Dr. Darleen Sandoval is an Associate Professor of Surgery at the University of Michigan School of Medicine. Dr. Sandoval received her Ph.D. in Exercise Science at Arizona State University and received a Postdoctoral Fellowship at Vanderbilt University in the Division of Endocrinology. Dr. Sandoval then moved to University of Cincinnati and obtained a NIH-Career Development Award. While her postdoctoral work highlighted the importance of the ability of the CNS to sense and initiate responses to decreases in nutrient availability, her career development award focused the ability of the CNS to regulate postprandial glucose metabolism in response to neuroendocrine feedback. Dr. Sandoval's current work utilizes basic research strategies to focus on two general themes of research. The first goal is to gain understanding on the role of a gastrointestinal peptide, GLP-1, in the gut-brain axis to regulate energy and glucose homeostasis. The second is to gain understanding on the adaptations of the gut-brain axis with bariatric surgery and how this leads to the profound weight-loss and improvements in glucose and lipid homeostasis seen with these surgeries. Both research themes use a combination of molecular and physiological techniques with the goal of generating better therapeutic options for obesity and type 2 diabetes.