September 23, 2021

Board of Regents approves appointment of two Medical School faculty to leadership positions

Karl J. Jepsen, Ph.D., is associate dean for research and Daniel E. Michele, Ph.D., is interim chair of the Department of Molecular & Integrative Physiology, both effective Sept. 1

Karl J. Jepsen, Ph.D., and Daniel E. Michele, Ph.D.

The Board of Regents today (Sept. 23) approved the appointment of Karl J. Jepsen, Ph.D., as associate dean for research and Daniel E. Michele, Ph.D., as interim chair of the Department of Molecular & Integrative Physiology, both effective Sept. 1, 2021.

Karl J. Jepsen, Ph.D. 

Jepsen, left, will be involved in operations of the Medical School Office of Research, working closely with basic and translational research faculty and staff.

He is a professor of orthopaedic surgery and biomedical engineering in the Medical School and College of Engineering. He also is director of the Michigan Integrative Musculoskeletal Health Core Center and chair of the Laboratory and Research Safety Committee.

He earned B.S. and M.S. degrees in mechanical engineering from Wayne State University, and his M.S. and Ph.D. in bioengineering from the University of Michigan. He conducted his postdoctoral training at Case Western Reserve University, where he then served as an assistant professor in the Department of Orthopaedics. In 1999, he accepted a position in the Department of Orthopaedics at the Mount Sinai School of Medicine in New York City. He returned to Michigan in 2011 as a professor of orthopaedic surgery. He was jointly appointed as a professor in the Department of Biomedical Engineering in 2014.

Jepsen’s research program focuses on understanding how complex physiological systems such as the skeletal system establish function during growth and maintain function during aging. Having a better understanding of how complex systems work is expected to benefit efforts to reduce fracture risk by identifying the genetic and environmental factors that impair (or promote) specific components of the functional adaptation process that compromise (or improve) musculoskeletal health.

He collaborates with faculty across campus and institutions with the collective goal of giving a voice to a silent disease by identifying early indicators of skeletal fracture risk that will enable more precise and effective ways to treat individuals earlier in life.

Daniel E. Michele, Ph.D.

Michele, right, will assume leadership of his department while a national search commences.

He obtained his undergraduate degree from Calvin College. He completed his Ph.D. at the University of Michigan in 2000 and was a postdoctoral fellow at the University of Iowa from 2000-04. He joined the faculty at the University of Michigan in 2004 as an assistant professor. He rose through the ranks to associate professor in 2011 and to professor in 2017. He also holds an appointment as professor of internal medicine.

His research laboratory is focused on the mechanisms of muscular dystrophy associated with mutations in the transmembrane dystrophin-glycoprotein complex.

In addition to his scholarly research, he has been extensively involved in departmental and university-wide committees, including education, advocacy and outreach, and administrative service. He previously served as director of the Molecular & Integrative Physiology Graduate Program and is founding director of the Frankel Cardiovascular Center Summer Undergraduate Fellowship Program. He also is director of the Cardiovascular Research and Entrepreneurship T32 training program and director of the Physiology Phenotyping Core, which is supported by Molecular & Integrative Physiology, the Frankel Cardiovascular Center, and the National Institutes of Health-funded Michigan Musculoskeletal Health Center.