- Phenformin inhibits myeloid-derived suppressor cells and enhances the anti-tumor activity of PD-1 blockade in melanoma. Kim SH, Li M, Trousil S, Zhang Y, Pasca di Magliano M, Swanson KD, Zheng B. J Invest Dermatol. 2017
- Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Zhang Q, Zhang Y, Parsels JD, Lohse I, Lawrence TS, Pasca di Magliano M, Sun Y, Morgan MA. Neoplasia. 2016 Nov;18(11):666-673.
- Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Zhang Y, Velez-Delgado A, Mathew E, Li D, Mendez FM, Flannagan K, Rhim AD, Simeone DM, Beatty GL, Pasca di Magliano M. Gut. 2017 Jan;66(1):124-136.
- Early pancreatic islet fate and maturation is controlled through RBP-Jκ. Cras-Méneur C, Conlon M, Zhang Y, Pasca Di Magliano M, Bernal-Mizrachi E. Sci Rep. 2016 May 31;6:26874.
- Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of Macrophages. Mathew M, Brannon AL, Del Vecchio ACD, Garcia PE, Penny MK, Kane KT, Vinta A, Buchanovich RJ, Pasca di Magliano M. Neoplasia 2016 Mar; 18(3):142-151.
- GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer. Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, Schradle KA, Urs S, Pasca Di Magliano M, Welling TH, Palmbos PL, Abel EV, Sahai V, Nagrath S, Wang L, Simeone DM. Cancer Discov. 2016 Aug;6(8):886-99.
- Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation. Yang S, Imamura Y, Jenkins RW, Cañadas I, Kitajima S, Aref A, Brannon A, Oki E, Castoreno A, Zhu Z, Thai T, Reibel J, Qian Z, Ogino S, Wong KK, Baba H, Kimmelman AC, Pasca Di Magliano M, Barbie DA. Cancer Immunol Res. 2016 Jun;4(6):520-30.
- Change isn't always better. Schofield H, Pasca di Magliano M. Elife. 2015 Aug 14;4.
- Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism. Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M. Carcinogenesis. 2015;36(7):730-8.
- ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis. Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM. Genes Dev. 2015; 29(2):171-83.
Key Publications
Learn More
Marina Pasca di Magliano, PhD discusses the recent developments in progress against pancreatic cancer.