Gastric Fuel Sensing

• Xu G, Li Y, An W, Li  S, Guan Y, Wang N, Tang C, Wang X, Zhu Y, Li X, Mulholland MW, Zhang W. Gastric mTOR signaling regulates ghrelin production and food intake. Endocrinology 2009;150:3637-44. PMC2717890
• Li Z, Mulholland MW, Zhang W: Regulation of gastric nesfatin-1/NUCB2. Curr Pharm Des 2013;19(39):6981-5. PMID: 23537086
• Li Z, Xu G, Li Y, Zhao J, Mulholland MW, Zhang W. mTOR-dependent modulation of gastric nesfatin-1. Cell Physiol Biochem 2012;29:493-500. PMC3711577
• Ma L, Tang H, Yin Y, Yu R, Zhao J, Li Y, Mulholland M, Zhang W. HDAC5-mTORC1 interaction in differential regulation of ghrelin and nucleobindin2 (NUCB2)/nesfatin-1. Mol Endocrinol 2015;29:1571-80. PMID: 23998356. 

Hepatic Steatosis

• Xu G, Wang Z, Li Y, Li Z, Tang H, Zhao J, Xiang X, Ding L, MaL, Yuan F, Fei J, Wang W, Wang N, Guan Y, Tang C, Mulholland MW, Zhang W. Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice.  Diabetologia 2012;55:1813-1823.PMID:22391948.
• Qin Y, LiZ, Wang Z, Li Y, Zhao J, Mulholland MW, Zhang W. Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion. Liver Int 2014;34:567-75. PMID: 23998356.        
• Li Z, Xu G, Qin Y, Zhang C, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland MW, Zhang W. Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARg signaling pathway. Proc Natl Acad Sci USA 2014;111:13163-8. PMC4246976.  
• Hepatology. 2019 Feb;69(2):860-875. doi: 10.1002/hep.30229. Epub 2018 Dec 31.

LGR4 – R-spondin

• Li Y, Chai B, Zhang W, Wu X, Zhang C, Fritz D, Xia Z, Patterson C, Mulholland MW. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation. BMC Neurosc 2011;12:95. PMC3192677.
• Chai B, Li J, Fritze D, Zhang W, Xia Z, Mulholland MW. A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signaling. J Neuroendocrinology 2013;25(3), 292-301. PMID: 22935015.
• Li JY, Chai B, Zhang W, Fritze DM, Zhang C, Mulholland, MW. LGR4 and its ligands, R-spondin 1 and 3, regulate food intake in the hypothalamus of male rats. Endocrinology 2014;155(2):429-440. PMC3891940.
• Li Z, Zhang W and Mulholland M. LGR4 and its role in intestinal protection and energy metabolism. Frontiers in Endocrinology 2015;6:131. PMC4548225.

Additional Publications