lubman, "Evaluation of AGP Fucosylation as a Marker for Hepatocellular Carcinoma of Three Different Etiologies", Scientific Reports, 2019 Aug 9;9(1):11580.
- Ji X, Huang S, Zhang J, Bruce TF, Tan Z, Wang D, Zhu J, Marcus RK, Lubman, DM, A novel method of high-purity extracellular vesicle enrichment from microliter-scale human serum for proteomic analysis. Electrophoresis. 2021 Feb;42(3):245-256.
- Wu, J., D.M. Lubman, S. Kugathasan, L.A. Denson, J.S.Hyams, et al., "Serum-Based Biomarkers of Intestinal Fibrosis Can Predict Future Stricturing Complication at the Time of Diagnosis in Pediatric Crohn's Disease", Am. J. of Gastroenterology, 2019 May;114(5):777-785304.
- Zhu, J., E. Warner, N.D. Parikh, D.M. Lubman, "Glycoproteomic Markers of Hepatocellular Carcinoma - Mass Spectrometry Based Approaches", Mass Spectrometry Reviews, 2019 May;38(3):265-290.
- Tan, Z., X. Yi, N. Carruthers, P. Stemmer, D. Lubman, "Single Amino Acid Variant Discovery in Small Numbers of Cells", J. of Proteome Research, 2018 Nov 25, 2019 Jan 4;18(1):417-425.
- Zhu, J., Z. Chen, J. Zhang, M. An, J. Wu, Q. Yu, et al. "Differential Quantitative Determination of Site-Specific Intact N-glycopeptides in Serum Haptoglobin between Hepatocellular Carcinoma and Cirrhosis using LC-EthcD-MS/MS", J. of Proteome Research, 2019 Jan 4;18(1):359-371.
- An, M., J. Wu, J. Zhu, D. Lubman, "Comparison of an Optimized Ultracentrifugation Method versus Size-Exclusion Chromatography for Isolation of Exosomes from Human Serum", J.of Proteome Research, 2018 Oct 5; 17(10), 3599-3605.
- David M. Lubman—The University of Michigan—A retrospective in research. Mass Spectrometry Reviews, (2021);1‐9.
Key Publications
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Patents
- Canadian 2401663. Protein Mapping. Filed: 07-Feb-2001.
- European Patent #04701793.4. Method to Form a Protein Microarray System. Filed: 13-Jan-2004.
- U.S. 6,931,325 B2. Three Dimensional Protein Mapping. Filed: 16-Aug-200.
- U.S. 7,069,151 B2. Mapping of Differential Display of Proteins. Filed: 27-Jun-2006.
- US-2008-0096284-A1. Protein Separation and Analysis. Filed: 24-Apr-2008.
- WO2010030641-A2; WO2010030641-A3: US2011236993-A1. Method for Diagnosis Pancreatic Cancer in Subject, Involves Detecting Presence of Cancer Marker Selected From Alpha-1 Beta Glycoprotein, and Amyloid. Patent Assignee: UNIV MICHIGAN. Inventor(s): Li, C., Lubman, D.M., Simeone, D.M.
- WO2007123951-A2; WO2007123951-A3; US2009099036-A1. High Throughput Determination of Glycan Structures by Contacting Lectins With Solid Support Containing Discrete Areas Containing the Sample, and Determining the Glycan Structure of Glycoproteins in the Glycoproteome. Patent Assignee: UNIV MICHIGAN. Inventor(s): Lubman, D.M., Patwa, T.H., Zhao, J.
- US2008153711-A1. Generating Protein Microarrays, Useful for Separation, Identification, and Characterization of Protein Samples Comprises Treating Sample With the First Protein Separation Apparatus to Generate a First Separated Polypeptide Preparation. Patent Assignee: UNIV MICHIGAN. Inventor(s): Lubman, D.M., Chinnaiyan, A.M., Pal, M., et al.
- WO2007112082-A2; WO-2007112082-A3; US2009136960-A1. New System Comprising a Lectin Affinity Chromatography Apparatus and a Liquid Chromatography Apparatus Configured to Receive a Protein Sample Separated by the Lectin Affinity Chromatography Apparatus, Useful in Diagnosing Cancer. Patent Assignee: UNIV MICHIGAN. Inventor(s): Lubman, D.M., Zhao, J., Simeone, D.M.
- WO2004063719-A2; US2004214233-A1; AU2004204502-A1; US2005230315-A1; EP1587840-A2; EP1587840-B1; AU2004204502-B2; DE602004015932-E; US2008280771-A1; WO2004063719-A3. Generating Protein Microarrays Useful in Separatin, Identification and Characterization of Protein Samples, Using Chromatofocusing and HPLC Techniques. Patent Assignee: UNIV MICHIGAN. Inventor(s): Lubman, D.M., Chinnaiyan, A.M., Sreekuymar, A., et al.
- WO2003102539-A; WO2003102539-A2; US2004033591-A1; AU2003237282-A1; AU2003237282-A8; WO2003102539-A3. Apparatus Useful for Automated Sequential Capillary Electrophoresis-Mass Spectroscopy-Mass-Spectroscopy of Protein Fraction Comprises a Software Program. Patent Assignee: UNIV MICHIGAN. Inventor(s): Lubman, D.M., Parus, S., Yoo, C.S.
- WO200288701-A; WO200288701-A1; US2003058239-A1; US2003064527-A1; EP1393061-A1; AU2002308536-A1; US6931325-B2; US2008096284-A1; AU2006203242-A1. Computer System for Displaying Protein Samples From Cell Types, Comprises Computer Software and Display Screen. Patent Assignee: UNIV MICHIGAN. Inventor(s): Wall, D.B., Lubman, D.M., Barder, T., et al.
- WO200158925-A; EP1358202-A; WO200158925-A2; AU200136726-A; US2002098595-A1; EP1358202-A2; JP2004500567-W; MX2002007664-A1; AU2001236726-A8; WO200158925-A3. Capillary Isoelectric Focusing of Proteins and Peptides(s). Patent Assignee; UNIV MICHIGAN. Inventor(s): Lubman, D.M., Barder, T.J., Wall, D.B., et al.
- WO200159460-A; EP1256001-A; WO200159460-A2; AU200134880-A; US2002039747-A1; EP1256001-A2; JP2003534533-W; US2004010126-A1; MX2002007665-A1; US7069151-B2; CA2400460-C; WO200159460-A3. Method for Mass Protein Mapping Comprises Separating Protein Samples Into Fractions, and Analyzing Using Mass Spectroscopy. Patent Assignee: UNIV MICHIGAN. Inventor(s): Lubman, D.M., Chong, B.E., Parus, S.J., et al.
- EP1385869-A; WO200158926-A2; AU200134893-A; EP1385869-A2; MX2002007771-A1; AU2001234893-A8; CA2401663-C; WO200158926-A3. Separating Cellular Proteins Using a Multidimensional Separation Apparatus. Patent Assignee: UNIV MICHIGAN. Inventor(s): Lubman, D.M., Barder, T.J., Wall, D.B., et al.
